ID | 31826 |
JaLCDOI | |
FullText URL | |
Author |
Fujikawa, Tatsuya
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Abstract | Serum des-gamma-carboxy prothrombin (DCP) is commonly used to detect hepatocellular carcinoma (HCC). This review focuses on the clinical features of DCP-positive HCC and the molecular function of DCP in HCC. DCP-positive HCC demonstrates more aggressive clinicopathological features than DCP-negative HCC. Analysis of the biological effects of DCP revealed that DCP acts as a growth factor in both an autocrine and paracrine manner. DCP stimulates HCC cell proliferation through the Met-Janus kinase 1-signal transducer and activator of transcription 3 signaling pathway, whereas for vascular endothelial cells, it stimulates cell proliferation and migration through the kinase insert domain receptor-phospholipase C-gamma-mitogen-activated protein kinase signaling pathway. |
Keywords | des-gamma-carboxy prothrombin
hepatocellular carcinoma
signaling pathway
cell proliferation
angiogenesis
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Amo Type | Review
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Publication Title |
Acta Medica Okayama
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Published Date | 2009-12
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Volume | volume63
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Issue | issue6
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Publisher | Okayama University Medical School
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Start Page | 299
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End Page | 304
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |