| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamoto, Shogo| Shien, Tadahiko| Iwamoto, Takayuki| Kubo, Shinichiro| Yamamoto, Mari| Yamashita, Tetsumasa| Kuwahara, Chihiro| Ikeda, Masahiko| |
| Published Date | 2024-04-30 |
| Publication Title | Scientific Reports |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 9869 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38684839 |
| DOI | 10.1038/s41598-024-60101-x |
| Web of Science KeyUT | 001211286800006 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-024-60101-x |
| JaLCDOI | 10.18926/AMO/66676 |
|---|---|
| FullText URL | 78_1_089.pdf |
| Author | Toshima, Kei| Shien, Tadahiko| Nishimura, Midori Filiz| Suzuki, Yoko| Nakamoto, Shogo| Uno, Maya| Yoshioka, Ryo| Tsukioki, Takahiro| Takahashi, Yuko| Iwamoto, Takayuki| Iwatani, Tsuguo| Yanai, Hiroyuki| |
| Abstract | We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult to distinguish from metastasis. |
| Keywords | breast cancer ectopic breast cancer axillary lymph node |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 89 |
| End Page | 93 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419320 |
| Web of Science KeyUT | 001204421300001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujihara, Miwa| Shien, Tadahiko| Shien, Kazuhiko| Suzawa, Ken| Takeda, Tatsuaki| Zhu, Yidan| Mamori, Tomoka| Otani, Yusuke| Yoshioka, Ryo| Uno, Maya| Suzuki, Yoko| Abe, Yuko| Hatono, Minami| Tsukioki, Takahiro| Takahashi, Yuko| Kochi, Mariko| Iwamoto, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| Keywords | breast cancer YES1 T-DM1 dasatinib drug resistance |
| Published Date | 2021-11-26 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume22 |
| Issue | issue23 |
| Publisher | MDPI |
| Start Page | 12809 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34884609 |
| DOI | 10.3390/ijms222312809 |
| Web of Science KeyUT | 000735641400001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms222312809 |
| JaLCDOI | 10.18926/AMO/62394 |
|---|---|
| FullText URL | 75_4_431.pdf |
| Author | Kunitomi, Toshiki| Nasu, Junichirou| Minami, Daisuke| Iwamoto, Takayuki| Nishie, Hiroyuki| Saito, Shinya| Fujiwara, Toshiyoshi| Matsuoka, Junji| |
| Abstract | This study aimed to evaluate whether there are differences in the attitudes and practices of cancer pain manage-ment between medical oncologists and palliative care physicians. An online nationwide survey was used to collect responses from board-certified medical oncologists and palliative care physicians in Japan. The survey questionnaire comprised 30 questions. The differences in responses between medical oncologists and palliative care physicians were examined. Out of the 1,227 questionnaires sent, 522 (42.5%) were returned. After apply-ing the exclusion criteria, 445 questionnaires (medical oncologists: n = 283; palliative care physicians: n = 162) were retained for analysis. Among the questions about potential barriers to optimal cancer pain man-agement, both medical oncologists and palliative care physicians considered the reluctance of patients to take opioids due to fear of adverse effects as the greatest barrier. Significantly different ratings between medical oncologists and palliative care physicians were observed on 5 of the 8 questions in this area. Significantly differ-ent ratings were observed for all questions concerning pain specialists and their knowledge. For effective cancer pain management, it is important to account for differences in attitudes and practice between medical oncolo-gists and palliative care physicians. |
| Keywords | cancer pain management opioid medical oncologist palliative care physician barriers |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 431 |
| End Page | 437 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511609 |
| Web of Science KeyUT | 000697944600004 |
| NAID | 120007146037 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Otsuka, Yuki| Nakano, Yasuhiro| Omura, Daisuke| Iwamoto, Takayuki| Hayashi, Ruiko| Otsuka, Fumio| |
| Keywords | autonomous functioning thyroid nodule hyperthyroidism thyroid papillary cancer toxic multinodular goiter |
| Published Date | 2021-01-26 |
| Publication Title | Clinical Case Reports |
| Volume | volume9 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 1810 |
| End Page | 1811 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| DOI | 10.1002/ccr3.3843 |
| Web of Science KeyUT | 000611662800001 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.3843 |
| JaLCDOI | 10.18926/AMO/60799 |
|---|---|
| FullText URL | 74_5_401.pdf |
| Author | Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| |
| Abstract | Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC. |
| Keywords | differentiated thyroid carcinoma juvenile children |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 401 |
| End Page | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106695 |
| Web of Science KeyUT | 000581970100004 |
| NAID | 120006892925 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamoto, Takayuki| Kajiwara, Yukiko| Zhu, Yidan| Iha, Shigemichi| |
| Keywords | Biomarker chemotherapy breast cancer gene expression |
| Published Date | 2020-07 |
| Publication Title | Chinese Clinical Oncology |
| Volume | volume9 |
| Issue | issue3 |
| Publisher | AME |
| Start Page | 27 |
| ISSN | 2304-3865 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 32192349 |
| DOI | 10.21037/cco.2020.01.06 |
| Web of Science KeyUT | 000543350700005 |
| Related Url | isVersionOf 10.21037/cco.2020.01.06 |
| FullText URL | CCP_fulltext.pdf |
|---|---|
| Author | Tsukioki, Takahiro| Shien, Tadahiko| Tanaka, Takehiro| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| Keywords | Breast cancer Metformin Preoperative Tils CD8 PD-L1 |
| Published Date | 2020-06-12 |
| Publication Title | Cancer Chemotherapy and Pharmacology |
| Volume | volume86 volume86 |
| Issue | issue1 issue1 |
| Publisher | Springer |
| Start Page | 55 55 |
| End Page | 63 63 |
| ISSN | 0344-5704 |
| NCID | AA00598397 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©Author(s) |
| File Version | publisher |
| PubMed ID | 32533334 |
| DOI | 10.1007/s00280-020-04092-2 |
| Web of Science KeyUT | 000539841500002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00280-020-04092-2 |
| Author | Iwamoto, Takayuki| Hara, Fumikata| Uemura, Yukari| Mukai, Hirofumi| Watanabe, Toru| Ohashi, Yasuo| |
|---|---|
| Keywords | Chemotherapy-induced amenorrhea Taxane Taxane Breast cancer Guarantee-time bias Premenopause |
| Published Date | 2020-05-28 |
| Publication Title | Breast Cancer Research and Treatment |
| Volume | volume182 |
| Issue | issue2 |
| Publisher | Springer |
| Start Page | 325 |
| End Page | 332 |
| ISSN | 0167-6806 |
| NCID | AA10623184 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32462261 |
| DOI | 10.1007/s10549-020-05692-5 |
| Web of Science KeyUT | 000539434600002 |
| Related Url | isVersionOf https://doi.org/10.1007/s10549-020-05692-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamoto, Takayuki| Fujisawa, Tomomi| Shien, Tadahiko| Araki, Kazuhiro| Sakamaki, Kentaro| Sangai, Takafumi| Kikawa, Yuichiro| Takao, Shintaro| Nishimura, Reiki| Takahashi, Masato| Aihara, Tomohiko| Mukai, Hirofumi| aira, Naruto| |
| Keywords | Metastatic breast cancer Endocrine therapies Estrogen receptor-positive HER2-negative Resistance |
| Published Date | 2020-05-11 |
| Publication Title | Breast Cancer |
| Volume | volume27 |
| Issue | issue5 |
| Publisher | Springer |
| Start Page | 973 |
| End Page | 981 |
| ISSN | 13406868 |
| NCID | AA1103354X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32394413 |
| DOI | 10.1007/s12282-020-01095-y |
| Web of Science KeyUT | 000531780600002 |
| Related Url | isVersionOf https://doi.org/10.1007/s12282-020-01095-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Suzuki, Yoko| Taniguchi, Kohei| Hatono, Minami| Kajiwara, Yukiko| Abe, Yuko| Kawada, Kengo| Tsukioki, Takahiro| Kochi, Mariko| Nishiyama, Keiko| Iwamoto, Takayuki| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Tabata, Masahiro| Yanai, Hiroyuki| Doihara, Hiroyoshi| |
| Keywords | Radiation-induced angiosarcoma Radiotherapy Breast-conserving surgery Breast cancer Paclitaxel therapy Adjuvant therapy of angiosarcoma |
| Published Date | 2020-01-16 |
| Publication Title | Surgical Case Reports |
| Volume | volume6 |
| Issue | issue1 |
| Publisher | SpringerOpen |
| Start Page | 25 |
| ISSN | 2198-7793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 31950295 |
| DOI | 10.1186/s40792-020-0790-7 |
| Web of Science KeyUT | 000513920900001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40792-020-0790-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takahashi, Yuko| Iwamoto, Takayuki| Suzuki, Yoko| Kajiwara, Yukiko| Hatono, Minami| Tsukioki, Takahiro| Kawada, Kengo| Kochi, Mariko| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| Keywords | Gene expression Hormone receptor positive Residual tumor burden Targeted therapy Triple negative |
| Published Date | 2020-04 |
| Publication Title | Clinical Breast Cancer |
| Volume | volume20 |
| Issue | issue2 |
| Publisher | Elsevier |
| Start Page | 117 |
| End Page | 124 |
| ISSN | 1526-8209 |
| NCID | AA11694891 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31570267 |
| DOI | 10.1016/j.clbc.2019.07.001 |
| Web of Science KeyUT | 000529805200021 |
| Related Url | isVersionOf https://doi.org/10.1016/j.clbc.2019.07.001 |
| FullText URL | BreastCancer_24_4_593.pdf BreastCancer_24_4_593_tbl_fig.pdf |
|---|---|
| Author | Saiga, Miho| Taira, Naruto| Kimata, Yoshihiro| Watanabe, Satoko| Mukai, Yuko| Shimozuma, Kojiro| Mizoo, Taeko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| |
| Keywords | BREAST-Q Breast cancer Breast reconstruction Health-related quality of life Satisfaction |
| Published Date | 2017-03 |
| Publication Title | Breast Cancer |
| Volume | volume24 |
| Issue | issue2 |
| Publisher | Japanese Breast Cancer Society |
| Start Page | 288 |
| End Page | 298 |
| ISSN | 1340-6868 |
| NCID | AA1103354X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 27179527 |
| DOI | 10.1007/s12282-016-0703-6 |
| Web of Science KeyUT | 000395524900012 |
| Related Url | isVerionOf https://doi.org/10.1007/s12282-016-0703-6 |
| JaLCDOI | 10.18926/AMO/54607 |
|---|---|
| FullText URL | 70_5_425.pdf |
| Author | Tamura, Tomoki| Hirata, Taizo| Tabata, Masahiro| Hinotsu, Shiro| Hamada, Akinobu| Motoki, Takayuki| Iwamoto, Takayuki| Mizoo, Taeko| Nogami, Tomohiro| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| |
| Abstract | Docetaxel is a standard treatment for patients with advanced or recurrent breast cancer. The recommended dose is 60 to 100 mg/m2. Previous study have shown that the tumor response rates of patients who received docetaxel monotherapy at doses of 60, 75, and 100 mg/m2 were 22.1% , 23.3% , and 36.0% , respectively, and there was a significant relationship between the dose and response. In Europe and the United States, docetaxel is approved at a dose of 100 mg/m2, and Japanese guidelines also recommend a dose of 100 mg/m2. However, the approved dose in Japan is up to 75 mg/m2. We have launched a phase I trial evaluating 100 mg/m2 docetaxel in patients with advanced or relapsed breast cancer. The major eligibility criteria are as follows: age ≥20 years, pathologically diagnosed breast cancer, recurrent or advanced breast cancer, a good performance status, and HER2 [human epidermal growth factor receptor 2] negative. The primary endpoint is demonstrated safety of 100 mg/m2 docetaxel. This study will clarify whether 100mg/m2 docetaxel can be administrated safely in Japanese patients with advanced or recurrent breast cancer. |
| Keywords | breast cancer phase I trial docetaxel |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 425 |
| End Page | 427 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777441 |
| Web of Science KeyUT | 000388098700018 |
| JaLCDOI | 10.18926/AMO/53907 |
|---|---|
| FullText URL | 69_6_333.pdf |
| Author | Ito, Maiko| Shien, Tadahiko| Kaji, Mitsumasa| Mizoo, Taeko| Iwamoto, Takayuki| Nogami, Tomohiro| Motoki, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Miyoshi, Shinichiro| |
| Abstract | We evaluated the usefulness of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations to predict the pathological features in primary breast cancer. In particular, we evaluated the correlation between the maximum standardized uptake values (SUVmax) obtained by 18F-FDG PET/CT and the Ki67 expression in estrogen receptor (ER)-positive invasive ductal carcinoma (IDC). Primary IDC patients operated between March 2009 and July 2013 at Okayama University Hospital were enrolled. We evaluated the correlations between the SUVmax and age, postoperative pT, histological grade, lymph vascular invasion, status of hormone receptor, human epidermal growth factor receptor 2 (HER2), Ki67 expression and node status. The Ki67 expression was classified as high (>14%) versus low (<14%). We enrolled 138 patients with IDC. Their median SUVmax was 3.85 (range:0-52.57). In a univariate analysis, the SUVmax was significantly related to age, pT, histological grade, lymphovascular invasion, hormone receptor status, HER2 status, node status and Ki67. In the 113 patients with ER-positive IDC, there was a significant correlation between Ki67 and SUVmax (p=0.0030). The preoperative 18F-FDG PET/CT results of IDC patients had significant relationships with pathological status parameters. The determination of the preoperative SUVmax might help classify Luminal A and Luminal B patients among luminal-type breast cancer patients. |
| Keywords | breast cancer invasive ductal carcinoma 18F-fluorodeoxyglucose positron emission tomography/computed tomography maximum standardized uptake values clinicopathological features |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-12 |
| Volume | volume69 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 333 |
| End Page | 338 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26690243 |
| Web of Science KeyUT | 000368434500002 |
| JaLCDOI | 10.18926/AMO/53675 |
|---|---|
| FullText URL | 69_5_291.pdf |
| Author | Sugiu, Kumi| Iwamoto, Takayuki| Kelly, Catherine M.| Watanabe, Naoki| Motoki, Takayuki| Itoh, Mitsuya| Ohtani, Shoichiro| Higaki, Kenji| Imada, Takako| Yuasa, Takeshi| Omori, Masako| Sonobe, Hiroshi| Fujiwara, Toshiyoshi| Matsuoka, Junji| |
| Abstract | Although in the neoadjuvant setting for estrogen receptor (ER)-positive breast cancers, chemotherapy or hormone therapy alone does not result in satisfactory tumor response, it is unknown whether concurrent chemo-endocrine therapy is superior to chemotherapy alone in clinical outcomes. We conducted a randomized phase II trial to test the responses of ER-positive patients to concurrent administration of chemo-endocrine therapy in the neoadjuvant setting. Women with stage II-III, ER-positive, invasive breast cancer (n=28) received paclitaxel followed by fluorouracil, epirubicin, cyclophosphamide (T-FEC) and were randomized to receive concurrent chemo-endocrine therapy consisting of goserelin administered subcutaneously for premenopausal women or an aromatase inhibitor for postmenopausal women. The primary endpoint was the pathological complete response (pCR) rate after neoadjuvant therapy. Twenty-eight patients were randomized. There were no significant differences in pCR rate between the concurrent group (12.5%;2/16) and the chemotherapy alone group (8.3%;1/12). Tumor size after therapy was significantly reduced in the concurrent therapy group (p=0.035), but not in the chemotherapy-alone group (p=0.622). Neoadjuvant chemotherapy with concurrent hormone therapy provided no significant improvement in pCR rate in ER-positive breast cancers. These preliminary results should be followed up by further studies. |
| Keywords | breast cancer neoadjuvant chemotherapy concurrent hormone therapy estrogen receptor positive tumor response |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-10 |
| Volume | volume69 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 291 |
| End Page | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26490026 |
| Web of Science KeyUT | 000365519600005 |
