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Iwamuro, Masaya Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Kusumoto, Chiaki Department of Gastroenterology, Nippon Kokan Fukuyama Hospital
Nakagawa, Masahiro Department of Internal Medicine, Hiroshima City Hospital
Kobayashi, Sayo Department of Internal Medicine, Fukuyama City Hospital
Yoshioka, Masao Department of Internal Medicine, Okayama Saiseikai General Hospital
Inaba, Tomoki Department of Gastroenterology, Kagawa Prefectural Central Hospital
Toyokawa, Tatsuya Department of Gastroenterology, Fukuyama Medical Center
Hori, Shinichiro Department of Endoscopy, National Hospital Organization Shikoku Cancer Center
Tanaka, Shouichi Department of Gastroenterology, Iwakuni Clinical Center
Matsueda, Kazuhiro Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Tanaka, Takehiro Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences ORCID Kaken ID publons
Okada, Hiroyuki Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Abstract
The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of oxyntic gland adenomas and GA-FG was approximately equal. The majority of the lesions were resected by endoscopic mucosal resection using a diathermic snare (EMR, n=42) or endoscopic submucosal dissection (ESD, n=72). Histologically, there were no lesions with invasion at the level of the muscularis propria or deeper, and lymphovascular invasion was present in 1.6%. Of the ESD and EMR specimens, there were no lesions that were positive for vertical margins. Among the eight GA-FG patients with deep (>= 500 mu m) submucosal invasion, six were treated with endoscopic resection alone, and no recurrence was documented. No patients died of the disease during the median follow-up period of 14.5 months. In conclusion, all lesions were confined to the mucosa or submucosa and were negative for vertical margins. Lymphovascular invasion was present in only 1.6% of the patients. Thus, we believe that endoscopic resection is a suitable initial treatment method for oxyntic gland adenoma and GA-FG.
Published Date
2021-04-01
Publication Title
Scientific Reports
Volume
volume11
Issue
issue1
Publisher
Nature Research
ISSN
2045-2322
Content Type
Journal Article
language
English
OAI-PMH Set
岡山大学
Copyright Holders
© The Author(s) 2021
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PubMed ID
NAID
DOI
Web of Science KeyUT
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isVersionOf https://doi.org/10.1038/s41598-021-86893-w
License
http://creativecommons.org/licenses/by/4.0/