ID | 63807 |
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Author |
Kashimoto, Rena
Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
Furukawa, Saya
Department of Biological Sciences, Faculty of Science, Okayama University
Yamamoto, Sakiya
Department of Biological Sciences, Faculty of Science, Okayama University
Kamei, Yasuhiro
National Institute for Basic Biology (NIBB), National Institutes for Natural Sciences
Sakamoto, Joe
National Institute for Basic Biology (NIBB), National Institutes for Natural Sciences
Nonaka, Shigenori
National Institute for Basic Biology (NIBB), National Institutes for Natural Sciences
Watanabe, Tomonobu M.
Laboratory for Comprehensive Bioimaging, RIKEN Center for Biosystems Dynamics Research (BDR)
Sakamoto, Tatsuya
Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
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Sakamoto, Hirotaka
Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
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Satoh, Akira
Research Core for Interdisciplinary Sciences (RCIS), Okayama University
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Abstract | The morphology of collagen-producing cells and the structure of produced collagen in the dermis have not been well-described. This lack of insights has been a serious obstacle in the evaluation of skin regeneration. We succeeded in visualizing collagen-producing cells and produced collagen using the axolotl skin, which is highly transparent. The visualized dermal collagen had a lattice-like structure. The collagen-producing fibroblasts consistently possessed the lattice-patterned filopodia along with the lattice-patterned collagen network. The dynamics of this lattice-like structure were also verified in the skin regeneration process of axolotls, and it was found that the correct lattice-like structure was not reorganized after simple skin wounding but was reorganized in the presence of nerves. These findings are not only fundamental insights in dermatology but also valuable insights into the mechanism of skin regeneration.
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Published Date | 2022-07-15
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Publication Title |
iScience
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Volume | volume25
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Issue | issue7
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Publisher | CELL PRESS
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Start Page | 104524
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ISSN | 2589-0042
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2022 The Author(s).
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.1016/j.isci.2022.104524
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License | http://creativecommons.org/licenses/by-nc-nd/4.0/
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