| ID | 58261 |
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| Author |
Hirano, Yutaka
Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sugimoto, Seiichiro
Department of General Thoracic Surgery, Okayama University Hospital
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Yamamoto, Sumiharu
Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okada, Masanori
Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Otani, Shinji
Department of Organ Transplant Center, Okayama University Hospital
Ohara, Toshiaki
Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Yamane, Masaomi
Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Matsukawa, Akihiro
Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Toyooka, Shinichi
Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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| Abstract | Objective: In lung transplantation (LTx) from donation after cardiac death (DCD), the donor lungs are inevitably exposed to warm ischemic time (WIT) between the cardiac arrest and the initiation of cold preservation. We conducted this study to examine the effect of prolonged WIT on lung allograft rejection in a murine model of LTx from DCD.
Methods: Allogeneic BALB/c → B6 LTx from DCD was performed with a WIT of 15 min (WIT15 group, n = 5) or 60 min (WIT60 group, n = 5). Recipients were immunosuppressed by perioperative costimulatory blockade. The lung allografts were analyzed by histology and flow cytometry on day 7 after the LTx. Results: Histologically, the rejection grade in the WIT60 group was significantly higher than that in the WIT15 group (3.4 ± 0.4 vs. 2.2 ± 0.2, P = 0.0278). Moreover, the intragraft CD8+ to CD4+ T cell ratio in the WIT60 group was significantly higher than that in the WIT15 group (2.3 ± 0.12 vs. 1.2 ± 0.11, P < 0.0001). Conclusions: Prolonged WIT could exacerbate the severity of lung allograft rejection after LTx from DCD. Minimization of the WIT could improve the outcomes after LTx from DCD. |
| Keywords | Brain dead donor
Donation after cardiac death
Lung transplantation
Organ preservation
Rejection
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| Note | This is a post-peer-review, pre-copyedit version of an article published in General Thoracic and Cardiovascular Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-019-01181-9.
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| Published Date | 2019-07-31
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| Publication Title |
General Thoracic and Cardiovascular Surgery
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| Volume | volume68
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| Issue | issue1
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| Publisher | Springer
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| Start Page | 57
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| End Page | 62
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| ISSN | 1863-6705
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| NCID | AA12201344
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| File Version | author
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| PubMed ID | |
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| Related Url | isVersionOf https://doi.org/10.1007/s11748-019-01181-9
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| License | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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| Citation | Hirano, Y., Sugimoto, S., Yamamoto, S. et al. Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse. Gen Thorac Cardiovasc Surg 68, 57–62 (2020). https://doi.org/10.1007/s11748-019-01181-9
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| Funder Name |
Japan Society for the Promotion of Science
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| 助成番号 | 24791461
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