ID | 57570 |
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Author |
MIZUNO, HIROFUMI
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
MIYAI, HISATAKA
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
YOKOI, AYA
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
KOBAYASHI, TERUMASA
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
INABU, CHIAKI
Junpukai Daiku Dental Clinic
MARUYAMA, TAKAYUKI
Center for Innovative Clinical Medicine, Okayama University Hospital
EKUNI, DAISUKE
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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MIZUKAWA, NOBUYOSHI
Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Hospital
KARIYA, SHIN
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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NISHIZAKI, KAZUNORI
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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KIMATA, YOSHIHIRO
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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MORITA, MANABU
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | BACKGROUND/AIM:
The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. PATIENTS AND METHODS: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. RESULTS: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). CONCLUSION: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM. |
Keywords | Head and neck cancer
concurrent chemoradiotherapy
creatinine clearance
oral mucositis
renal dysfunction
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Published Date | 2019-01
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Publication Title |
In Vivo
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Volume | volume33
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Issue | issue1
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Publisher | The International Institute of Anticancer Research
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Start Page | 183
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End Page | 189
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ISSN | 0258-851X
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | publisher
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DOI | |
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Related Url | isVersionOf https://doi.org/10.21873/invivo.11457
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