ID | 64134 |
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Katayama, Yukitoshi
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi
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Miura, Ayane
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi
Sakamoto, Tatsuya
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi
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Takanami, Keiko
Mouse Genomics Resources Laboratory, National Institute of Genetics, Yata, Mishima
Sakamoto, Hirotaka
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Ushimado, Setouchi
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Abstract | The neural bases of itchy eye transmission remain unclear compared with those involved in body itch. Here, we show in rodents that the gastrin-releasing peptide receptor (GRPR) of the trigeminal sensory system is involved in the transmission of itchy eyes. Interestingly, we further demonstrate a difference in scratching behaviour between the left and right hindfeet in rodents; histamine instillation into the conjunctival sac of both eyes revealed right-foot biased laterality in the scratching movements. Unilateral histamine instillation specifically induced neural activation in the ipsilateral sensory pathway, with no significant difference between the activations following left- and right-eye instillations. Thus, the behavioural laterality is presumably due to right-foot preference in rodents. Genetically modified rats with specific depletion of Grpr-expressing neurons in the trigeminal sensory nucleus caudalis of the medulla oblongata exhibited fewer and shorter histamine-induced scratching movements than controls and eliminated the footedness. These results taken together indicate that the Grp-expressing neurons are required for the transmission of itch sensation from the eyes, but that foot preference is generated centrally. These findings could open up a new field of research on the mechanisms of the laterality in vertebrates and also offer new potential therapeutic approaches to refractory pruritic eye disorders.
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Keywords | itchy eyes
histamine
gastrin-releasing peptide receptor
footedness
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Published Date | 2022-10-19
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Publication Title |
Proceedings of the Royal Society B: Biological Sciences
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Volume | volume289
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Issue | issue1985
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Publisher | The Royal Society
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Start Page | 20221126
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ISSN | 0962-8452
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NCID | AA00786976
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2022 The Author(s)
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1098/rspb.2022.1126
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License | https://royalsociety.org/journals/ethics-policies/data-sharing-mining/
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