ID | 66663 |
FullText URL | |
Author |
Iijima, Yuta
Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Miki, Ryohei
Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Fujimura, Masatake
Department of Basic Medical Science, National Institute for Minamata Disease
Oyadomari, Seiichi
Division of Molecular Biology, Institute of Advanced Medical Sciences, Tokushima University
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Abstract | Apoptosis is one of the hallmarks of MeHg-induced neuronal cell death; however, its molecular mechanism remains unclear. We previously reported that MeHg exposure induces neuron-specific ER stress in the mouse brain. Excessive ER stress contributes to apoptosis, and CHOP induction is considered to be one of the major mechanisms. CHOP is also increased by MeHg exposure in the mouse brain, suggesting that it correlates with increased apoptosis. In this study, to clarify whether CHOP mediates MeHg-induced apoptosis, we examined the effect of CHOP deletion on MeHg exposure in CHOP-knockout mice. Our data showed that CHOP deletion had no effect on MeHg exposure-induced weight loss or hindlimb impairment in mice, nor did it increase apoptosis or inhibit neuronal cell loss. Hence, CHOP plays little role in MeHg toxicity, and other apoptotic pathways coupled with ER stress may be involved in MeHg-induced cell death.
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Keywords | Methylmercury
Neuronal cell death
Apoptosis
CHOP
Knockout mouse
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Published Date | 2024
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Publication Title |
The Journal of Toxicological Sciences
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Volume | volume49
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Issue | issue2
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Publisher | Japanese Society of Toxicology
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Start Page | 55
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End Page | 60
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ISSN | 0388-1350
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NCID | AN00002808
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2024 The Japanese Society of Toxicology
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File Version | publisher
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PubMed ID | |
DOI | |
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Related Url | isVersionOf https://doi.org/10.2131/jts.49.55
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Funder Name |
Japan Science and Technology Agency
Ministry of the Environment
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助成番号 | JPMJFS2128
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