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Kin, Ittetsu Department of Neurological Surgery, Okayama University Graduate School of Medicine
Sasaki, Tatsuya Department of Neurological Surgery, Okayama University Graduate School of Medicine
Yasuhara, Takao Department of Neurological Surgery, Okayama University Graduate School of Medicine ORCID Kaken ID publons researchmap
Kameda, Masahiro Department of Neurological Surgery, Okayama University Graduate School of Medicine Kaken ID researchmap
Agari, Takashi Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital Kaken ID publons
Okazaki, Mihoko Department of Neurological Surgery, Okayama University Graduate School of Medicine
Hosomoto, Kakeru Department of Neurological Surgery, Okayama University Graduate School of Medicine
Okazaki, Yosuke Department of Neurological Surgery, Okayama University Graduate School of Medicine
Yabuno, Satoru Department of Neurological Surgery, Okayama University Graduate School of Medicine
Kawauchi, Satoshi Department of Neurological Surgery, Okayama University Graduate School of Medicine
Kuwahara, Ken Department of Neurological Surgery, Okayama University Graduate School of Medicine
Morimoto, Jun Department of Neurological Surgery, Okayama University Graduate School of Medicine
Kin, Kyohei Department of Neurological Surgery, Okayama University Graduate School of Medicine ORCID publons
Umakoshi, Michiari Department of Neurological Surgery, Okayama University Graduate School of Medicine
Tomita, Yousuke Department of Neurological Surgery, Okayama University Graduate School of Medicine
Tajiri, Naoki Department of Neurophysiology and Brain Science and Medical School, Graduate School of Medical Sciences and Medical School, Nagoya City University
Borlongan, Cesario, V Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd.
Date, Isao Department of Neurological Surgery, Okayama University Graduate School of Medicine ORCID Kaken ID publons researchmap
Abstract
Background: The major surgical treatment for Parkinson's disease (PD) is deep brain stimulation (DBS), but a less invasive treatment is desired. Vagus nerve stimulation (VNS) is a relatively safe treatment without cerebral invasiveness. In this study, we developed a wireless controllable electrical stimulator to examine the efficacy of VNS on PD model rats. Methods: Adult female Sprague-Dawley rats underwent placement of a cuff-type electrode and stimulator on the vagus nerve. Following which, 6-hydroxydopamine (6-OHDA) was administered into the left striatum to prepare a PD model. VNS was started immediately after 6-OHDA administration and continued for 14 days. We evaluated the therapeutic effects of VNS with behavioral and immunohistochemical outcome assays under different stimulation intensity (0.1, 0.25, 0.5 and 1 mA). Results: VNS with 0.25-0.5 mA intensity remarkably improved behavioral impairment, preserved dopamine neurons, reduced inflammatory glial cells, and increased noradrenergic neurons. On the other hand, VNS with 0.1 mA and 1 mA intensity did not display significant therapeutic efficacy. Conclusions: VNS with 0.25-0.5 mA intensity has anti-inflammatory and neuroprotective effects on PD model rats induced by 6-OHDA administration. In addition, we were able to confirm the practicality and effectiveness of the new experimental device.
Keywords
anti-inflammation
less invasive therapy
new experimental device
Parkinson's disease
vagus nerve stimulation
Published Date
2021-07-07
Publication Title
Biomedicines
Volume
volume9
Issue
issue7
Publisher
MDPI
Start Page
789
ISSN
2227-9059
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2021 by the authors.
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publisher
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.3390/biomedicines9070789
License
https://creativecommons.org/licenses/by/4.0/
Funder Name
Ministry of Health, Labour and Welfare, Japan
助成番号
09156274
24592129