Author | Hara, Emilio Satoshi| Ono, Mitsuaki| Eguchi, Takanori| Kubota, Satoshi| Hai, Thanh Pham| Sonoyama, Wataru| Tajima, Shoji| Takigawa, Masaharu| Stuart K., Calderwood| Kuboki, Takuo| |
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Published Date | 2013-12-27 |
Publication Title | PLOS ONE |
Volume | volume8 |
Issue | issue12 |
Content Type | Journal Article |
Author | Maeda-Uematsu, Aya| Kubota, Satoshi| Kawaki, Harumi| Kawata, Kazumi| Miyake, Yoshiaki| Hattori, Takako| Nishida, Takashi| Moritani, Norifumi| Lyons, Karen M.| Iida, Seiji| Takigawa, Masaharu| |
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Published Date | 2014-05 |
Publication Title | Journal of Cellular Biochemistry |
Volume | volume115 |
Issue | issue5 |
Content Type | Journal Article |
Author | Kikuchi, Takeshi| Kubota, Satoshi| Asaumi, Koji| Kawaki, Harumi| Nishida, Takashi| Kawata, Kazumi| Mitani, Shigeru| Tabata, Yasuhiko| Ozaki, Toshifumi| Takigawa, Masaharu| |
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Published Date | 2008-06 |
Publication Title | Tissue Engineering Part A |
Volume | volume14 |
Issue | issue6 |
Content Type | Journal Article |
Author | Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu| |
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Published Date | 2011-06-03 |
Publication Title | Biochemical and Biophysical Research Communications |
Volume | volume409 |
Issue | issue2 |
Content Type | Journal Article |
FullText URL | Fulltext.pdf fig.pdf table.pdf |
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Author | Matsumoto, Yohsuke| Motoki, Takahiro| Kubota, Satoshi| Takigawa, Masaharu| Tsubouchi, Hirohito| Gohda, Eiichi| |
Keywords | hepatocyte growth factor valproic acid histone deacetylase inhibitor butyric acid trichostatin A induction tumor invasion dermal fibroblast |
Note | Published with permission from the copyright holder. This is a author's copy,as published in Biochemical and Biophysical Research Communications, 2008 Vol.366 Issue.1 pp.110-116 | |
Published Date | 2008-02-01 |
Publication Title | Biochemical and Biophysical Research Communications |
Volume | volume366 |
Issue | issue1 |
Publisher | Academic Press |
Start Page | 110 |
End Page | 116 |
ISSN | 0006-291X |
NCID | AA00564395 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 18053801 |
DOI | 10.1016/j.bbrc.2007.11.089 |
Web of Science KeyUT | 000252392400018 |
Author | Moritani, Norifumi H| Kubota, Satoshi| Sugahara, Toshio| Takigawa, Masaharu| |
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Published Date | 2005-04-15 |
Publication Title | Cell Communication and Signaling |
Volume | volume3 |
Issue | issue1 |
Content Type | Journal Article |
Author | Asano, Masahiro| Kubota, Satoshi| Nakanishi, Tohru| Nishida, Takashi| Yamaai, Tomoichiro| Yosimichi, Gen| Ohyama, Kazumi| Sugimoto, Tomosada| Murayama, Yoji| Takigawa, Masaharu| |
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Published Date | 2005-10-05 |
Publication Title | Cell Communication and Signaling |
Volume | volume3 |
Issue | issue1 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/30956 |
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FullText URL | fulltext.pdf |
Author | Doi, Hideyuki| Nishida, Keiichiro| Yorimitsu, Masanori| Komiyama, Takamitsu| Kadota, Yasutaka| Tetsunaga, Tomonori| Yoshida, Aki| Kubota, Satoshi| Takigawa, Masaharu| Ozaki, Toshifumi| |
Abstract | Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes. |
Keywords | IL-4 MMP cathepsin B mechanical stress aggrecanase |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2008-04 |
Volume | volume62 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 119 |
End Page | 126 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 18464888 |
Web of Science KeyUT | 000255297600008 |