FullText URL | fulltext.pdf |
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Author | Hassan, Ghmkin| Afify, Said M.| Zahra, Maram H.| Nawara, Hend M.| Kumon, Kazuki| Iwasaki, Yoshiaki| Salomon, David S.| Seno, Akimasa| Seno, Masaharu| |
Keywords | Cancer stem cells Human iPSCs Signal pathway inhibitors Tumor initiation |
Note | The version of record of this article, first published in Cytotechnology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10616-023-00575-1| |
Published Date | 2023-04-01 |
Publication Title | Cytotechnology |
Volume | volume75 |
Issue | issue3 |
Publisher | Springer Science and Business Media LLC |
Start Page | 243 |
End Page | 253 |
ISSN | 0920-9069 |
NCID | AA10678299 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023 |
File Version | publisher |
PubMed ID | 37181678 |
DOI | 10.1007/s10616-023-00575-1 |
Web of Science KeyUT | 000961388400001 |
Related Url | isVersionOf https://doi.org/10.1007/s10616-023-00575-1 |
FullText URL | fulltext.pdf |
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Author | Higuchi, Chigusa| Matsumoto, Naomi| Iwasaki, Yoshiaki| Yorifuji, Takashi| Yamazaki, Junichiro| Nasu, Yasutomo| Makino, Hirofumi| |
Keywords | COVID-19 vaccine vaccine hesitancy young adults information literacy satisfaction |
Published Date | 2022-01-30 |
Publication Title | Journal of Disaster Research |
Volume | volume17 |
Issue | issue1 |
Publisher | Fuji Technology Press Ltd. |
Start Page | 21 |
End Page | 30 |
ISSN | 1883-8030 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Fuji Technology Press Ltd. |
File Version | publisher |
DOI | 10.20965/jdr.2022.p0021 |
Web of Science KeyUT | 000748695600003 |
Related Url | isVersionOf https://doi.org/10.20965/jdr.2022.p0021 |
JaLCDOI | 10.18926/AMO/64370 |
---|---|
FullText URL | 77_1_105.pdf |
Author | Iwasaki, Yoshiaki| Higuchi, Chigusa| |
Abstract | The inactivated coronavirus disease 2019 vaccine CoronaVac has not been approved in Japan. Little information is available on cases in Japan in which an approved mRNA vaccine was administered as the initial (first or second) dose after two doses of CoronaVac. Furthermore, the safety and efficacy of this combination are not established. We here evaluated the safety and efficacy in a patient who showed an antibody response to an approved vaccine, mRNA-1273, after a previous vaccination with CoronaVac. The adverse events consisted of only mild local and systemic common reactions and were transient. In addition, a strong and persistent antibody response was observed. |
Keywords | coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 vaccine adverse events antibody response |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2023-02 |
Volume | volume77 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 105 |
End Page | 109 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 36849154 |
Web of Science KeyUT | 000953005500001 |
FullText URL | fulltext.pdf |
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Author | Nakahara, Momoko| Ekuni, Daisuke| Kataoka, Kota| Yokoi, Aya| Uchida-Fukuhara, Yoko| Fukuhara, Daiki| Kobayashi, Terumasa| Toyama, Naoki | Saho, Hikari| Islam, Md Monirul| Iwasaki, Yoshiaki| Morita, Manabu| |
Keywords | lifestyle dental health behavior oral health oral hygiene gingivitis behavioral sciences |
Published Date | 2021-01-05 |
Publication Title | International Journal of Environmental Research and Public Health |
Volume | volume18 |
Issue | issue1 |
Publisher | MDPI |
Start Page | 324 |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. |
File Version | publisher |
PubMed ID | 33466244 |
DOI | 10.3390/ijerph18010324 |
Web of Science KeyUT | 000606664400001 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph18010324 |
FullText URL | fulltext.pdf |
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Author | Afify, Said M.| Calle, Anna Sanchez| Hassan, Ghmkin| Kumon, Kazuki| Nawara, Hend M.| Zahra, Maram H.| Mansour, Hager M.| Khayrani, Apriliana Cahya| Alam, Md Jahangir| Du, Juan| Seno, Akimasa| Iwasaki, Yoshiaki| Seno, Masaharu| |
Keywords | Cancer models Cancer stem cells |
Published Date | 2020-03-17 |
Publication Title | British Journal of Cancer |
Volume | volume122 |
Issue | issue9 |
Publisher | Springer Nature |
Start Page | 1378 |
End Page | 1390 |
ISSN | 0007-0920 |
NCID | AA00574355 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Authors |
File Version | publisher |
PubMed ID | 32203212 |
DOI | 10.1038/s41416-020-0792-z |
Web of Science KeyUT | 000519841900001 |
Related Url | isVersionOf https://doi.org/10.1038/s41416-020-0792-z |
FullText URL | fulltext.pdf |
---|---|
Author | Saho, Hikari| Taniguchi-Tabata, Ayano| Ekuni, Daisuke| Yokoi, Aya| Kataoka, Kouta| Fukuhara, Daiki| Toyama, Naoki | Islam, Md Monirul| Sawada, Nanami| Nakashima, Yukiho| Nakahara, Momoko| Deguchi, Junya| Uchida-Fukuhara, Yoko| Yoneda, Toshiki| Iwasaki, Yoshiaki| Morita, Manabu| |
Keywords | secondhand smoke dental caries permanent dentition young adult |
Published Date | 2020-11-20 |
Publication Title | International Journal of Environmental Research and Public Health |
Volume | volume17 |
Issue | issue22 |
Publisher | MDPI |
Start Page | 8623 |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33233610 |
DOI | 10.3390/ijerph17228623 |
Web of Science KeyUT | 000594343500001 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph17228623 |
FullText URL | fulltext.pdf |
---|---|
Author | Fukuhara, Daiki| Ekuni, Daisuke| Kataoka, Kota| Taniguchi-Tabata, Ayano| Uchida-Fukuhara, Yoko| Toyama, Naoki | Yoneda, Toshiki| Sugiura, Yoshio| Islam, Monirul| Saho, Hikari| Iwasaki, Yoshiaki| Morita, Manabu| |
Published Date | 2020-07-23 |
Publication Title | PLoS ONE |
Volume | volume15 |
Issue | issue7 |
Publisher | Public Library of Science |
Start Page | e0236259 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Fukuhara et al. |
File Version | publisher |
PubMed ID | 32702010 |
DOI | 10.1371/journal.pone.0236259 |
Web of Science KeyUT | 000575913700064 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0236259 |
FullText URL | fulltext.pdf |
---|---|
Author | Uchida-Fukuhara, Yoko| Ekuni, Daisuke| Islam, Md Monirul| Kataoka, Kota| Taniguchi-Tabata, Ayano| Fukuhara, Daiki| Toyama, Naoki | Kobayashi, Terumasa| Fujimori, Kohei| Sawada, Nanami| Iwasaki, Yoshiaki| Morita, Manabu| |
Keywords | salivary microbiome sequence analysis young adult dental caries saliva oral health |
Published Date | 2020-05-25 |
Publication Title | International Journal of Environmental Research and Public Health |
Volume | volume17 |
Issue | issue10 |
Publisher | MDPI |
Start Page | 3713 |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32466124 |
DOI | 10.3390/ijerph17103713 |
Web of Science KeyUT | 000539300900370 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph17103713 |
FullText URL | fulltext.pdf |
---|---|
Author | Islam, Md Monirul| Ekuni, Daisuke| Toyama, Naoki | Taniguchi-Tabata, Ayano| Kataoka, Kota| Uchida-Fukuhara, Yoko| Fukuhara, Daiki| Saho, Hikari| Sawada, Nanami| Nakashima, Yukiho| Iwasaki, Yoshiaki| Morita, Manabu| |
Keywords | sleep quality sleep duration periodontal disease university students |
Published Date | 2020-04-27 |
Publication Title | International Journal of Environmental Research and Public Health |
Volume | volume17 |
Issue | issue9 |
Publisher | MDPI |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32349308 |
DOI | 10.3390/ijerph17093034 |
Web of Science KeyUT | 000535745400058 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph17093034 |
FullText URL | fulltext.pdf |
---|---|
Author | Islam, Md Monirul| Ekuni, Daisuke| Toyama, Naoki | Kobayashi, Terumasa| Fujimori, Kohei| Uchida, Yoko| Fukuhara, Daiki| Taniguchi-Tabata, Ayano| Kataoka, Kota| Iwasaki, Yoshiaki| Morita, Manabu| |
Keywords | salivary microbiome periodontal health status oral hygiene cohort study young adults |
Published Date | 2020-03-09 |
Publication Title | International Journal of Environmental Research and Public Health |
Volume | volume17 |
Issue | issue5 |
Publisher | MDPI |
Start Page | 1764 |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32182740 |
DOI | 10.3390/ijerph17051764 |
Web of Science KeyUT | 000522389200304 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph17051764 |
FullText URL | OL18_3_2756.pdf |
---|---|
Author | Seno, Akimasa| Murakami, Chikae| El‑Aarag, Bishoy| Iwasaki, Yoshiaki| Ohara, Toshiaki| Seno, Masaharu| |
Keywords | cancer stem cell conditioned medium mouse embryonic stem cells |
Published Date | 2019-09 |
Publication Title | Oncology Letters |
Volume | volume18 |
Issue | issue3 |
Publisher | Spandidos Publications |
Start Page | 2756 |
End Page | 2762 |
ISSN | 1792-1074 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Seno et al. |
File Version | publisher |
PubMed ID | 31452753 |
DOI | 10.3892/ol.2019.10614 |
Web of Science KeyUT | 000487675500075 |
Related Url | isVersionOf https://doi.org/10.3892/ol.2019.10614 |
FullText URL | JOC61_1_133.pdf |
---|---|
Author | Taniguchi-Tabata, Ayano| Ekuni, Daisuke| Azuma, Tetsuji| Yoneda, Toshiki| Yamane-Takeuchi, Mayu| Kataoka, Kota| Mizuno, Hirofumi| Miyai, Hisataka| Iwasaki, Yoshiaki| Morita, Manabu| |
Keywords | lactate dehydrogenase gingivitis; screening young adults cross-sectional study |
Published Date | 2019-03-28 |
Publication Title | Journal of Oral Science |
Volume | volume61 |
Issue | issue1 |
Publisher | Nihon University School of Dentistry |
Start Page | 133 |
End Page | 139 |
ISSN | 1343-4934 |
NCID | AA11208439 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 30814390 |
DOI | 10.2334/josnusd.18-0038 |
Web of Science KeyUT | 000462712900019 |
Related Url | isVersionOf https://doi.org/10.2334/josnusd.18-0038 |
FullText URL | ijerph16_5_00690.pdf |
---|---|
Author | Toyama, Naoki| Ekuni, Daisuke| Taniguchi-Tabata, Ayano| Kataoka, Kota| Yamane-Takeuchi, Mayu| Fujimori, Kohei| Kobayashi, Terumasa| Fukuhara, Daiki| Irie, Koichiro| Azuma, Tetsuji| Iwasaki, Yoshiaki| Morita, Manabu| |
Keywords | bruxism cohort study malocclusion underweight young adults |
Published Date | 2019-02-26 |
Publication Title | International Journal of Environmental Research and Public Health |
Volume | volume16 |
Issue | issue5 |
Publisher | MDPI |
Start Page | 690 |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 by the authors |
File Version | publisher |
PubMed ID | 30813621 |
DOI | 10.3390/ijerph16050690 |
Web of Science KeyUT | 000462664200015 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph16050690 |
JaLCDOI | 10.18926/AMO/53560 |
---|---|
FullText URL | 69_4_237.pdf |
Author | Nanba, Shintarou| Ikeda, Fusao| Fujioka, Shin-ichi| Araki, Yasuyuki| Takaguchi, Kouichi| Hashimoto, Noriaki| Seki, Hiroyuki| Takaki, Akinobu| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
Abstract | The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51オ), and 89オ of them obtained sustained virological response (SVR), while 69オ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence<80オ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2. |
Keywords | hepatitis C virus interferon genotype 2 response-guided therapy |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-08 |
Volume | volume69 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 237 |
End Page | 244 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 26289915 |
Web of Science KeyUT | 000365519100007 |
JaLCDOI | 10.18926/AMO/53520 |
---|---|
FullText URL | 69_3_137.pdf |
Author | Seki, Hiroyuki| Ikeda, Fusao| Nanba, Shintaro| Moritou, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Nakamura, Minoru| Yamamoto, Kazuhide| |
Abstract | A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. |
Keywords | primary biliary cirrhosis keratin 7 hepatic failure |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-06 |
Volume | volume69 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 137 |
End Page | 144 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 26101189 |
Web of Science KeyUT | 000356903000002 |
Author | Shoji, Bon| Ikeda, Fusao| Fujioka, Shin-ichi| Kobashi, Haruhiko| Yasunaka, Tetsuya| Miyake, Yasuhiro| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
---|---|
Published Date | 2010-11 |
Publication Title | Journal of Gastroenterology |
Volume | volume45 |
Issue | issue11 |
Content Type | Journal Article |
Author | Takeuchi, Yasuto| Ikeda, Fusao| Moritou, Yuki| Hagihara, Hiroaki| Yasunaka, Tetsuya| Kuwaki, Kenji| Miyake, Yasuhiro| Ohnishi, Hideki| Nakamura, Shinichiro| Shiraha, Hidenori| Takaki, Akinobu| Iwasaki, Yoshiaki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
---|---|
Published Date | 2013-03 |
Publication Title | Journal of Gastroenterology |
Volume | volume48 |
Issue | issue3 |
Content Type | Journal Article |
Author | Moritou, Yuki| Ikeda, Fusao| Takeuchi, Yasuto| Seki, Hiroyuki| Nanba, Shintaro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
---|---|
Published Date | 2014-02 |
Publication Title | Journal of Clinical Microbiology |
Volume | volume52 |
Issue | issue2 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/52898 |
---|---|
FullText URL | 68_5_291.pdf |
Author | Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide| |
Abstract | It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At>3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect. |
Keywords | interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2014-10 |
Volume | volume68 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 291 |
End Page | 302 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25338486 |
Web of Science KeyUT | 000343269300006 |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53129 |
JaLCDOI | 10.18926/AMO/52894 |
---|---|
FullText URL | 68_5_263.pdf |
Author | Namba, Shihoko| Miyake, Kayoko| Ikeda, Fusao| Hazama, Tomoko| Hitobe, Yu| Yamasaki, Noriko| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
Abstract | Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p=0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence. |
Keywords | chronic hepatitis C nursing support interferon therapy |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2014-10 |
Volume | volume68 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 263 |
End Page | 268 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25338482 |
Web of Science KeyUT | 000343269300002 |