ID | 52813 |
FullText URL | |
Author |
Sonoi, Norihiro
Ichimura, Koichi
Aoyama, Kazutoshi
Maeda, Yoshinobu
Kaken ID
researchmap
Logan, Richard
Raber-Durlacher, Judith
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Abstract | Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed both before and after chemotherapy. The patient was a 39-year-old Japanese woman with AML-M4 showing gingival enlargement. Histological and immunohistochemical features of gingiva and bacterial counts in the periodontal pockets were examined before and after chemotherapy. The results were as follows: (1) infiltration of myelomonocytic blasts in enlarged gingiva; (2) resolution of gingival enlargement with complete remission of AML by anticancer chemotherapy; and (3) the numbers of bacteria in the periodontal pockets were not high and were not altered before or after chemotherapy. In patients with AML-M4, remarkable mucosal enlargement is not generally observed in the body except in the gingiva. We hypothesized that antigens derived from periodontal bacteria, even if they are not present in large numbers, could act as chemoattractants for myelomonocytic leukemic cells.
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Keywords | Gingival enlargement
Acute myelomonocytic leukemia
Pathogenesis
Histology
Immunohistochemistry
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Note | The final publication is available at link.springer.com
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Published Date | 2012-07
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Publication Title |
Odontology
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Volume | volume100
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Issue | issue2
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Start Page | 254
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End Page | 257
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ISSN | 1618-1247
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Content Type |
Journal Article
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language |
English
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Copyright Holders | © The Society of The Nippon Dental University 2011
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File Version | author
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Refereed |
True
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DOI | |
Web of Science KeyUT |