ID | 61896 |
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Author |
Nakada, Tetsuya
Graduate School of Health Sciences, Okayama University
Kataoka, Takahiro
Graduate School of Health Sciences, Okayama University
ORCID
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Nomura, Takaharu
Central Research Institute of Electric Power Industry
Shuto, Hina
Graduate School of Health Sciences, Okayama University
Yano, Junki
Graduate School of Health Sciences, Okayama University
Naoe, Shota
Graduate School of Health Sciences, Okayama University
Hanamoto, Katsumi
Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori
Graduate School of Health Sciences, Okayama University
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Abstract | The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower in the 3.0 mGy/h irradiated mice than in sham irradiated mice. The FST significantly decreased the catalase (CAT) activity and total glutathione (t-GSH) content in the brain and kidney, respectively. The superoxide dismutase (SOD) activity and t-GSH content in the liver of the 3.0 mGy/h irradiated mice were significantly lower than those of the non-FST-treated mice. The CAT activity in the lungs of mice exposed to 3.0 mGy/h γ-irradiation was higher than that of non-FST treated mice and mice treated with FST. However, no significant differences were observed in the levels of these antioxidant markers between the sham and irradiated groups except for the CAT activity in lungs. These findings suggest that the effects of low-dose-rate and low-dose γ-irradiation on FST are highly organ-dependent.
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Keywords | low-dose-rate γ-irradiation
forced swim test
antioxidant
oxidative stress
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2021-04
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Volume | volume75
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Issue | issue2
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Publisher | Okayama University Medical School
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Start Page | 169
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End Page | 175
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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