ID | 66945 |
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Author |
Nakashima, Mitsutaka
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyoshi, Toru
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
Tanakaya, Machiko
Department of Cardiovascular Medicine, National Hospital Organization Iwakuni Clinical Center
Saito, Takaaki
Department of Cardiovascular Medicine, National Hospital Organization Iwakuni Clinical Center
Katayama, Yusuke
Department of Cardiovascular Medicine, National Hospital Organization Iwakuni Clinical Center
Sakuragi, Satoru
Department of Cardiovascular Medicine, National Hospital Organization Iwakuni Clinical Center
Takaya, Yoichi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
Ito, Hiroshi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Abstract | The fibrosis-4 index (FIB4), a liver fibrosis maker, has been shown to be associated with the prognosis in patients with severe isolated tricuspid regurgitation (TR). Recent study showed that the fibrosis-5 index (FIB5), which was calculated by albumin, alkaline phosphatase, aspartate transaminase, alanine aminotransferase and platelet count, had better prognostic value than FIB4 in patients with heart failure. The aim of this study was to evaluate the usefulness of FIB5 index for predicting prognosis in patients with severe isolated TR and compare the prognostic value between the FIB4 and the FIB5 in those patients. This was a dual-center, retrospective study. 113 consecutive outpatients with severe isolated TR (mean age, 65.8 years; 47.8% male) were analyzed. Major adverse cardiovascular events (MACEs) were defined as the composite of cardiovascular death, hospitalization for heart failure, myocardial infarction, and stroke. During a median follow-up of 3.0 years, 41 MACEs occurred. Patients with MACEs had a lower the FIB5 than patients without MACEs. The multivariate Cox analysis revealed that the FIB5 < -4.30 was significantly associated with higher incidence of MACEs after adjusted by confounding factors. Receiver-operating characteristic curve analyses showed that prognostic values did not differ between the FIB5 and the FIB4 in whole patients and in patients aged ≥ 70 years; while, in patients aged < 70 years, the FIB5 had better prognostic value than the FIB4. The FIB5 may be a useful predictor of MACEs in patients with severe isolated TR.
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Keywords | Liver disorder
Fibrosis-4 index
Fibrosis-5 index
Isolated tricuspid regurgitation
Major adverse cardiac events
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Note | The version of record of this article, first published in Heart and Vessels, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00380-023-02268-3
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Published Date | 2023-04-23
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Publication Title |
Heart and Vessels
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Volume | volume38
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Issue | issue9
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Publisher | Springer Science and Business Media LLC
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Start Page | 1181
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End Page | 1189
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ISSN | 0910-8327
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NCID | AA10452161
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © The Author(s) 2023
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.1007/s00380-023-02268-3
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License | http://creativecommons.org/licenses/by/4.0/
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Citation | Nakashima, M., Miyoshi, T., Tanakaya, M. et al. Prognostic value of the liver fibrosis marker fibrosis-5 index in patients with severe isolated tricuspid regurgitation: comparison with fibrosis-4 index. Heart Vessels 38, 1181–1189 (2023). https://doi.org/10.1007/s00380-023-02268-3
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Funder Name |
Okayama University
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