Author | Obika, Masanari| Ogawa, Hiroko| Takahashi, Katsuyuki| Li, Jiayi| Hatipoglu, Omer Faruk| Cilek, Mehmet Zeynel| Miyoshi, Toru| Inagaki, Junko| Ohtsuki, Takashi| Kusachi, Shozo| Ninomiya, Yoshifumi| Hirohata, Satoshi| |
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Published Date | 2012-10 |
Publication Title | Cancer Science |
Volume | volume103 |
Issue | issue10 |
Content Type | Journal Article |
Author | Matsuura, Hiroko| Murakami, Takashi| Hina, Kazuyoshi| Yamamoto, Keizo| Kawamura, Hiroshi| Sogo, Taiji| Shinohata, Ryoko| Usui, Shinichi| Ninomiya, Yoshifumi| Kusachi, Shozo| |
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Published Date | 2008-02 |
Publication Title | Clinical Biochemistry |
Volume | volume41 |
Issue | issue3 |
Content Type | Journal Article |
Author | Toeda, Kenichi| Nakamura, Keigo| Hirohata, Satoshi| Hatipoglu, Omer F.| Demircan, Kadir| Yamawaki, Hitoshi| Ogawa, Hiroko| Kusachi, Shozo| Shiratori, Yasushi| Ninomiya, Yoshifumi| |
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Published Date | 2005-12 |
Publication Title | Molecular and Cellular Biochemistry |
Volume | volume280 |
Issue | issue1-2 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/32213 |
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FullText URL | fulltext.pdf |
Author | Cheng, Xiao-shu| Kusachi, Shozo| Urabe, Norio| Nogami, Kunio| Takemoto, Masao| Morishita, Naoya| Haraoka, Shoichi| Tsuji, Takao| |
Abstract | The association between the extent of left ventricular (LV) hypertrophy and severity of ventricular or atrial arrhythmias are examined. Two-dimensional echocardiography and 24-h Holter electrocardiography monitoring were performed in 60 patients with hypertrophic cardiomyopathy (HCM). According to the distribution of the LV hypertrophy, the patients were divided into three groups: 1. Apical hypertrophy (APH), 2. Septal hypertrophy, and 3. Extensive hypertrophy. Ventricular arrhythmias were found in 82% of the patients and supraventricular arrhythmias were detected in 70% of the patients. Lown grade III and IV arrhythmias occurred significantly more frequently in patients with extensive than with septal hypertrophy. Lown grade III to IV arrhythmias did not occur in patients with APH. Present results show a significant association between the extent of LV hypertrophy and the severity of ventricular arrhythmias in HCM. </P> |
Keywords | hypertrophic cardiomyopathy arrhythmia echocardiography Holter ECG |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1991-06 |
Volume | volume45 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 155 |
End Page | 159 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 1832510 |
Web of Science KeyUT | A1991FV15000005 |
JaLCDOI | 10.18926/AMO/31831 |
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FullText URL | fulltext.pdf |
Author | Hatipoglu, Omer Faruk| Hirohata, Satoshi| Yaykasli, Kursat Oguz| Cilek, Mehmet Zeynel| Demircan, Kadir| Shinohata, Ryoko| Yonezawa, Tomoko| Oohashi, Toshitaka| Kusachi, Shozo| Ninomiya, Yoshifumi| |
Abstract | ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an inflammatory-induced gene. We have previously reported that ADAMTS1 was strongly but transiently expressed in the infarcted heart. In this study, we investigated whether a 3'-untranslated region (UTR) affects the mRNA stability of this gene. When stimulated with tissue necrosis factor (TNF)-alpha, the expression level of ADAMTS1 mRNA rapidly increased, but the induction of ADAMTS1 mRNA peaked at 6h after stimulation, after which the expression levels of ADAMTS1 mRNA decreased. The 3'-UTR ADAMTS1 mRNA contains multiple adenine and uridine-rich elements, suggesting that the 3'-UTR may regulate gene stability. The addition of actinomycin D, an RNA synthesis inhibitor, demonstrated the decay of induced ADAMTS1 mRNA by TNF-alpha. Furthermore, a region containing multiple AUUUA motifs within the ADAMTS1 3'-UTR destabilized transfected Enhanced Green Fluorescence Protein (EGFP) mRNA expression. These results demonstrated that the ADAMTS1 3'-UTR may regulate the expression of ADAMTS1 mRNA. |
Keywords | ADAMTS1 gene regulation metalloproteinase |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2009-04 |
Volume | volume63 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 79 |
End Page | 85 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19404339 |
Web of Science KeyUT | 000265457600002 |
JaLCDOI | 10.18926/AMO/30893 |
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FullText URL | fulltext.pdf |
Author | Kusachi, Shozo| Iwasaki, Kohichirou| Nishiyama, Osamu| Ueda, Minoru| Kita, Toshimasa| Hata, Takato| Taniguchi, Gyou| Watanabe, Hirofumi| Hina, Kazuyoshi| Saito, Daiji| Tsuji, Takao| Haraoka, Shoichi| |
Abstract | We studied the factors which may induce acute high grade restenosis in emergency percutaneous transluminal coronary angioplasty (PTCA). PTCA was attempted in 50 patients with acute myocardial infarction, and the balloon catheter passed successfully across the occlusion site in 47 (94%) of the patients. These 47 patients were analyzed. "Acute restenosis" was defined as a lesion which was revascularized to less than 50% luminal reduction narrowed again to more than 75% luminal reduction 5 min after the balloon inflation. Univariate and multivariate analyses were used for determining factors which significantly influenced acute restenosis. The incidence of at least one restenosis episode was 45%. Multiple regression analysis selected 5 factors associated significantly with an increased rate of acute restenosis: 1) angiographic evidence of dissection, 2) lesion in the right coronary artery (RCA), 3) lack of or insufficient administration of thrombolytic agent preceding PTCA, 4) curved lesion and 5) relatively small balloon/artery diameter ratio. Acute restenosis correlated significantly with late reocclusion. This study indicates that it is important to administer a thrombolytic agent prior to emergency PTCA, and to use an adequately sized balloon to the artery when the acute restenosis occurs by using relatively smaller sized balloon. The present data also demonstrated that patients with RCA and a curved lesion have a relatively high risk of acute restenosis. This study indicates how patients with relatively high risk of acute restenosis may be identified. |
Keywords | emergency coronary angioplasty restenosis acute myocardial infarction multivariate analysis |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1989-02 |
Volume | volume43 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 55 |
End Page | 63 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 2524153 |
Web of Science KeyUT | A1989T938500007 |
JaLCDOI | 10.18926/AMO/30538 |
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FullText URL | fulltext.pdf |
Author | Saito, Daiji| Kusachi, Shozo| Nishiyama, Osamu| Yasuhara, koichiro| Yoshida, Hidenori| Haraoka, Shoichi| |
Abstract | The effects of changes in distal resistance on stenotic resistance were studied in vitro. Physiological saline was passed through the left carotid artery obtained from the dog, flexible rubber tubing, or through solid polyethylene tubing with a constant perfusion pressure or with a constant flow rate. Various stenotic resistances were established using a screw type constrictor and the distal resistance was varied by allowing physiological saline to pass through either a 23 gauge hypodermic needle (high peripheral resistance) or 23 and 20 gauge needles (low peripheral resistance ). For arteries with anatomically fixed stenosis, the calculated resistance was increased in association with reduction of the distal resistance. The stenotic resistance in the flexible rubber tubing changed in the same manner as that of the carotid artery, while the solid polyethylene tubing showed no significant stenotic resistance changes due to altering the distal resistance. These findings suggest that the stenotic resistance change of the artery correlates with the elasticity of the vessel wall and also indicate that resistance values were of little usefulness for evaluating the effects of vasodilating stimuli on the vessel segment with a significant stenosis. |
Keywords | stenotic resistance constant perfusion pressure constant flow rate. |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1980-04 |
Volume | volume34 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 109 |
End Page | 115 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 6450512 |
Web of Science KeyUT | A1980JY15600004 |
Author | Haraoka, Shoichi| Saito, Daiji| Ueda, Minoru| Ogino, Yasuhiro| Kusuhara, Shunichi| Yoshida, Hidenori| Kawasaki, Tomoko| Miyasaka, Minoru| Yoshioka, Nobuhiko| Ikenaga, Toyotake| Kusachi, Shozo| Sogo, Yasushi| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Hisamatsu, Mitsuo| Nukada, Kaname| Imada, Kakuro| Hirata, Takako| Kasu, Yoshiko| |
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Published Date | 1978-12-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume90 |
Issue | issue11-12 |
Content Type | Journal Article |
Author | Haraoka, Shoichi| Saito, Daiji| Ueda, Minoru| Ogino, Yasuhiro| Kusuhara, Shunichi| Yoshida, Hidenori| Kawasaki, Tomoko| Miyasaka, Minoru| Yoshioka, Nobuhiko| Ikenaga, Toyotake| Kusachi, Shozo| Sogo, Yasushi| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Hisamatsu, Mitsuo| Nukada, Kaname| Imada, Kakuro| Hirata, Takako| Kasu, Yoshiko| |
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Published Date | 1978-12-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume90 |
Issue | issue11-12 |
Content Type | Journal Article |
Author | Haraoka, Shoichi| Saito, Daiji| Ueda, Minoru| Ogino, Yasuhiro| Kusuhara, Shunichi| Yoshida, Hidenori| Kawasaki, Tomoko| Miyasaka, Minoru| Yoshioka, Nobuhiko| Ikenaga, Toyotake| Kusachi, Showzo| Sogo, Taiji| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Hisamatsu, Mitsuo| Ioriya, Kazuo| Nukada, Kaname| Imada, Kakuro| Hirata, Takako| Kasu, Yoshiko| |
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Published Date | 1979-12-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume91 |
Issue | issue11-12 |
Content Type | Journal Article |
Author | Yoshida, Hidenori| Kusuhara, Shunichi| Yoshioka, Nobuhiko| Kusachi, Showzo| Sogo, Taiji| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Ueda, Minoru| Saito, Daiji| Mae, Ritsuo| Shimada, Yoshihiro| Matsuura, Hidemitsu| Omori, Hiroyuki| Kimoto, Katsuhiko| Shigei, Hiroshi| Haraoka, Shoichi| |
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Published Date | 1979-04-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume91 |
Issue | issue3-4 |
Content Type | Journal Article |
Author | Yoshida, Hidenori| Uesugi, Seiichiro| Yuasa, Shiro| Kusachi, Showzo| Sogo, Taiji| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Kouichiro| Ueda, Minoru| Saito, Daiji| Mae, Ritsuo| Shimada, Yoshihiro| Haraoka, Shoichi| |
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Published Date | 1979-04-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume91 |
Issue | issue3-4 |
Content Type | Journal Article |
Author | Haraoka, Shoichi| Saito, Daiji| Ueda, Minoru| Ogino, Yasuhiro| Kusuhara, Shunichi| Yoshida, Hidenori| Kawasaki, Tomoko| Misayaka, Minoru| Yoshioka, Nobuhiko| Ikenaga, Toyotake| Kusachi, Showzo| Sogo, Taiji| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Hisamatsu, Mitsuo| Nukada, Kaname| Imada, Kakuro| Hirata, Takako| Kasu, Yoshiko| |
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Published Date | 1979-02-28 |
Publication Title | 岡山医学会雑誌 |
Volume | volume91 |
Issue | issue1-2 |
Content Type | Journal Article |
Author | Haraoka, Shoichi| Yoshida, Hidenori| Saito, Daiji| Ueda, Minoru| Kusachi, Shozo| Nishiyama, Osamu| Yasuhara, Koichiro| Yamada, Nobuyuki| Ihoriya, Kazuo| Fujii, Akinobu| Kimura, Shoji| Takeda, Ko| Hyodo, Tatsuo| Uchida, Toshiaki| Nishihara, Masanobu| 吉田 暎| 日下 幸恵| |
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Published Date | 1981-06-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume93 |
Issue | issue5-6 |
Content Type | Journal Article |
Author | Kusachi, Shozo| |
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Published Date | 1983-06-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume95 |
Issue | issue5-6 |
Content Type | Journal Article |
Author | Nakagawa, Hiroshi| Kusachi, Shozo| Oka, Takefumi| Urabe, Norio| Nogami, Kunio| Takemoto, Masao| Morishita, Naoya| Inoue, Kimihito| Tsuji, Takao| Tomita, Susumu| |
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Published Date | 1992 |
Publication Title | 岡山医学会雑誌 |
Volume | volume104 |
Issue | issue5-6 |
Content Type | Journal Article |
Author | 草地 省藏| |
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Published Date | 1984-03-31 |
Publication Title | |
Content Type | Thesis or Dissertation |