| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanaka, Shin| Nakata, Eiji| Ryuko, Tsuyoshi| Itano, Takuto| Tomioka, Yasuaki| Shien, Kazuhiko| Suzawa, Ken| Miyoshi, Kentaroh| Okazaki, Mikio| Sugimoto, Seiichiro| Ozaki, Toshifumi| Toyooka, Shinichi| |
| Keywords | Primary chest wall sarcomas Chest wall resection Chondrosarcoma Robust chest wall reconstruction |
| Published Date | 2025-04-01 |
| Publication Title | European Journal of Orthopaedic Surgery & Traumatology |
| Volume | volume35 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 141 |
| ISSN | 1432-1068 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40167819 |
| DOI | 10.1007/s00590-025-04260-1 |
| Web of Science KeyUT | 001459451400002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00590-025-04260-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tamura, Masanori| Furumatsu, Takayuki| Kitayama, Takahiro| Yokoyama, Yusuke| Okazaki, Yuki| Kawada, Koki| Ozaki, Toshifumi| |
| Keywords | Medial meniscus Posterior root tear Distance Pullout repair Second-look arthroscopy |
| Published Date | 2025-04-03 |
| Publication Title | Knee Surgery & Related Research |
| Volume | volume37 |
| Issue | issue1 |
| Publisher | Springer Nature |
| Start Page | 16 |
| ISSN | 2234-2451 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025. |
| File Version | publisher |
| PubMed ID | 40181486 |
| DOI | 10.1186/s43019-025-00264-7 |
| Web of Science KeyUT | 001459123500001 |
| Related Url | isVersionOf https://doi.org/10.1186/s43019-025-00264-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hasei, Joe| Hanzawa, Mana| Nagano, Akihito| Maeda, Naoko| Yoshida, Shinichirou| Endo, Makoto| Yokoyama, Nobuhiko| Ochi, Motoharu| Ishida, Hisashi| Katayama, Hideki| Fujiwara, Tomohiro| Nakata, Eiji| Nakahara, Ryuichi| Kunisada, Toshiyuki| Tsukahara, Hirokazu| Ozaki, Toshifumi| |
| Keywords | generative AI chatbot large language model pediatric cancer adolescent and young adult (AYA) psychological support |
| Published Date | 2025-02-25 |
| Publication Title | Frontiers in Digital Health |
| Volume | volume7 |
| Publisher | Frontiers Media |
| Start Page | 1543543 |
| ISSN | 2673-253X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Hasei, Hanzawa, Nagano, Maeda, Yoshida, Endo, Yokoyama, Ochi, Ishida, Katayama, Fujiwara, Nakata, Nakahara, Kunisada, Tsukahara and Ozaki. |
| File Version | publisher |
| PubMed ID | 40070545 |
| DOI | 10.3389/fdgth.2025.1543543 |
| Web of Science KeyUT | 001441098700001 |
| Related Url | isVersionOf https://doi.org/10.3389/fdgth.2025.1543543 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kunisada, Toshiyuki| Nakata, Eiji| Fujiwara, Tomohiro| Katayama, Haruyoshi| Itano, Takuto| Kurozumi, Takanao| Ando, Teruhiko| Ozaki, Toshifumi| |
| Keywords | unidirectional porous beta-tricalcium phosphate bone tumor bone graft radiography bone remodeling |
| Published Date | 2025-02-10 |
| Publication Title | Biomimetics |
| Volume | volume10 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 101 |
| ISSN | 2313-7673 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 39997124 |
| DOI | 10.3390/biomimetics10020101 |
| Web of Science KeyUT | 001430456900001 |
| Related Url | isVersionOf https://doi.org/10.3390/biomimetics10020101 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Naniwa, Shuichi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Ohtsuki, Takashi| Hotta, Yoshifumi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Otsuka, Noriaki| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress LRP4 Agrin β-catenin SOX9 |
| Published Date | 2025-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1007 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 39940775 |
| DOI | 10.3390/ijms26031007 |
| Web of Science KeyUT | 001418599900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26031007 |
| JaLCDOI | 10.18926/AMO/68360 |
|---|---|
| FullText URL | 79_1_039.pdf |
| Author | Takao, Shinichiro| Uotani, Koji| Misawa, Haruo| Tetsunaga, Tomoko| Shinohara, Kensuke| Yamane, Kentaro| Oda, Yoshiaki| Tsuji, Hironori| Kajiki, Yuya| Ozaki, Toshifumi| |
| Abstract | Evaluating vertebral bone mass and quality in the elderly poses challenges due to degenerative changes. This study aims to elucidate the usefulness of the trabecular bone score (TBS) by examining the relationship between bone mineral density (BMD), TBS, and Hounsfield unit (HU) values. A retrospective analysis of 599 vertebrae from 152 patients (mean age 69.0 years; range 44-89; 74 males and 78 females) undergoing dual-energy X-ray absorptiometry (DXA) and CT scans was conducted. Vertebrae were categorized into three grades based on the degree of degeneration. The TBS was calculated from DXA images, and the HU value was measured by placing a region of interest on an axial image of the vertebral mid-body. One-way analysis of variance and Pearson’s correlation tests were employed to investigate the relationship between BMD and TBS or HU values. While lumbar BMD significantly increased (p<0.01) with degenerative changes, TBS and HU values showed no significant differences. The correlations between lumbar BMD and TBS values, and between BMD and HU values, were stronger without degenerative changes than with degenerative changes. Significantly different HU values were observed between the right and left sides of severely degenerated vertebrae. Severe degenerative changes, particularly those associated with sclerosis, may impact HU values. TBS exhibits greater potential than HU values as a complementary tool. |
| Keywords | trabecular bone score computed tomography Hounsfield unit lumbar degenerative change radiodensity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 39 |
| End Page | 45 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012158 |
| Web of Science KeyUT | 001440463800005 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawada, Koki| Yokoyama, Yusuke| Okazaki, Yuki| Tamura, Masanori| Ozaki, Toshifumi| Furumatsu, Takayuki| |
| Keywords | healing status lateral wedge insole meniscus extrusion osteoarthritis posterior root tear |
| Published Date | 2025-01-20 |
| Publication Title | Journal of Experimental Orthopaedics |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e70141 |
| ISSN | 2197-1153 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 39839858 |
| DOI | 10.1002/jeo2.70141 |
| Web of Science KeyUT | 001400205300001 |
| Related Url | isVersionOf https://doi.org/10.1002/jeo2.70141 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hasei, Joe| Nakahara, Ryuichi| Otsuka, Yujiro| Nakamura, Yusuke| Ikuta, Kunihiro| Osaki, Shuhei| Hironari, Tamiya| Miwa, Shinji| Ohshika, Shusa| Nishimura, Shunji| Kahara, Naoaki| Yoshida, Aki| Fujiwara, Tomohiro| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | osteosarcoma medical image annotation anatomical annotation method rare cancer |
| Published Date | 2024-12-25 |
| Publication Title | Cancers |
| Volume | volume17 |
| Issue | issue1 |
| Publisher | MDPI |
| Start Page | 29 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 39796660 |
| DOI | 10.3390/cancers17010029 |
| Web of Science KeyUT | 001393409100001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers17010029 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Otani, Yusuke| Tanaka, Atsushi| Maekawa, Masaki| Peña, Tirso| Rogachevskaya, Anna| Ando, Teruhiko| Itano, Takuto| Katayama, Haruyoshi| Nakata, Eiji| Ozaki, Toshifumi| Toyooka, Shinichi| Doihara, Hiroyoshi| Roehrl, Michael H.| Fujimura, Atsushi| |
| Keywords | C1orf50 Luminal A breast cancer Cell cycle Immune evasion YAP/TAZ |
| Note | The version of record of this article, first published in Breast Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12282-024-01653-8| |
| Published Date | 2024-11-28 |
| Publication Title | Breast Cancer |
| Volume | volume32 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 292 |
| End Page | 305 |
| ISSN | 1340-6868 |
| NCID | AA1103354X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39604563 |
| DOI | 10.1007/s12282-024-01653-8 |
| Web of Science KeyUT | 001365140400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s12282-024-01653-8 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Futagawa, Mashu| Okazaki, Tetsuya| Nakata, Eiji| Fukano, Chika| Osumi, Risa| Kato, Fumino| Urakawa, Yusaku| Yamamoto, Hideki| Ozaki, Toshifumi| Hirasawa, Akira| |
| Note | The version of record of this article, first published in Human Genome Variation, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41439-024-00299-4| |
| Published Date | 2024-11-26 |
| Publication Title | Human Genome Variation |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 42 |
| ISSN | 2054-345X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39592598 |
| DOI | 10.1038/s41439-024-00299-4 |
| Web of Science KeyUT | 001363412200001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41439-024-00299-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Furumatsu, Takayuki| Kintaka, Keisuke| Higashihara, Naohiro| Tamura, Masanori| Kawada, Koki| Xue, Haowei| Ozaki, Toshifumi| |
| Keywords | Medial meniscus Posterior root Partial tear Meniscal extrusion Operative indication |
| Note | The version of record of this article, first published in Knee Surgery & Related Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s43019-023-00182-6| |
| Published Date | 2023-03-14 |
| Publication Title | Knee Surgery & Related Research |
| Volume | volume35 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 8 |
| ISSN | 2234-2451 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 36918982 |
| DOI | 10.1186/s43019-023-00182-6 |
| Web of Science KeyUT | 000949319200001 |
| Related Url | isVersionOf https://doi.org/10.1186/s43019-023-00182-6 |
| JaLCDOI | 10.18926/AMO/67655 |
|---|---|
| FullText URL | 78_5_357.pdf |
| Author | Yamawaki, Ryoko| Oda, Yoshiaki| Yamane, Shuhei| Uotani, Koji| Misawa, Haruo| Katayama, Yoshimi| Hamada, Masanori| Ozaki, Toshifumi| |
| Abstract | Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS. |
| Keywords | adolescent idiopathic scoliosis postural control coronal balance index of postural stability stabilometry |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-10 |
| Volume | volume78 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 357 |
| End Page | 362 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39467653 |
| Web of Science KeyUT | 001343346400001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Fujiwara, Tomohiro| Ueda, Koji| Yoshida, Aki| Iwata, Shintaro| Morita, Takuya| Kiyono, Masahiro| Kunisada, Toshiyuki| Takeda, Ken| Hasei, Joe| Yoshioka, Yusuke| Ochiya, Takahiro| Ozaki, Toshifumi| |
| Keywords | circulating biomarker Ewing sarcoma extracellular vesicles liquid biopsy proteome |
| Published Date | 2024-09-22 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue11 |
| Publisher | Wiley |
| Start Page | 3660 |
| End Page | 3671 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 39307979 |
| DOI | 10.1111/cas.16343 |
| Web of Science KeyUT | 001318444100001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16343 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hasei, Joe| Nakahara, Ryuichi| Otsuka, Yujiro| Nakamura, Yusuke| Hironari, Tamiya| Kahara, Naoaki| Miwa, Shinji| Ohshika, Shusa| Nishimura, Shunji| Ikuta, Kunihiro| Osaki, Shuhei| Yoshida, Aki| Fujiwara, Tomohiro| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | artificial intelligence clinical decision support diagnostic imaging image annotation osteosarcoma detection |
| Published Date | 2024-09-02 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue11 |
| Publisher | Wiley |
| Start Page | 3695 |
| End Page | 3704 |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 39223070 |
| DOI | 10.1111/cas.16330 |
| Web of Science KeyUT | 001302420900001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16330 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ueda, Masataka| Tetsunaga, Tomoko| Tetsunaga, Tomonori| Nishida, Keiichiro| Takatori, Ryo| Shitozawa, Hisakazu| Uotani, Koji| Shinohara, Kennsuke| Oda, Yoshiaki| Ozaki, Toshifumi| |
| Keywords | AIS cognitive-behavioral therapy EQ5D HADS insomnia pain-liaison outpatient clinic sleep disorders |
| Published Date | 2024-08-09 |
| Publication Title | Medicine |
| Volume | volume103 |
| Issue | issue32 |
| Publisher | Lippincott, Williams & Wilkins |
| Start Page | e39113 |
| ISSN | 0025-7974 |
| NCID | AA00728867 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 the Author(s). |
| File Version | publisher |
| PubMed ID | 39121265 |
| DOI | 10.1097/MD.0000000000039113 |
| Web of Science KeyUT | 001287977800045 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000039113 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hasei, Joe| Ishida, Hisashi| Katayama, Hideki| Maeda, Naoko| Nagano, Akihito| Ochi, Motoharu| Okamura, Masako| Iwata, Shintaro| Ikuta, Kunihiro| Yoshida, Shinichirou| Fujiwara, Tomohiro| Nakata, Eiji| Nakahara, Ryuichi| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | virtual reality metaverse adolescent and young adult rare cancer mental health |
| Published Date | 2024-07-23 |
| Publication Title | Cancers |
| Volume | volume16 |
| Issue | issue15 |
| Publisher | MDPI |
| Start Page | 2617 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 39123345 |
| DOI | 10.3390/cancers16152617 |
| Web of Science KeyUT | 001287028100001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers16152617 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kunisada, Toshiyuki| Nakata, Eiji| Fujiwara, Tomohiro| Hata, Toshiaki| Sato, Kohei| Katayama, Haruyoshi| Kondo, Ayana| Ozaki, Toshifumi| |
| Keywords | hydroxyapatite bone tumor orthopedic surgery unidirectional porous hydroxyapatite bone graft |
| Published Date | 2024-05-15 |
| Publication Title | Biomimetics |
| Volume | volume9 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 294 |
| ISSN | 2313-7673 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38786504 |
| DOI | 10.3390/biomimetics9050294 |
| Web of Science KeyUT | 001232206900001 |
| Related Url | isVersionOf https://doi.org/10.3390/biomimetics9050294 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Sugihara, Shinsuke| Nakahara, Ryuichi| Katayama, Haruyoshi| Itano, Takuto| Ozaki, Toshifumi| |
| Keywords | spinal metastases spinal instability neoplastic score radiotherapy posterolateral involvement of spinal elements risk factor |
| Published Date | 2024-04-30 |
| Publication Title | Cancer Control |
| Volume | volume31 |
| Publisher | SAGE Publications |
| ISSN | 1073-2748 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38686892 |
| DOI | 10.1177/10732748241250219 |
| Web of Science KeyUT | 001210831600001 |
| Related Url | isVersionOf https://doi.org/10.1177/10732748241250219 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Published Date | 2024-02-20 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue2 |
| Publisher | Public Library of Science |
| Start Page | e0298292 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Uotani et al. |
| File Version | publisher |
| PubMed ID | 38377118 |
| DOI | 10.1371/journal.pone.0298292 |
| Web of Science KeyUT | 001176939600021 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
