| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujii, Yuki| Matsumoto, Kazuyuki| Matsumi, Akihiro| Miyamoto, Kazuya| Uchida, Daisuke| Horiguchi, Shigeru| Tsutsumi, Koichiro| Mitsuhashi, Toshiharu| Otsuka, Motoyuki| |
| Keywords | adverse events balloon-assisted ERCP benzodiazepine sedation |
| Published Date | 2025-03-27 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume14 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 2287 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40217737 |
| DOI | 10.3390/jcm14072287 |
| Web of Science KeyUT | 001463583200001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm14072287 |
| JaLCDOI | 10.18926/interdisciplinary/68626 |
|---|---|
| Title Alternative | Practical BIZEN Device Design Course Activity Report in Fiscal 2024 |
| FullText URL | interdisciplinary_5_47.pdf |
| Author | TSUZUKI, Tsuneaki| UCHIDA, Daisuke| KISHIMOTO, Toshio| SENGOKU, Yoshinari| KORENAGA, Toshio| HITOBE, Yu| YOSHIBA, Yasuyuki| SAKURAI, Jun| |
| Publication Title | Interdisciplinary Science |
| Published Date | 2025-03-31 |
| Volume | volume5 |
| Start Page | 47 |
| End Page | 55 |
| ISSN | 2436-3227 |
| language | Japanese |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujii, Yuki| Matsumoto, Kazuyuki| Ochi, Kiyoaki| Himei, Hitomi| Sakakihara, Ichiro| Ueta, Eijiro| Toyokawa, Tatsuya| Harada, Ryo| Ogawa, Taiji| Tomoda, Takeshi| Kato, Hironari| Sato, Ryosuke| Obata, Taisuke| Matsumi, Akihiro| Miyamoto, Kazuya| Uchida, Daisuke| Horiguchi, Shigeru| Tsutsumi, Koichiro| Otsuka, Motoyuki| |
| Keywords | clipping closure delayed bleeding endoscopic papillectomy |
| Published Date | 2025 |
| Publication Title | Therapeutic Advances in Gastroenterology |
| Volume | volume18 |
| Publisher | SAGE Publications |
| ISSN | 1756-2848 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), 2025. |
| File Version | publisher |
| PubMed ID | 40104325 |
| DOI | 10.1177/17562848251326450 |
| Web of Science KeyUT | 001447404800001 |
| Related Url | isVersionOf https://doi.org/10.1177/17562848251326450 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kajitani, Satoshi| Matsumoto, Kazuyuki| Oki, Kentaro| Matsumi, Akihiro| Miyamoto, Kazuya| Fujii, Yuki| Uchida, Daisuke| Tsutsumi, Koichiro| Horiguchi, Shigeru| Otsuka, Motoyuki| |
| Keywords | endoscopic introducer endoscopic ultrasonography-guided pancreatic duct drainage endosonographically/EUS-guided created route EUS-guided interventions internal stent |
| Published Date | 2025-03-11 |
| Publication Title | DEN Open |
| Volume | volume5 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e70096 |
| ISSN | 2692-4609 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40070932 |
| DOI | 10.1002/deo2.70096 |
| Web of Science KeyUT | 001441089300001 |
| Related Url | isVersionOf https://doi.org/10.1002/deo2.70096 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Kazuyuki| Uchida, Daisuke| Takeuchi, Yasuto| Kato, Hironari| Fujii, Yuki| Harada, Kei| Hattori, Nao| Sato, Ryosuke| Obata, Taisuke| Matsumi, Akihiro| Miyamoto, Kazuya| Horiguchi, Shigeru| Tsutsumi, Koichiro| Yasui, Kazuya| Harada, Ryo| Fujii, Masakuni| Otsuka, Motoyuki| |
| Keywords | ablation techniques endosonography neuroendocrine tumors pancreatic neoplasms pilot projects |
| Published Date | 2025-01-29 |
| Publication Title | DEN Open |
| Volume | volume5 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e70073 |
| ISSN | 2692-4609 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 39885893 |
| DOI | 10.1002/deo2.70073 |
| Web of Science KeyUT | 001408662000001 |
| Related Url | isVersionOf https://doi.org/10.1002/deo2.70073 |
| Author | Sato, Ryosuke| Matsumoto, Kazuyuki| Kinugasa, Hideaki| Tomiya, Masahiro| Tanimoto, Takayoshi| Ohto, Akimitsu| Harada, Kei| Hattori, Nao| Obata, Taisuke| Matsumi, Akihiro| Miyamoto, Kazuya| Morimoto, Kosaku| Terasawa, Hiroyuki| Fujii, Yuki| Uchida, Daisuke| Tsutsumi, Koichiro| Horiguchi, Shigeru| Kato, Hironari| Kawahara, Yoshiro| Otsuka, Motoyuki| |
|---|---|
| Note | © 2024 by the American Society for Gastrointestinal Endoscopy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Nov. 2025.| |
| Published Date | 2024-06-13 |
| Publication Title | Gastrointestinal Endoscopy |
| Volume | volume100 |
| Issue | issue5 |
| Publisher | Elsevier |
| Start Page | 938 |
| End Page | 946.e1 |
| ISSN | 0016-5107 |
| NCID | AA00653961 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the American Society for Gastrointestinal Endoscopy |
| File Version | author |
| PubMed ID | 38879044 |
| DOI | 10.1016/j.gie.2024.06.013 |
| Web of Science KeyUT | 001355734600001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.gie.2024.06.013 |
| JaLCDOI | 10.18926/interdisciplinary/66897 |
|---|---|
| Title Alternative | Practical BIZEN Device Design Course Activity Report in Fiscal 2023 |
| FullText URL | interdisciplinary_4_41.pdf |
| Author | KORENAGA, Toshio| UCHIDA, Daisuke| KISHIMOTO, Toshio| SENGOKU, Yoshinari| OKA, Hisao| TSUZUKI, Tsuneaki| YOSHIBA, Yasuyuki| SAKURAI, Jun| |
| Publication Title | Interdisciplinary Science |
| Published Date | 2024-03-31 |
| Volume | volume4 |
| Start Page | 41 |
| End Page | 49 |
| ISSN | 2436-3227 |
| language | Japanese |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Obata, Taisuke| Tsutsumi, Koichiro| Ueta, Eijiro| Oda, Takashi| Kikuchi, Tatsuya| Ako, Soichiro| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Kato, Hironari| Okada, Hiroyuki| Otsuka, Motoyuki| |
| Published Date | 2023-12-12 |
| Publication Title | Molecular Therapy Nucleic Acids |
| Volume | volume34 |
| Publisher | Cell Press |
| Start Page | 102054 |
| ISSN | 2162-2531 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 38111913 |
| DOI | 10.1016/j.omtn.2023.102054 |
| Web of Science KeyUT | 001146413100001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omtn.2023.102054 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyamoto, Kazuya| Matsumoto, Kazuyuki| Obata, Taisuke| Sato, Ryosuke| Matsumi, Akihiro| Morimoto, Kosaku| Ogawa, Taiji| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Horiguchi, Shigeru| Tsutsumi, Koichiro| Kato, Hironari| Otsuka, Motoyuki| |
| Keywords | Balloon-assisted endoscopy Propofol Diazepam Sedation |
| Note | The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-023-02936-8| |
| Published Date | 2023-09-04 |
| Publication Title | BMC Gastroenterology |
| Volume | volume23 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 296 |
| ISSN | 1471-230X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37667224 |
| DOI | 10.1186/s12876-023-02936-8 |
| Web of Science KeyUT | 001063014700002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-023-02936-8 |
| JaLCDOI | 10.18926/AMO/65494 |
|---|---|
| FullText URL | 77_3_291.pdf |
| Author | Himei, Hitomi| Kato, Hironari| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Abstract | We investigated the efficacy and safety of endoscopic plastic stent (PS) placement for hilar benign biliary strictures (BBSs) and compared cases with PS placement above (inside stent, IS) and across (usual stent, US) the sphincter of Oddi. Patients who underwent initial endoscopic PS placement for hilar BBSs between August 2012 and December 2021 were retrospectively analyzed. Hilar BBSs in 88 patients were investigated. Clinical success was achieved in 81 of these cases (92.0%), including 38 patients in the IS group and 43 patients in the US group. Unexpected stent exchange (uSE) before the first scheduled PS exchange occurred in 18 cases (22.2%). The median time from first stent placement to uSE was 35 days. There was no significant difference in the rate and median time to uSE between the two groups. The rates of adverse events such as pancreatitis or cholangitis in the two groups did not significantly differ. However, the rate of difficult stent removal in the IS group (15.8%) was significantly higher than that in the US group (0%) (p=0.0019). US placement is preferable to IS placement for scheduled stent exchange, as it offers the same effectiveness and risk of adverse events with easier stent removal. |
| Keywords | benign biliary stricture inside stent plastic stent |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 291 |
| End Page | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357630 |
| Web of Science KeyUT | 001026279600007 |
| FullText URL | fulltext20221130-3.pdf |
|---|---|
| Author | Sato, Ryosuke| Matsumoto, Kazuyuki| Kanzaki, Hiromitsu| Matsumi, Akihiro| Miyamoto, Kazuya| Morimoto, Kosaku| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tsutsumi, Koichiro| Horiguchi, Shigeru| Kato, Hironari| |
| Keywords | Endoscopic ultrasound-guided fine needle aspiration Linitis plastica Autoimmune pancreatitis Paraneoplastic syndromes Case report |
| Note | Sato R, Matsumoto K, Kanzaki H, Matsumi A, Miyamoto K, Morimoto K, Terasawa H, Fujii Y, Yamazaki T, Uchida D, Tsutsumi K, Horiguchi S, Kato H. Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report. World J Clin Cases 2022; 10(31): 11607-11616 [PMID: 36387831 DOI: 10.12998/wjcc.v10.i31.11607]| |
| Published Date | 2022-11-6 |
| Publication Title | World Journal of Clinical Cases |
| Volume | volume10 |
| Issue | issue31 |
| Publisher | Baishideng Publishing Group Inc. |
| Start Page | 11607 |
| End Page | 11616 |
| ISSN | 2307-8960 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36387831 |
| DOI | 10.12998/wjcc.v10.i31.11607 |
| Web of Science KeyUT | 000885256200043 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamazaki, Tatsuhiro| Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuki| Saragai, Yosuke| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Keywords | surveillance prognosis factor intraductal papillary mucinous neoplasm pancreatic cancer |
| Published Date | 2021-10-15 |
| Publication Title | Internal Medicine |
| Volume | volume60 |
| Issue | issue20 |
| Publisher | The Japanese Society of Internal Medicine |
| Start Page | 3205 |
| End Page | 3211 |
| ISSN | 0918-2918 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 33967138 |
| DOI | 10.2169/internalmedicine.7168-21 |
| Web of Science KeyUT | 000709798800002 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.7168-21 |
| FullText URL | fulltext.pdf Fig1-5.pdf |
|---|---|
| Author | Matsumoto, Kazuyuki| Kato, Hironari| Horiguchi, Shigeru| Uchida, Daisuke| Tomoda, Takeshi| Muro, Shinichiro| Okada, Hiroyuki| |
| Published Date | 2019-09 |
| Publication Title | Endoscopy |
| Volume | volume51 |
| Issue | issue9 |
| Publisher | Thieme Gruppe |
| Start Page | E265 |
| End Page | E266 |
| ISSN | 0013-726X |
| NCID | AA00635110 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31071749 |
| DOI | 10.1055/a-0896-2498 |
| Web of Science KeyUT | 000484585300014 |
| Related Url | isVersionOf https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0896-2498 |
| FullText URL | fulltext.pdf Fig_1-4.pdf |
|---|---|
| Author | Ishihara, Yuki| Matsumoto, Kazuyuki| Kato, Hironari| Tsutsumi, Koichiro| Tomoda, Takeshi| Matsumi, Akihiro| Miyamoto, Kazuya| Yamazaki, Tatsuhiro| Saragai, Yosuke| Fujii, Yuki| Uchida, Daisuke| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Keywords | Peroral direct cholangioscopy Hepatolithiasis Altered gastrointestinal anatomy Double-balloon endoscopy |
| Note | This is an Accepted Manuscript of an article published by Springer.| |
| Published Date | 2020-11-02 |
| Publication Title | Surgical Endoscopy |
| Volume | volume35 |
| Publisher | Springer |
| Start Page | 1895 |
| End Page | 1902 |
| ISSN | 0930-2794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33140150 |
| DOI | 10.1007/s00464-020-08139-6 |
| Web of Science KeyUT | 000584333800003 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-020-08139-6 |
| FullText URL | fulltext.pdf Figure.tif |
|---|---|
| Author | Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Keywords | diclofenac low dose post‐ERCP pancreatitis |
| Note | This is the peer reviewed version of the following article: Takeshi Tomoda et. al. Efficacy of low dose rectal diclofenac for preventing post‐endoscopic retrograde cholangiopancreatography pancreatitis: Propensity score‐matched analysis. Digestive Endoscopy, which has been published in final form at https://doi.org/10.1111/den.13828. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2020-09-02 |
| Publication Title | Digestive Endoscopy |
| Volume | volume33 |
| Publisher | Wiley |
| Start Page | 656 |
| End Page | 662 |
| ISSN | 0915-5635 |
| NCID | AA10907137 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32881078 |
| DOI | 10.1111/den.13828 |
| Web of Science KeyUT | 000577757600001 |
| Related Url | isVersionOf https://doi.org/10.1111/den.13828 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyamoto, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Inoue, Hirohumi| Tanaka, Takehiro| Matsumi, Akihiro| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tomoda, Takeshi| Horiguchi, Shigeru| Yagi, Takahito| Okada, Hiroyuki| |
| Keywords | IPMN PJC LBC BD SurePath |
| Published Date | 2020-09-29 |
| Publication Title | BMC Gastroenterology |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 319 |
| ISSN | 1471-230X |
| NCID | AA12034934 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 32993498 |
| DOI | 10.1186/s12876-020-01465-y |
| Web of Science KeyUT | 000576989100004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-020-01465-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Kazuyuki| Kato, Hironari| Horiguchi, Shigeru| Tomoda, Takeshi| Matsumi, Akihiro| Ishihara, Yuki| Saragai, Yosuke| Takada, Saimon| Muro, Shinichiro| Uchida, Daisuke| Okada, Hiroyuki| |
| Keywords | Endoscopic ultrasound-guided fine needle aspiration Pancreaticobiliary cancer Neoplasm recurrence |
| Published Date | 2020 |
| Publication Title | Gut and Liver |
| Volume | volume14 |
| Issue | issue5 |
| Publisher | Gut and Liver |
| Start Page | 652 |
| End Page | 658 |
| ISSN | 1976-2283 |
| NCID | AA12329814 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31818050 |
| NAID | 120006891207 |
| DOI | 10.5009/gnl19200 |
| Web of Science KeyUT | 000569359000016 |
| Related Url | isVersionOf https://doi.org/10.5009/gnl19200 |
| JaLCDOI | 10.18926/AMO/60364 |
|---|---|
| FullText URL | 74_4_275.pdf |
| Author | Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment. |
| Keywords | oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 275 |
| End Page | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843758 |
| Web of Science KeyUT | 000562508700002 |
| NAID | 120006880203 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uchida, Daisuke| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Okada, Hiroyuki| |
| Keywords | oxidative stress chronic hepatitis hepatocellular carcinoma |
| Published Date | 2020-05-28 |
| Publication Title | Nutrients |
| Volume | volume12 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 1576 |
| ISSN | 2072-6643 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32481552 |
| DOI | 10.3390/nu12061576 |
| Web of Science KeyUT | 000554005200001 |
| Related Url | isVersionOf https://doi.org/10.3390/nu12061576 |
| JaLCDOI | 10.18926/AMO/59957 |
|---|---|
| FullText URL | 74_3_237.pdf |
| Author | Oyama, Atsushi| Uchida, Daisuke| Shiraha, Hidenori| Sawahara, Hiroaki| Kato, Ryo| Iwamuro, Masaya| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Abstract | The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC. |
| Keywords | enzyme-linked immunosorbent assay liver resection primary radiofrequency ablation Huh7 Hep3B |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-06 |
| Volume | volume74 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 237 |
| End Page | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32577022 |
| Web of Science KeyUT | 000543363400007 |
| NAID | 120006862798 |
