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Author
Nakada, Tetsuya Graduate School of Health Sciences, Okayama University
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University ORCID Kaken ID publons researchmap
Nomura, Takaharu Central Research Institute of Electric Power Industry
Shuto, Hina Graduate School of Health Sciences, Okayama University
Yano, Junki Graduate School of Health Sciences, Okayama University
Naoe, Shota Graduate School of Health Sciences, Okayama University
Hanamoto, Katsumi Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
Abstract
The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower in the 3.0 mGy/h irradiated mice than in sham irradiated mice. The FST significantly decreased the catalase (CAT) activity and total glutathione (t-GSH) content in the brain and kidney, respectively. The superoxide dismutase (SOD) activity and t-GSH content in the liver of the 3.0 mGy/h irradiated mice were significantly lower than those of the non-FST-treated mice. The CAT activity in the lungs of mice exposed to 3.0 mGy/h γ-irradiation was higher than that of non-FST treated mice and mice treated with FST. However, no significant differences were observed in the levels of these antioxidant markers between the sham and irradiated groups except for the CAT activity in lungs. These findings suggest that the effects of low-dose-rate and low-dose γ-irradiation on FST are highly organ-dependent.
Keywords
low-dose-rate γ-irradiation
forced swim test
antioxidant
oxidative stress
Amo Type
Original Article
Publication Title
Acta Medica Okayama
Published Date
2021-04
Volume
volume75
Issue
issue2
Publisher
Okayama University Medical School
Start Page
169
End Page
175
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
Copyright Holders
CopyrightⒸ 2021 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
NAID