FullText URL fulltext.pdf
Author Ohtani, Tomoko| Kuroda, Shinji| Kanaya, Nobuhiko| Kakiuchi, Yoshihiko| Kumon, Kento| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Kikuchi, Satoru| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Oncolytic adenovirus p53 Dendritic cells Anti-tumor immunity Exosome
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-024-03849-5|
Published Date 2024-11-05
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 12
ISSN 1432-0851
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 39499326
DOI 10.1007/s00262-024-03849-5
Web of Science KeyUT 001350703400001
Related Url isVersionOf https://doi.org/10.1007/s00262-024-03849-5
FullText URL fulltext.pdf
Author Minagi, Hitoshi| Kanaya, Nobuhiko| Kondo, Yoshitaka| Kakiuchi, Yoshihiko| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Kikuchi, Satoru| Shigeyasu, Kunitoshi| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Myeloid sarcoma Chloroma Granulocytic sarcoma Bowel obstruction Abdominal pain
Note The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-024-02030-5|
Published Date 2024-10-04
Publication Title Surgical Case Reports
Volume volume10
Issue issue1
Publisher Springer
Start Page 229
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 39365540
DOI 10.1186/s40792-024-02030-5
Web of Science KeyUT 001326038200001
Related Url isVersionOf https://doi.org/10.1186/s40792-024-02030-5
Author LI, YUNCHENG| TAZAWA, HIROSHI| NAGAI, YASUO| FUJITA, SHUTO| OKURA, TOMOHIRO| SHOJI, RYOHEI| YAMADA, MOTOHIKO| KIKUCHI, SATORU| KURODA, SHINJI| OHARA, TOSHIAKI| NOMA, KAZUHIRO| NISHIZAKI, MASAHIKO| KAGAWA, SHUNSUKE| FUJIWARA, TOSHIYOSHI|
Keywords Gastric cancer peritoneal metastasis senescent fibroblast IL-8 CXCR1/2
Note This is an Accepted Manuscript of an article published by International Institute of Anticancer Research.| This fulltext file will be available in Dec. 2024.|
Published Date 2024-05-31
Publication Title Anticancer Research
Volume volume44
Issue issue6
Publisher International Institute of Anticancer Research
Start Page 2497
End Page 2509
ISSN 0250-7005
NCID AA10625860
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios)
File Version author
PubMed ID 38821603
DOI 10.21873/anticanres.17056
Web of Science KeyUT 001249685300009
Related Url isVersionOf https://doi.org/10.21873/anticanres.17056
Author Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi|
Note This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.|
Published Date 2024-04-15
Publication Title Nutrition and Cancer
Publisher Informa UK Limited
ISSN 0163-5581
NCID AA00325612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 38619145
DOI 10.1080/01635581.2024.2340782
Web of Science KeyUT 001202947500001
Related Url isVersionOf https://doi.org/10.1080/01635581.2024.2340782
JaLCDOI 10.18926/AMO/66924
FullText URL 78_2_151.pdf
Author Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Abstract Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
Keywords soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 151
End Page 161
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688833
Web of Science KeyUT 001229151800007
FullText URL fulltext.pdf
Author Kuroda, Shinji| Ishida, Michihiro| Choda, Yasuhiro| Muraoka, Atsushi| Hato, Shinji| Kagawa, Tetsuya| Tanaka, Norimitsu| Mitsuhashi, Toshiharu| Kakiuchi, Yoshihiko| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords anti-reflux surgery double-flap technique gastric cancer Kamikawa procedure proximal gastrectomy
Published Date 2024-02-22
Publication Title Annals of Gastroenterological Surgery
Volume volume8
Issue issue3
Publisher Wiley
Start Page 374
End Page 382
ISSN 2475-0328
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 38707222
DOI 10.1002/ags3.12783
Web of Science KeyUT 001174392500001
Related Url isVersionOf https://doi.org/10.1002/ags3.12783
FullText URL fulltext20240219-05.pdf
Author Hashimoto, Masashi| Kuroda, Shinji| Kanaya, Nobuhiko| Kadowaki, Daisuke| Yoshida, Yusuke| Sakamoto, Masaki| Hamada, Yuki| Sugimoto, Ryoma| Yagi, Chiaki| Ohtani, Tomoko| Kumon, Kento| Kakiuchi, Yoshihiko| Yasui, Kazuya| Kikuchi, Satoru| Yoshida, Ryuichi| Tazawa, Hiroshi| Kagawa, Shunsuke| Yagi, Takahito| Urata, Yasuo| Fujiwara, Toshiyoshi|
Note The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0|
Published Date 2024-02-05
Publication Title British Journal of Cancer
Volume volume130
Issue issue7
Publisher Springer Science and Business Media LLC
Start Page 1187
End Page 1195
ISSN 0007-0920
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38316993
DOI 10.1038/s41416-024-02583-0
Web of Science KeyUT 001156904400001
Related Url isVersionOf https://doi.org/10.1038/s41416-024-02583-0
FullText URL fulltext.pdf
Author Tamura, Shuta| Tazawa, Hiroshi| Hori, Naoto| Li, Yuncheng| Yamada, Motohiko| Kikuchi, Satoru| Kuroda, Shinji| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2023-11-16
Publication Title PLoS ONE
Volume volume18
Issue issue11
Publisher Public Library of Science
Start Page e0294491
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Tamura et al.
File Version publisher
PubMed ID 37972012
DOI 10.1371/journal.pone.0294491
Web of Science KeyUT 001119675000083
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0294491
FullText URL fulltext.pdf
Author Kakiuchi, Yoshihiko| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Gastric cancer (GC) elderly stage IA comorbidity Charlson comorbidity index (CCI)
Published Date 2022-10
Publication Title Journal of Gastrointestinal Oncology
Volume volume13
Issue issue5
Publisher AME Publishing Company
Start Page 2178
End Page 2185
ISSN 2078-6891
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Journal of Gastrointestinal Oncology.
File Version publisher
PubMed ID 36388703
DOI 10.21037/jgo-22-527
Web of Science KeyUT 000864732300001
Related Url isVersionOf https://doi.org/10.21037/jgo-22-527
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Kagawa, Shunsuke| Inoo, Shoko| Otsuka, Motoyuki|
Keywords immune checkpoint inhibitor chemotherapy-induced diarrhea immune-related adverse event colitis colonoscopy collagenous colitis
Published Date 2023-05-25
Publication Title Cureus
Volume volume15
Issue issue5
Publisher Springer
Start Page e39466
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Iwamuro et al.
File Version publisher
PubMed ID 37378156
DOI 10.7759/cureus.39466
Web of Science KeyUT 001023091300016
Related Url isVersionOf https://doi.org/10.7759/cureus.39466
FullText URL fulltext20230720-02.pdf fig20230720-02.pdf suppl_table20230720-02.pdf suppl_fig20230720-02.pdf
Author Yoshimoto, Masashi| Kagawa, Shunsuke| Kajioka, Hiroki| Taniguchi, Atsuki| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Yagi, Tomohiko| Nogi, Shohei| Teraishi, Fuminori| Shigeyasu, Kunitoshi| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jul. 2024.|
Published Date 2023-07-28
Publication Title Cancer Letters
Volume volume567
Publisher Elsevier BV
Start Page 216260
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 37295551
DOI 10.1016/j.canlet.2023.216260
Web of Science KeyUT 001020524700001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2023.216260
JaLCDOI 10.18926/AMO/65152
FullText URL 77_2_209.pdf
Author Sakamoto, Masaki| Teraishi, Fuminori| Shigeyasu Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival.
Keywords locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 209
End Page 213
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094960
Web of Science KeyUT 000982563800003
JaLCDOI 10.18926/AMO/64368
FullText URL 77_1_91.pdf
Author Takahashi, Toshiaki| Kakiuchi, Yoshihiko| Kikuch, Satoru| Kuroda, Shinji| Takeda, Sho| Shigeyasu, Kunitoshi| Kondo, Yoshitaka| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract An annular pancreas is a rare anomaly of the pancreas, defined as pancreatic tissue that totally or partly encircles the duodenum, usually the descending portion. A 76-year-old man who was diagnosed with gastric cancer cT3N0M0 Stage IIB underwent laparoscopic distal gastrectomy with D2 lymph node dissection. Intraoperatively, the dorsal half of the duodenal bulb was seen to be half surrounded by the pancreas, and a non-typical annular pancreas was diagnosed. Because of the risk to the pancreas, it was considered impossible to perform anastomosis by a linear stapler as in the usual laparoscopic procedure. Therefore, we performed laparoscopically assisted distal gastrectomy and Billroth-I reconstruction using a circular stapler, and the surgery was completed without difficulties. His postoperative course was good despite the development of a pancreatic fistula, which was an International Study Group for Pancreas Fistula biochemical leak. Some APs can be diagnosed preoperatively, but the rarer subtypes such as ours are more difficult to visualize on imaging. In gastrectomy, it is both oncologically important and technically challenging to perform lymph node dissection around the pancreas. In this case with an especially proximal pancreas, a circular stapler was considered better suited for gastroduodenal anastomosis and required a broader field than that afforded by laparoscopy. A case of non-typical annular pancreas diagnosed during laparoscopic gastric surgery is described.
Keywords annular pancreas gastric cancer laparoscopic distal gastrectomye
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 91
End Page 95
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849152
Web of Science KeyUT 000952978000002
FullText URL fulltext.pdf
Author Kakiuchi, Yoshihiko| Kikuchi, Satoru| Kuroda, Shinji| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Remnant gastric cancer Prognostic factor Tumor-infiltrating lymphocytes CD8(+) T cell Tumor immunity
Published Date 2022-11-30
Publication Title World Journal Of Surgical Oncology
Volume volume20
Issue issue1
Publisher BMC
Start Page 374
ISSN 1477-7819
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36451224
DOI 10.1186/s12957-022-02853-2
Web of Science KeyUT 000892980100002
Related Url isVersionOf https://doi.org/10.1186/s12957-022-02853-2
FullText URL fulltext.pdf
Author Sato, Hiroaki| Noma, Kazuhiro| Ohara, Toshiaki| Kawasaki, Kento| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Komoto, Satoshi| Kashima, Hajime| Katsura, Yuki| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi|
Published Date 2022-11-23
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 20152
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36418422
DOI 10.1038/s41598-022-24313-3
Web of Science KeyUT 000887936300054
Related Url isVersionOf https://doi.org/10.1038/s41598-022-24313-3
FullText URL fulltext.pdf
Author Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2022-12-15
Publication Title Molecular Therapy - Oncolytics
Volume volume27
Publisher Cell Press
Start Page 3
End Page 13
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 36212775
DOI 10.1016/j.omto.2022.09.003
Web of Science KeyUT 000870232500001
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.09.003
FullText URL fulltext.pdf
Author Komatsu, Yasuhiro| Shigeyasu, Kunitoshi| Yano, Shuya| Takeda, Sho| Takahashi, Kazutaka| Hata, Nanako| Umeda, Hibiki| Yoshida, Kazuhiro| Mori, Yoshiko| Yasui, Kazuya| Yoshida, Ryuichi| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Teraishi, Fuminori| Umeda, Yuzo| Kagawa, Shunsuke| Michiue, Hiroyuki| Tazawa, Hiroshi| Goel, Ajay| Fujiwara, Toshiyoshi|
Published Date 2022-08-08
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 13540
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © TheAuthor(s)2022
File Version publisher
PubMed ID 35941214
DOI 10.1038/s41598-022-17773-0
Web of Science KeyUT 000837764800013
Related Url isVersionOf https://doi.org/10.1038/s41598-022-17773-0
FullText URL fulltext.pdf
Author Teraishi, Fuminori| Shigeyasu, Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2022-05-01
Publication Title Journal Of Surgical Case Reports
Volume volume2022
Issue issue5
Publisher Oxford University Press
Start Page rjac101
ISSN 2042-8812
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35620231
DOI 10.1093/jscr/rjac101
Web of Science KeyUT 000799968300004
Related Url isVersionOf https://doi.org/10.1093/jscr/rjac101
FullText URL fulltext.pdf
Author Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Published Date 2022-06-16
Publication Title Molecular Therapy-Oncolytics
Volume volume25
Publisher Cell Press
Start Page 249
End Page 261
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35615263
DOI 10.1016/j.omto.2022.04.009
Web of Science KeyUT 000800437000008
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.04.009
FullText URL fulltext.pdf
Author Tazawa, Hiroshi| Shigeyasu, Kunitoshi| Noma, Kazuhiro| Kagawa, Shunsuke| Sakurai, Fuminori| Mizuguchi, Hiroyuki| Kobayashi, Hisataka| Imamura, Takeshi| Fujiwara, Toshiyoshi|
Keywords adenovirus EMT survivin telomerase vimentin
Published Date 2022-04-09
Publication Title Cancer Science
Publisher Wiley
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35398956
DOI 10.1111/cas.15369
Web of Science KeyUT 000783300600001
Related Url isVersionOf https://doi.org/10.1111/cas.15369