ID | 48556 |
FullText URL | |
Author |
Yoshimoto, Masaaki
Toyota, Teruaki
Taguchi, Takehito
Kaken ID
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Abstract | We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.
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Keywords | cold injury
brain edema
0.5 Gy irradiation
antioxidative function
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Published Date | 2012-02-01
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Publication Title |
Inflammation
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Volume | volume35
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Issue | issue1
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Publisher | Springer Science+Business Media, LLC
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Start Page | 89
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End Page | 97
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ISSN | 0360-3997
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Content Type |
Journal Article
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Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/48543
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language |
English
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Copyright Holders | © Springer Science+Business Media, LLC 2011
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File Version | author
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Refereed |
Unknown
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DOI | |
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