ID | 61911 |
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Iwamuro, Masaya
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Kusumoto, Chiaki
Department of Gastroenterology, Nippon Kokan Fukuyama Hospital
Nakagawa, Masahiro
Department of Internal Medicine, Hiroshima City Hospital
Kobayashi, Sayo
Department of Internal Medicine, Fukuyama City Hospital
Yoshioka, Masao
Department of Internal Medicine, Okayama Saiseikai General Hospital
Inaba, Tomoki
Department of Gastroenterology, Kagawa Prefectural Central Hospital
Toyokawa, Tatsuya
Department of Gastroenterology, Fukuyama Medical Center
Hori, Shinichiro
Department of Endoscopy, National Hospital Organization Shikoku Cancer Center
Tanaka, Shouichi
Department of Gastroenterology, Iwakuni Clinical Center
Matsueda, Kazuhiro
Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Tanaka, Takehiro
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Okada, Hiroyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of oxyntic gland adenomas and GA-FG was approximately equal. The majority of the lesions were resected by endoscopic mucosal resection using a diathermic snare (EMR, n=42) or endoscopic submucosal dissection (ESD, n=72). Histologically, there were no lesions with invasion at the level of the muscularis propria or deeper, and lymphovascular invasion was present in 1.6%. Of the ESD and EMR specimens, there were no lesions that were positive for vertical margins. Among the eight GA-FG patients with deep (>= 500 mu m) submucosal invasion, six were treated with endoscopic resection alone, and no recurrence was documented. No patients died of the disease during the median follow-up period of 14.5 months. In conclusion, all lesions were confined to the mucosa or submucosa and were negative for vertical margins. Lymphovascular invasion was present in only 1.6% of the patients. Thus, we believe that endoscopic resection is a suitable initial treatment method for oxyntic gland adenoma and GA-FG.
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Published Date | 2021-04-01
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Publication Title |
Scientific Reports
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Volume | volume11
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Issue | issue1
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Publisher | Nature Research
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ISSN | 2045-2322
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © The Author(s) 2021
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.1038/s41598-021-86893-w
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License | http://creativecommons.org/licenses/by/4.0/
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