Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.

Nomoto, Hiroyuki; Oohashi, Toshitaka; Hirakawa, Satoshi; Ueki, Yasuyoshi; Ohtsuki, Hiroshi; Ninomiya, Yoshifumi

ID	31728
JaLCDOI	10.18926/AMO/31728
FullText URL	fulltext.pdf 919 KB
Author	Nomoto, Hiroyuki Oohashi, Toshitaka ORCID Kaken ID publons researchmap Hirakawa, Satoshi Ueki, Yasuyoshi Ohtsuki, Hiroshi Kaken ID publons researchmap Ninomiya, Yoshifumi Kaken ID publons
Abstract	We herein determined by fluorescence in situ hybridization the chromosomal localization of 2 human genes, BRAL1 and BCAN, both of which belong to the link-module superfamily, i.e. to the same band of chromosome 1q21-23. Further analysis of the genomic organization of BRAL1 and BCAN revealed that the BRAL1 gene was located 20-kb upstream of the BCAN start site. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the BCAN gene. High heterozygosity (0.79) makes this polymorphism a useful marker in the study of genetic disorders. Knowledge of the structure of the genes and the marker provides essential information for further analysis of the gene locus at chromosome 1q21-23.
Keywords	BRAL1 BCAN FISH schizophrenia polymorphic marker
Amo Type	Article
Publication Title	Acta Medica Okayama
Published Date	2002-02
Volume	volume56
Issue	issue1
Publisher	Okayama University Medical School
Start Page	25
End Page	29
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
File Version	publisher
Refereed	True
PubMed ID	11873941
Web of Science KeyUT	000174031300005