Kagawa, Shunsuke - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Senescent Fibroblasts Potentiate Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells via IL-8–mediated Crosstalk

Author	LI, YUNCHENG\| TAZAWA, HIROSHI\| NAGAI, YASUO\| FUJITA, SHUTO\| OKURA, TOMOHIRO\| SHOJI, RYOHEI\| YAMADA, MOTOHIKO\| KIKUCHI, SATORU\| KURODA, SHINJI\| OHARA, TOSHIAKI\| NOMA, KAZUHIRO\| NISHIZAKI, MASAHIKO\| KAGAWA, SHUNSUKE\| FUJIWARA, TOSHIYOSHI\|
Keywords	Gastric cancer peritoneal metastasis senescent fibroblast IL-8 CXCR1/2
Note	This is an Accepted Manuscript of an article published by International Institute of Anticancer Research.\| This fulltext file will be available in Dec. 2024.\|
Published Date	2024-05-31
Publication Title	Anticancer Research
Volume	volume44
Issue	issue6
Publisher	International Institute of Anticancer Research
Start Page	2497
End Page	2509
ISSN	0250-7005
NCID	AA10625860
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 International Institute of Anticancer Research (Dr. George J. Delinasios)
File Version	author
PubMed ID	38821603
DOI	10.21873/anticanres.17056
Web of Science KeyUT	001249685300009
Related Url	isVersionOf https://doi.org/10.21873/anticanres.17056

Perioperative and Postoperative Continuous Nutritional Counseling Improves Quality of Life of Gastric Cancer Patient Undergoing Gastrectomy

Author	Hanzawa, Shunya\| Kikuchi, Satoru\| Kuroda, Shinji\| Shoji, Ryohei\| Kashima, Hajime\| Matsumi, Yuki\| Takahashi, Ayako\| Kakiuchi, Yoshihiko\| Takagi, Kosei\| Tanabe, Shunsuke\| Noma, Kazuhiro\| Kagawa, Shunsuke\| Shikata, Kenichi\| Fujiwara, Toshiyoshi\|
Note	This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.\| This fulltext file will be available in Apr. 2025.\|
Published Date	2024-04-15
Publication Title	Nutrition and Cancer
Publisher	Informa UK Limited
ISSN	0163-5581
NCID	AA00325612
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	38619145
DOI	10.1080/01635581.2024.2340782
Web of Science KeyUT	001202947500001
Related Url	isVersionOf https://doi.org/10.1080/01635581.2024.2340782

p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression

JaLCDOI	10.18926/AMO/66924
FullText URL	78_2_151.pdf
Author	Komatsubara, Tadashi\| Tazawa, Hiroshi\| Hasei, Joe\| Omori, Toshinori\| Sugiu, Kazuhisa\| Mochizuki, Yusuke\| Demiya, Koji\| Yoshida, Aki\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Abstract	Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
Keywords	soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2024-04
Volume	volume78
Issue	issue2
Publisher	Okayama University Medical School
Start Page	151
End Page	161
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2024 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	38688833
Web of Science KeyUT	001229151800007

A multi-center, prospective, clinical study to evaluate the anti-reflux efficacy of laparoscopic double-flap technique (lD-FLAP Study)

FullText URL	fulltext.pdf
Author	Kuroda, Shinji\| Ishida, Michihiro\| Choda, Yasuhiro\| Muraoka, Atsushi\| Hato, Shinji\| Kagawa, Tetsuya\| Tanaka, Norimitsu\| Mitsuhashi, Toshiharu\| Kakiuchi, Yoshihiko\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Keywords	anti-reflux surgery double-flap technique gastric cancer Kamikawa procedure proximal gastrectomy
Published Date	2024-02-22
Publication Title	Annals of Gastroenterological Surgery
Volume	volume8
Issue	issue3
Publisher	Wiley
Start Page	374
End Page	382
ISSN	2475-0328
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Authors.
File Version	publisher
PubMed ID	38707222
DOI	10.1002/ags3.12783
Web of Science KeyUT	001174392500001
Related Url	isVersionOf https://doi.org/10.1002/ags3.12783

Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus

FullText URL	fulltext20240219-05.pdf
Author	Hashimoto, Masashi\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kadowaki, Daisuke\| Yoshida, Yusuke\| Sakamoto, Masaki\| Hamada, Yuki\| Sugimoto, Ryoma\| Yagi, Chiaki\| Ohtani, Tomoko\| Kumon, Kento\| Kakiuchi, Yoshihiko\| Yasui, Kazuya\| Kikuchi, Satoru\| Yoshida, Ryuichi\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Yagi, Takahito\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Note	The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0\|
Published Date	2024-02-05
Publication Title	British Journal of Cancer
Volume	volume130
Issue	issue7
Publisher	Springer Science and Business Media LLC
Start Page	1187
End Page	1195
ISSN	0007-0920
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38316993
DOI	10.1038/s41416-024-02583-0
Web of Science KeyUT	001156904400001
Related Url	isVersionOf https://doi.org/10.1038/s41416-024-02583-0

p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells

FullText URL	fulltext.pdf
Author	Tamura, Shuta\| Tazawa, Hiroshi\| Hori, Naoto\| Li, Yuncheng\| Yamada, Motohiko\| Kikuchi, Satoru\| Kuroda, Shinji\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2023-11-16
Publication Title	PLoS ONE
Volume	volume18
Issue	issue11
Publisher	Public Library of Science
Start Page	e0294491
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Tamura et al.
File Version	publisher
PubMed ID	37972012
DOI	10.1371/journal.pone.0294491
Web of Science KeyUT	001119675000083
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0294491

Prognostic risk factors for postoperative long-term outcomes in elderly stage IA gastric cancer patients

FullText URL	fulltext.pdf
Author	Kakiuchi, Yoshihiko\| Kuroda, Shinji\| Kikuchi, Satoru\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Keywords	Gastric cancer (GC) elderly stage IA comorbidity Charlson comorbidity index (CCI)
Published Date	2022-10
Publication Title	Journal of Gastrointestinal Oncology
Volume	volume13
Issue	issue5
Publisher	AME Publishing Company
Start Page	2178
End Page	2185
ISSN	2078-6891
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Journal of Gastrointestinal Oncology.
File Version	publisher
PubMed ID	36388703
DOI	10.21037/jgo-22-527
Web of Science KeyUT	000864732300001
Related Url	isVersionOf https://doi.org/10.21037/jgo-22-527

Collagenous Colitis in a Patient With Gastric Cancer Who Underwent Chemotherapy

FullText URL	fulltext.pdf
Author	Iwamuro, Masaya\| Tanaka, Takehiro\| Kagawa, Shunsuke\| Inoo, Shoko\| Otsuka, Motoyuki\|
Keywords	immune checkpoint inhibitor chemotherapy-induced diarrhea immune-related adverse event colitis colonoscopy collagenous colitis
Published Date	2023-05-25
Publication Title	Cureus
Volume	volume15
Issue	issue5
Publisher	Springer
Start Page	e39466
ISSN	2168-8184
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Iwamuro et al.
File Version	publisher
PubMed ID	37378156
DOI	10.7759/cureus.39466
Web of Science KeyUT	001023091300016
Related Url	isVersionOf https://doi.org/10.7759/cureus.39466

Dual antiplatelet therapy inhibits neutrophil extracellular traps to reduce liver micrometastases of intrahepatic cholangiocarcinoma

Author	Yoshimoto, Masashi\| Kagawa, Shunsuke\| Kajioka, Hiroki\| Taniguchi, Atsuki\| Kuroda, Shinji\| Kikuchi, Satoru\| Kakiuchi, Yoshihiko\| Yagi, Tomohiko\| Nogi, Shohei\| Teraishi, Fuminori\| Shigeyasu, Kunitoshi\| Yoshida, Ryuichi\| Umeda, Yuzo\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note	© 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Jul. 2024.\|
Published Date	2023-07-28
Publication Title	Cancer Letters
Volume	volume567
Publisher	Elsevier BV
Start Page	216260
ISSN	0304-3835
NCID	AA00598513
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Elsevier B.V.
File Version	author
PubMed ID	37295551
DOI	10.1016/j.canlet.2023.216260
Web of Science KeyUT	001020524700001
Related Url	isVersionOf https://doi.org/10.1016/j.canlet.2023.216260

Locally Advanced Rectal Cancer Invading the Gluteus Maximus Muscle Completely Responded to Total Neoadjuvant Therapy

JaLCDOI	10.18926/AMO/65152
FullText URL	77_2_209.pdf
Author	Sakamoto, Masaki\| Teraishi, Fuminori\| Shigeyasu Kunitoshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Abstract	A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival.
Keywords	locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2023-04
Volume	volume77
Issue	issue2
Publisher	Okayama University Medical School
Start Page	209
End Page	213
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2023 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	37094960
Web of Science KeyUT	000982563800003

A Case Report of Non-typical Annular Pancreas Diagnosed during Laparoscopic Gastric Surgery

JaLCDOI	10.18926/AMO/64368
FullText URL	77_1_91.pdf
Author	Takahashi, Toshiaki\| Kakiuchi, Yoshihiko\| Kikuch, Satoru\| Kuroda, Shinji\| Takeda, Sho\| Shigeyasu, Kunitoshi\| Kondo, Yoshitaka\| Teraishi, Fuminori\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Abstract	An annular pancreas is a rare anomaly of the pancreas, defined as pancreatic tissue that totally or partly encircles the duodenum, usually the descending portion. A 76-year-old man who was diagnosed with gastric cancer cT3N0M0 Stage IIB underwent laparoscopic distal gastrectomy with D2 lymph node dissection. Intraoperatively, the dorsal half of the duodenal bulb was seen to be half surrounded by the pancreas, and a non-typical annular pancreas was diagnosed. Because of the risk to the pancreas, it was considered impossible to perform anastomosis by a linear stapler as in the usual laparoscopic procedure. Therefore, we performed laparoscopically assisted distal gastrectomy and Billroth-I reconstruction using a circular stapler, and the surgery was completed without difficulties. His postoperative course was good despite the development of a pancreatic fistula, which was an International Study Group for Pancreas Fistula biochemical leak. Some APs can be diagnosed preoperatively, but the rarer subtypes such as ours are more difficult to visualize on imaging. In gastrectomy, it is both oncologically important and technically challenging to perform lymph node dissection around the pancreas. In this case with an especially proximal pancreas, a circular stapler was considered better suited for gastroduodenal anastomosis and required a broader field than that afforded by laparoscopy. A case of non-typical annular pancreas diagnosed during laparoscopic gastric surgery is described.
Keywords	annular pancreas gastric cancer laparoscopic distal gastrectomye
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2023-02
Volume	volume77
Issue	issue1
Publisher	Okayama University Medical School
Start Page	91
End Page	95
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2023 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	36849152
Web of Science KeyUT	000952978000002

Involvement in the tumor-infiltrating CD8(+) T cell expression by the initial disease of remnant gastric cancer

FullText URL	fulltext.pdf
Author	Kakiuchi, Yoshihiko\| Kikuchi, Satoru\| Kuroda, Shinji\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Keywords	Remnant gastric cancer Prognostic factor Tumor-infiltrating lymphocytes CD8(+) T cell Tumor immunity
Published Date	2022-11-30
Publication Title	World Journal Of Surgical Oncology
Volume	volume20
Issue	issue1
Publisher	BMC
Start Page	374
ISSN	1477-7819
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	36451224
DOI	10.1186/s12957-022-02853-2
Web of Science KeyUT	000892980100002
Related Url	isVersionOf https://doi.org/10.1186/s12957-022-02853-2

Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

FullText URL	fulltext.pdf
Author	Sato, Hiroaki\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kawasaki, Kento\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Komoto, Satoshi\| Kashima, Hajime\| Katsura, Yuki\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2022-11-23
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	20152
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	36418422
DOI	10.1038/s41598-022-24313-3
Web of Science KeyUT	000887936300054
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-24313-3

Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer

FullText URL	fulltext.pdf
Author	Araki, Hiroyuki\| Tazawa, Hiroshi\| Kanaya, Nobuhiko\| Kajiwara, Yoshinori\| Yamada, Motohiko\| Hashimoto, Masashi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2022-12-15
Publication Title	Molecular Therapy - Oncolytics
Volume	volume27
Publisher	Cell Press
Start Page	3
End Page	13
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	36212775
DOI	10.1016/j.omto.2022.09.003
Web of Science KeyUT	000870232500001
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2022.09.003

RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer

FullText URL	fulltext.pdf
Author	Komatsu, Yasuhiro\| Shigeyasu, Kunitoshi\| Yano, Shuya\| Takeda, Sho\| Takahashi, Kazutaka\| Hata, Nanako\| Umeda, Hibiki\| Yoshida, Kazuhiro\| Mori, Yoshiko\| Yasui, Kazuya\| Yoshida, Ryuichi\| Kondo, Yoshitaka\| Kishimoto, Hiroyuki\| Teraishi, Fuminori\| Umeda, Yuzo\| Kagawa, Shunsuke\| Michiue, Hiroyuki\| Tazawa, Hiroshi\| Goel, Ajay\| Fujiwara, Toshiyoshi\|
Published Date	2022-08-08
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	13540
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© TheAuthor(s)2022
File Version	publisher
PubMed ID	35941214
DOI	10.1038/s41598-022-17773-0
Web of Science KeyUT	000837764800013
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-17773-0

Anorectal leiomyoma with GLUT1 overexpression mimicking malignancy on FDG-PET/CT

FullText URL	fulltext.pdf
Author	Teraishi, Fuminori\| Shigeyasu, Kunitoshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2022-05-01
Publication Title	Journal Of Surgical Case Reports
Volume	volume2022
Issue	issue5
Publisher	Oxford University Press
Start Page	rjac101
ISSN	2042-8812
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	35620231
DOI	10.1093/jscr/rjac101
Web of Science KeyUT	000799968300004
Related Url	isVersionOf https://doi.org/10.1093/jscr/rjac101

Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of cancer

FullText URL	fulltext.pdf
Author	Ogawa, Toshihiro\| Kikuchi, Satoru\| Tabuchi, Motoyasu\| Mitsui, Ema\| Une, Yuta\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Published Date	2022-06-16
Publication Title	Molecular Therapy-Oncolytics
Volume	volume25
Publisher	Cell Press
Start Page	249
End Page	261
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	35615263
DOI	10.1016/j.omto.2022.04.009
Web of Science KeyUT	000800437000008
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2022.04.009

Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment

FullText URL	fulltext.pdf
Author	Tazawa, Hiroshi\| Shigeyasu, Kunitoshi\| Noma, Kazuhiro\| Kagawa, Shunsuke\| Sakurai, Fuminori\| Mizuguchi, Hiroyuki\| Kobayashi, Hisataka\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
Keywords	adenovirus EMT survivin telomerase vimentin
Published Date	2022-04-09
Publication Title	Cancer Science
Publisher	Wiley
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Authors.
File Version	publisher
PubMed ID	35398956
DOI	10.1111/cas.15369
Web of Science KeyUT	000783300600001
Related Url	isVersionOf https://doi.org/10.1111/cas.15369

Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells

JaLCDOI	10.18926/AMO/63425
FullText URL	76_2_203.pdf
Author	Masuda, Tomoya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Ieda, Takeshi\| Kikuchi, Satoru\| Kuroda, Shinji\| Noma, Kazuhiro\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Abstract	The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression.
Keywords	esophageal cancer EMT TGF-β oncolytic adenovirus E1A
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2022-04
Volume	volume76
Issue	issue2
Publisher	Okayama University Medical School
Start Page	203
End Page	215
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2022 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	35503449
Web of Science KeyUT	000792291900003

Surgical technique of suprapancreatic D2 lymphadenectomy focusing on the posterior hepatic plexus for advanced gastric cancer

FullText URL	fulltext20220131-2.pdf
Author	Kanaya, Nobuhiko\| Kuroda, Shinji\| Kakiuchi, Yoshihiko\| Takeda, Sho\| Kikuchi, Satoru\| Noma, Kazuhiro\| Yoshida, Ryuichi\| Umeda, Yuzo\| Teraishi, Fuminori\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Keywords	Gastric cancer D2 lymphadenectomy Suprapancreatic lymphadenectomy Posterior hepatic plexus Distal gastrectomy
Note	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00423-022-02437-4\|
Published Date	2022-1-12
Publication Title	Langenbeck's Archives of Surgery
Volume	volume407
Issue	issue2
Publisher	Springer Science and Business Media LLC
Start Page	871
End Page	877
ISSN	1435-2443
NCID	AA11211080
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version	author
PubMed ID	35022835
DOI	10.1007/s00423-022-02437-4
Web of Science KeyUT	000741939500003
Related Url	isVersionOf https://doi.org/10.1007/s00423-022-02437-4