| ID | 61048 |
| FullText URL | |
| Author |
Shahriar, Abu Saleh Muhammad
Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ono, Shintaro
Department of Periodontal Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nakayama, Masaaki
Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ohara, Naoko
Department of Operative Dentistry, Okayama University Hospital, Okayama University
Ohara, Naoya
Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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| Abstract | The periodontal pathogen Porphyromonas gingivalis produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in the organism's virulence, and pigmentation. We previously showed that deletion of the PGN_0297 and PGN_0300 genes reduced the proteolytic activity of gingipains. The role of the PGN_0296 gene, consisting of an operon with the PGN_0297 and PGN_0300 genes, is unclear. Herein, we examined the effect of PGN_0296 gene deletion on the proteolytic activity. Although the proteolytic activity of the gingipains did not decrease in the culture supernatant of a PGN_0296 gene deletion mutant (ΔPGN_0296), the growth was delayed.
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| Keywords | Porphyromonas gingivalis
Periodontal diseases
Gingipain
Bacterial secretion system
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| Note | © 2020 Japanese Association for Oral Biology. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.job.2020.09.007] .
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| Published Date | 2020-12
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| Publication Title |
Journal of Oral Biosciences
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| Volume | volume62
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| Issue | issue4
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| Publisher | Elsevier
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| Start Page | 322
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| End Page | 326
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| ISSN | 1349-0079
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| NCID | AA11896386
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2020 Japanese Association for Oral Biology.
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| File Version | author
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| PubMed ID | |
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| Web of Science KeyUT | |
| Related Url | isVersionOf https://doi.org/10.1016/j.job.2020.09.007
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| License | https://creativecommons.org/licenses/by-nc-nd/4.0/
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| Funder Name |
Japan Society for the Promotion of Science
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| 助成番号 | 17H04378
26861573
17K11668
20K09939
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