ID | 40008 |
JaLCDOI | |
FullText URL | |
Author |
Hirai, Kazuyuki
Arimitsu, Hideyuki
Umeda, Koji
Shen, Lianhua
Ayada, Kiyoshi
Kodama, Yoshikatsu
Tsuji, Takao
Hirai, Yoshikazu
Oguma, Keiji
Kaken ID
researchmap
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Abstract | In an attempt to prepare egg yolk immunoglobulin (IgY) to treat and prevent cholera, hens were immunized by a mixture of heat- or formalin-killed Vibrio cholerae O1 and O139 organisms, or by the recombinant cholera toxin B subunit (CTB). The IgYs were partially purified from egg yolk and orally administered to suckling mice before or after challenge with live O1 or O139 cells. The anti-O1 and O139 IgYs and the mixture of either IgY with anti-CTB IgY significantly protected the occurrence of cholera caused by both O1 and O139 infection. Since large amounts of IgY can be prepared very easily and at low cost, this seems to be a useful procedure for preventing and treating cholera.
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Keywords | Vibrio cholerae
O1
O139
IgY
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2010-06
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Volume | volume64
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Issue | issue3
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Publisher | Okayama University Medical School
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Start Page | 163
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End Page | 170
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |