| Author | Kikuchi, Hiroshi| Shiozawa, Nobuyoshi| Takata, Shingo| Ashida, Kozo| Mitsunobu, Fumihiro| |
|---|---|
| Published Date | 2013-12-12 |
| Publication Title | International Journal of Chronic Obstructive Pulmonary Disease |
| Volume | volume9 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/15096 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 3.気道炎症反応との関連 |
| FullText URL | 067_099_106.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | The degree and characteristic of airway inflammation were evaluated by the proportions of bronchoalveolar lavage (BAL) cells. Clinical asthma types such as Ia. simple bronchoconstriction, Ib. bronchoconstriction + hypersecretion, and Ⅱ. bronchiolar obstruction correlate with airway inflammation. The increased proportion BAL neutrophils is characteristic of type Ⅱ asthma, and increase in BAL eosinophil count is often observed in type Ib asthma. Bronchial hyperresponsiveness also correlates with airway inflammation. Action of spa therapy has been speculated to be related to airway inflammation, since the therapy has no action inhibiting IgE-mediated allergic reaction. In fact, spa therapy is more effective in patients with type Ib and type Ⅱ than in those with type Ia showing slight degree of airway inflammation. Bronchial hyperresponsiveness is also improved by spa therapy. From a point of view, the direct action of spa therapy may be to clean airways and improve damaged mucous membrane of the airways, leading to suppression of airway inflammation. |
| Keywords | Spa therapy (温泉療法) Airway inflammation (気道炎症反応) BAL eosinophilia (BAL好酸球増多) BAL neutrophilia (BAL好中球増多) Bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 99 |
| End Page | 106 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307894 |
| JaLCDOI | 10.18926/15094 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 2.内分泌･自律神経系および心因的要素に対する効果 |
| FullText URL | 067_092_098.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Saito, Katsuyoshi| |
| Abstract | Actions of spa therapy on endocrine-autonomic nerve system and psychological factors were analyzed in patients with bronchial asthma. In endocrine function, serum levels of cortisol and ACTH tended to increase after spa therapy. In autonomic nerve system, decrease in concentrations of serum adrenalin and noradrenalin was observed after spa therapy, and the difference between the initial levels before spa therapy and the levels after the therapy was significant in serum levels of adrenalin. However, serum levels of substance P and Bradykinin were not affected by spa therapy. To evaluate the action of spa therapy on mental condition in patients with asthma, four kinds of psychological tests, CMI, SDS, CAl and SD, were carried out. Improvement of mental disorders in patients with asthma is observed after spa therapy in all psychological tests. These results suggest that spa therapy acts effectively on endocrine-autonomic nerve system and improve psychological conditions. |
| Keywords | Bronchial asthma (気管支喘息) Spa therapy (温泉療法) Endocrine-autonomic nerve system (内分泌・自律神経系) Psychological disorders (心的要素) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 92 |
| End Page | 98 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307879 |
| JaLCDOI | 10.18926/15093 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 1.温泉療法の評価方法との関連 |
| FullText URL | 067_085_091.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Action mechanisms of complex spa therapy (swimming training in a hot spring pool, inhalation with iodine salt solution, and fango therapy) were studied in relation to patient age, clinical asthma type, and airway inflammation. Actions of spa therapy were observed by two clinical effects : direct and indirect effects. Improvement of subjective symptoms, ventilatory function, and bronchial hyperresponsiveness was observed as direct effects of spa therapy, and improvement of suppressed function of adrenocortical glands as indirect effects of the therapy. The clinical effects of spa therapy were higher in patients over the age of 40. Regarding clinical asthma type, the effects were larger in patients with type Ib and type II asthma than in those with type Ia. The efficacy of spa therapy was closely related with airway inflammation in patients with type Ib and type II asthma. |
| Keywords | complex spa therapy (複合温泉療法) clinical asthma type (臨床病型) ventilatory function (換気機能) bronchial hyperresponsiveness (気道過敏性) adrenocortical glands (副腎皮質) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 85 |
| End Page | 91 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307192 |
| JaLCDOI | 10.18926/15092 |
|---|---|
| Title Alternative | Spa therapy and drug therapy in patients with bronchial asthma |
| FullText URL | 067_107_114.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kouzou| Yokota, Satoshi| Takeuchi, Kazuaki| Nawa, Yuichiro| |
| Abstract | 気管支喘息は,その臨床病態より,Ia.単純性気管支攣縮型,Ib.気管支痙攣縮+過分泌型,Ⅱ.細気管支閉塞型の3つの基本病型に分けることができる｡また,発症病態からは,アトピー型と非アトピー型に分けられる｡気管支喘息に対する温泉療法や薬物療法の際には,これらの臨床病態や発症病態を十分把握した上で最も適切な治療法を選ぶ必要がある｡気管支喘息に対する薬物療法では,気管支拡張薬,去痰薬,抗アレルギー薬,副腎皮質ホルモンなどがその主たるものであるが,特に薬物療法では気管支拡張作用と抗炎症作用が重要である｡一方,温泉療法では,気道の浄化作用や気管支粘膜の正常化作用などが得られ,臨床病型では,過分泌型や細気管支閉塞型に対してより効果的である｡また,発症病態からすれば,アトピー型ではヒスタミンとロイコトリエンが,非アトピー型ではロイコトリエンがより優勢な化学伝達物質であり,このような発症病態を十分把握した上で,適切な抗アレルギー薬を選ぶ必要が ある｡ |
| Keywords | 気管支喘息 (bronchial asthma) 臨床病型 (clinicaI classification) アトピー型 (atopic asthma) 温泉療法 (spa therapy) 薬物療法 (drug therapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 107 |
| End Page | 114 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307684 |
| JaLCDOI | 10.18926/15091 |
|---|---|
| Title Alternative | Ⅱ型喘息(細気管支閉塞型)と気管支肺胞洗浄液の好中球数 |
| FullText URL | 067_079_084.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Bronchial asthma is classified into three types ; type Ia (Ia-1 and Ia-2), type Ib, and type Ⅱ, by clinical symptoms (clinical diagnosis). Asthma is also classified by clinical findings and examinations (score diagnosis). Both classification systems show that markedly increased proportion of BAL neutrophils and marked decrease in % V25 value are characteristic of type Ⅱ, bronchiolar obstruction, asthma. However, there are some type Ⅱ asthma patients without BAL neutrophilia. In these patients, age is higher compared to those with BAL enutrophlia. Decrease in FEV1.0% value and decrease in the proportion of BAL lympocytes and serum IgG level, are not so remarkable as decrease in those with BAL neutrophilia. It has been suggested that type Ⅱ asthma with BAL neutrophilia correlates with suppression of humoral and cellular immunity, and same type of astma without BAL neutrophilia is in part caused by aging. |
| Keywords | Asthma classification (喘息分類) BAL lymphocytes (BALリンパ球) BAL neutrophils (BAL好中球) % V25 value Ⅱ型喘息 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 79 |
| End Page | 84 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307924 |
| JaLCDOI | 10.18926/15088 |
|---|---|
| Title Alternative | サーモグラフィーによる体表面温度の測定 |
| FullText URL | 067_063_070.pdf |
| Author | Hosaki, Yasuhiro| Nawa, Yuichiro| Takeuchi, Kazuaki| Tsugeno, Hirofumi| Ashida, Kozo| Yokota, Satoshi| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Body Surface Temperature was observed by thermography. The surface temperature of a healthy person's lower limbs, after being cooled in a water bath, increased in parallel with time. Patients with Diabetes Mellitus had different patterns in the rate of increase of the surface temperature. After cold loading, one patient had a 99% recovery ratio of surface temperature, the same level as healthy volunteers (83%, and 88%), as calculated by a picture processing program with the computerized thermotracer. However, the recovery ratio of other patients was poorer, ranging from 56% to under 6% recovery. This measurement of elevation of body temperature is useful for the estimation of peripheral blood flow in patients with lower limbcirculation failure. |
| Keywords | Thermography (サーモグラフィー) Diabetes Mellitus (糖尿病) Peripheral Circulation (末梢循環) Cold Loading (冷水負荷) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 63 |
| End Page | 70 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307566 |
| JaLCDOI | 10.18926/15087 |
|---|---|
| Title Alternative | 気管支喘息症例に対する鼻腔内ステロイド療法 |
| FullText URL | 067_057_062.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Bronchial asthma is often accompanied with allergic rhinitis or chronic sinusitis. Mucosal abnormalities of sinonasal cavity may influence lower respiratory responses in patients with asthma. We experienced a case of 72-year-old woman with asthma, who had dyspnea on exertion and a large volume of expectoration of more than 100mℓ a day. Furthermore she had nasal symptoms (nasal obstruction and rhinorrea) with prominent post-nasal discharge. Computed tomography (CT) scans of sinonasal cavity revealed marked thickness of nasal mucosa. Although her asthma symptoms such as wheezing and dyspnea improved by administration of bronchodialators, antiallergic agent, and beclomethason di isocyanate (BDI) accompanied with spa therapy after admission, the volume of expectoration revealed no decrease and her peak expiratory flow (PEF) didn't increase. The volume of expectoration and the PEF showed marked improvement after starting of intranasal glucocorticoid therapy. It is suggested from her clinical course that treatment with intranasal glucocorticoids is very important in asthmatic patients with mucosal abnormalities of sinonasal cavity. |
| Keywords | bronchial asthma (気管支喘息) rhinitis (鼻炎) intranasal steroid therapy (鼻腔内吸入ステロイド療法) expectoration (喀痰排出) peak expiratory flow (ピークフロー) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307814 |
| JaLCDOI | 10.18926/15008 |
|---|---|
| Title Alternative | 中高年発症型喘息患者におけるIgE系アレルギー反応の加令による変化 |
| FullText URL | 067_050_056.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Age-related changes in IgE-mediated allergic reaction were examined in patients with late onset asthma, whose asthma occured over the age at onset of 40. 1. The number of patients with a high serum IgE level over 3001U/mℓ was larger in those between the ages at onset of 40 and 49 and over age at onset 60 than in those between the ages at onset 50 and 59. 2. A positive RAST score to Hdm and cockroach allergens was more frequently found in patients between 40 and 49 and over age 60 at onset compared to those between 50 and 59 at onset. In contrast, the number of patients with a positive RAST to Candida was larger in those between 50 and 59 at onset than in those of between 40 and 49 and over 60 at onset. 3. Severe asthma was more frequently and slight asthma was less frequently observed in patients between 50 and 59 at onset than in those of the other age at onset groups. These results suggest that IgE-mediated allergic reaction in patients between the ages at onset of 50 and 59 is different from that in those with early onset asthma, and that the reaction in patients between the ages at onset 40 and 49 and over 60 resembles to the reaction in those with early onset asthma. |
| Keywords | IgE RAST 吸入抗原 (inhalant Allergen) 気管支喘息 (Bronchial asthma) 加令 (aging) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 50 |
| End Page | 56 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307989 |
| JaLCDOI | 10.18926/15007 |
|---|---|
| Title Alternative | 温泉療法による気管支喘息患者の心理的障害の改善 |
| FullText URL | 067_043_049.pdf |
| Author | Yokota, Satoshi| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine| |
| Abstract | To evaluate improvement of mental disorders by spa therapy for 1-2 months, three kinds of psychological examinations, CMI (Cornel Medical Index), SDS (Selfrating Depression Scale) and CAI (Comprehensive Asthma Inventory) tests, were performed in 37 patients with asthma before and after spa therapy. 1. In CMI test, the scores of physical symptoms, respiratory symptoms, and CIJ symptoms significantly decreased after spa therapy. The score of psychical symptoms tended to decrease after the therapy, however, this was not significant. 2. The mean score of the subjects over 40 points in SDS test significantly decreased from 45.7 points before spa therapy to 37.5 after the therapy. 3. Mental disorders evaluated by various categories in CAI test were significantly improved after spa therapy. The average score in CAI test significantly decreased from 37.1 to 27.8 after the therapy. These results demonstrate that psychological disorders in patients with asthma are improved by spa therapy. |
| Keywords | 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 心理テスト（CMI, SDS, CAI) (CMI test, SDS test, CAI test) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 43 |
| End Page | 49 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307273 |
| JaLCDOI | 10.18926/15006 |
|---|---|
| Title Alternative | 気管支喘息におけるエゴマ油と白血球のロイコトリエンB4,C4合成 |
| FullText URL | 067_035_042.pdf |
| Author | Ashida, Kozo| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tsugeno, Hirofumi| Tanizaki, Yoshiro| Yamamoto, Junko| Tsuji, Takao| |
| Abstract | In recent years, it has been noted that there is a close correlation between leukotrienes and late asthmatic reaction (LAR). In this study, effects of dietary supplementation with perilla seed oil rich in alpha-linolenic acid, which is speculated to affect the generation of leukotrienes through metabolism of arachidonic acid (AA), were evaluated in 6 patients with asthma. The symptoms and ventilatory function were improved after 2-week dietary supplementation with perilla seed oil. The generation of LTB4 and LTC4 by peripheral leucocytes stimulated with Ca ionophore A23187 was significantly suppressed by the dietary supplementation (LTB4 and LTC4 ; p<0.05). Regarding the composition of fatty acids in serum phospholipids, the concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and AA tended to increase after the supplementation, accompanied with an increase in the ratio of EPA to AA. These results suggest that dietary supplementation with perilla seed oil brings beneficial effects in the treatment of asthma. |
| Keywords | n-3系脂肪酸 (n-3 fatty acids) 気管支喘息 (bronchial asthma) アラキドン酸 (arachidonic acid) LTB4 LTC4 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 35 |
| End Page | 42 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307804 |
| JaLCDOI | 10.18926/15002 |
|---|---|
| Title Alternative | Ia型(単純気管支れん縮型)喘息における気道過敏性について…年齢および気管支肺胞洗浄液中の細胞成分との関連について |
| FullText URL | 067_028_034.pdf |
| Author | Ashida, Kozo| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Bronchial hyperresponsiveness was examined in relation to age, ventilatory function, and the proportion of bronchoalveolar lavage (BAL) cells in 39 patients with type Ia asthma (simple bronchoconstriction) (25 with type Ia-1 and 14 with type Ia-2), classified by clinical symptoms. 1. The proportion of BAL eosinophils was significantly higher in type Ia-2 than that in type Ia-1 asthma patients. 2. Bronchial reactivity to methacholine was not different between type Ia-1 and type Ia-2 asthma patients. 3. Bronchial hyperreactivity tended to decrease as patient age was higher in both types of asthma. Neither ventilatory function (FEV1.0%) nor the proportions of BAL lymphocytes and neutrophils was not correlated with bronchial hyperresponsiveness in both types of asthma. 4. Bronchial reactivity to methacholine more dereased with the increase in the proportion of BAL eosinophils in both type Ia-1 and Ia-2 asthma patients. The results show that bronchial hyperresponsiveness in patients with type Ia asthma is correlated to patients age and the proportion of BAL eosinophils. |
| Keywords | Bronchial hyperresponsiveness Type Ia asthma Patient age BAL eosinophiIs |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 28 |
| End Page | 34 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307134 |
| JaLCDOI | 10.18926/15001 |
|---|---|
| Title Alternative | アトピー型および非アトピー型気管支喘息の発作発症機序の差異について･･･ロイコトリエンC4の役割について |
| FullText URL | 067_021_027.pdf |
| Author | Ashida, Kozo| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tsugeno, Hirofumi| Tanizaki, Yoshiro| |
| Abstract | Concentrations of main bronchoconstricting chemical mediators, histamine and leukotriene C4 (LTC4), were measured in bronchoalveolar lavage (BAL) fluid, and when cells (peripheral leukocytes and BAL cells) were stimulated by Ca ionophore A23187, in 7 atopic and 7 nonatopic asthma patients. 1. The proportion of basophilic cells was significantly larger in atopic than in nonatopic asthma (p<0.05), however no significant difference was present in the other BAL cells between the two asthma types. 2. Concentration of histamine in BAL fluid was significantly higher in atopic than that in nonatopic asthma, however, difference in that of LTC4 was not found between them. 4. The release of LTC 4 from BAL cells was higher in nonatopic than that in atopic asthma, but this was not significant. In contrast, the release of histamine was significantly higher in atopic compared to that in nonatopic asthma (p<0.001) when the cells were stimulated by Ca ionophore A23187. These results suggest that both histamine and LTC4 participate in the onset mechanism of atopic asthma, and only LTC4 in that of nonatopic asthma. |
| Keywords | Histamine LTC4 atopic nonatopic BAL cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 21 |
| End Page | 27 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307446 |
| JaLCDOI | 10.18926/15000 |
|---|---|
| Title Alternative | Ⅱ型(細気管支閉塞)喘息と閉塞性細気管支炎における細気管支領域の炎症反応の差 |
| FullText URL | 067_014_020.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine| |
| Abstract | Ventilatory function and inflammatory cells in airways were compared between patients with type Ⅱ (bronchiolar obstruction) asthma and those with obstructive bronchiolitis. 1. Age and age at onset were higher in patients with type Ⅱ asthma than in those with obstructive bronchiolitis. IgE-mediated allergic reaction was observed in patients with type Ⅱ asthma, but not in those with obstructive bronchiolitis. 2. In ventilatory function tests, all ventilatory parameters examined were lower in patients with type Ⅱ asthma compared to those with obstructive bronchiolitis, and the differences were significant in FEV1.0% (p<0.001), % MMF (p<0.02), and V50 (p<0.01). 3. The proportion of BAL neutrophils was very high in type Ⅱ asthma (55.7%) and obstructive bronchiolitis (74.4%), however, this was not significant. 4. Absolute numbers/BAL fluid of total cells, BAL macrophages and BAL neutrophils were significantly higher in patients with obstructive bronchiolitis than in those with type Ⅱ asthma. 5. The results on absolute number/mℓ of BAL cells demonstrated that number of BAL neutrophils markedly larger in patients with obstructive bronchiolitis compared to those with type Ⅱ asthma. These results show that high proportion of BAL neutrophils was observed in the two respiratory diseases, however, the degree of inflammation in airways was markedly greater in obstructive bronchiolitis. |
| Keywords | Ⅱ型喘息 (Type Ⅱasthma) 閉塞性細気管支炎 (Obstructive bronchiolitis) 換気機能 (Ventilatory function) BAL好中球 (BAL neutrophiIs) IgE系反応 (IgE-mediated allergy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 14 |
| End Page | 20 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307471 |
| JaLCDOI | 10.18926/14999 |
|---|---|
| Title Alternative | 肺活量(FVC)低値を示す気管支喘息の臨床的特徴 |
| FullText URL | 067_008_013.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Clinical features of asthma patients with a low % FVC (<75%) were studied in relation to clinical asthma type and disease severity. 1. The value of % FVC was not related to patient age. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type Ⅱ asthma (bronchiolar obstruction) than in those with type Ia-1 and type Ia-2 (simple bronchoconstriction) (p<0.001). 3. % FVC value significantly correlated with disease severity. The value in the subjects tended to decrease as their asthma conditions were more severe. 4. The % FVC value in the subjects was improved after treatment (complex spa therapy). These results demonstrate that a significant correlation is present between low % FVC and disease severity in asthma patients with a low % FVC. |
| Keywords | % FVC低値 (Low % FVC) 気管支喘息 (Bronchial asthma) 臨床病型 (Clinical asthma type) 重症度 (asthma severity) 温泉療法 (Spa therapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 8 |
| End Page | 13 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308511 |
| JaLCDOI | 10.18926/14998 |
|---|---|
| Title Alternative | BAL液中好中球増加をともなわないⅡ型喘息について |
| FullText URL | 067_001_007.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Tsuji, Takao| |
| Abstract | Clinical features of asthma patients with bronchiolar obstruction (type Ⅱ asthma) were studied in relation to the proportion of neutrophils in bronchoalveolar lavage (BAL) fluid. Of 13 subjects studied, 7 were accompanied with BAL neutrophilia (53.5%) (BALn(+)) and 6 were without BAL neutrophilia (3.5%) (BALn(-)). 1. The mean age was higher in BALn(-) (66.0 years) than in BALn(+) patients (55.0 years). 2. Bronchial reactivity to methacholine was slightly higher in BALn(-) patients than in those with BALn(+). 3. The value of FEV1.0% was significantly lower in BALn(+) patints than in those with BALn(-) (p<0.01). 4. The proportion of BAL lymphocytes was signicantly more decreased in BALn(+) patients compared to the proportion in those with BALn(-) (p<0.001). 5. the values of serum IgG, IgA, and IgM were not significantly different between BALn(+) and BALn(-) patients, however, the value of IgG was more decreased in BALn(+) patients than in those with BALn(-). These results suggest that two kinds of type Ⅱ asthma ; one is with BAL neutrophilia related to suppressed immunity, and another is without BAL neutrophilia in part due to aging. |
| Keywords | 気管支喘息 (Bronchial asthma) 細気管支閉塞 (Bronchiolar obstruction) BAL好中球 (BAL neutrophilia) 免疫能低下 (Suppressed immunity) 加齢 (Aging) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308171 |
| JaLCDOI | 10.18926/14994 |
|---|---|
| Title Alternative | Three cases of rheumatoid arthritis with biliary tract cancer |
| FullText URL | 068_107_114.pdf |
| Author | Iwagaki, Naofumi| Tsugeno, Hirofumi| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Okamoto, Makoto| Tanizaki, Yoshiro| |
| Abstract | 一般的に,慢性関節リウマチには悪性腫瘍の合併は少ないと言われている｡特に,消化器系あるいは胆道系悪性腫瘍を合併したという報告は極めて少ない｡我々は慢性関節リウマチの経過中,胆道系悪性腫瘍を合併した3例を経験した｡3症例はそれぞれ胆嚢癌,肝内胆管癌,乳頭部癌を合併していた｡非常に稀な症例であり,文献的考案を含め報告する｡ |
| Keywords | 慢性関節リウマチ (rheumatoid arthritis) 胆道系悪性腫瘍 (biliary tract cancer) 胆嚢癌 (gall bladder cancer) 胆管癌 (bile duct cancer) 乳頭部癌 (cancer of papilla of Vater) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 107 |
| End Page | 114 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308182 |
| JaLCDOI | 10.18926/14993 |
|---|---|
| Title Alternative | Diet therapy with α-linolenic acid-enriched perilla seed oil on pulmonary emphysema. |
| FullText URL | 068_099_106.pdf |
| Author | Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Mifune, Takashi| Okamoto, Makoto| Iwagaki, Naofumi| Hosaki, Yasuhiro| Tsuji, Takao| Tanizaki, Yoshiro| |
| Abstract | 症例は67歳,男性｡主訴は労作時呼吸困難｡【第一回目入院】平成7年9月から12月まで入院し,薬物療法,複合温泉療法を行なった｡自覚症状はやや改善がみられたが,呼吸機能検査所見の改善は得られなかった｡【第二回目入院】平成8年8月から12月まで入院｡n-3系脂肪酸強化食事療法も併用した｡自覚症状および,呼吸機能検査上,FVC,FEV(1.0),PEFなどに改善を認めた｡n-3系脂肪酸はアラキドン酸代謝を通してロイコトリエン合成に関与すると推定されるが,経過中に白血球のLTB(4)産生能の減少を認めた。この症例は肺気腫に対するn-3系脂肪酸強化食事療法の有用性が示唆され,病態を考える上でも興味深いと考えられたので報告する。 |
| Keywords | 肺気腫 (pulmonary emphysema) n-3系脂肪酸 (n-3 fatty acid) 食事療法 (diet therapy) ロイコトリエン合成 (leukotriene) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 99 |
| End Page | 106 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308310 |
| JaLCDOI | 10.18926/14991 |
|---|---|
| Title Alternative | 呼吸器疾患のリハビリテーション.気管支喘息の病態的特徴と関連した温泉療法の効果 |
| FullText URL | 068_080_093.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Iwagaki, Naofumi| Yamamoto, Kazuhiko| |
| Abstract | The number of patients with respiratory disease in the elderly has been increasing in recent years. Pathophysiological characteristic of respiratory diseases in older patients is clearly different from that in younger patients. In this study, rehabilitation for patients with respiratory disease, particularly bronchial asthma, in the elderly was discussed in relation to pathophysiology of asthma. Complex spa therapy has two kinds of actions, direct and indirect actions. Subjective and objective symptoms of patients with asthma are improved by spa therapy for 1-2 months, accompanied with improvement of ventilatory function, and decrease in bronchial hyperresponsiveness and respiratory resistance. In addition to these direct action of spa therapy, increase in strength of respiratory muscle, stability of autonomic nerve syetem, psychical relaxation, and inprovement of suppressed function of adrenocortical glands are observed as indirect action of spa therapy. Regarding clinical asthma type classified by pathophysiological changes of the airways, spa therapy was more effective in patients with hypersecretion and bronchiolar obstruction. These results suggest that complex spa therapy is available as rehabilitation and/or treatment for patients with respiratory disease. |
| Keywords | 気管支喘息 (Bronchial asthma) リハビリテーション (rehabilitation) 複合温泉療法 (complex spa therapy) 換気機能 (ventilatory function) 副腎皮質 (adrenocortical glands) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 80 |
| End Page | 93 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308151 |
| JaLCDOI | 10.18926/14987 |
|---|---|
| Title Alternative | Clinical effect of spa therapy on lumbargo |
| FullText URL | 068_051_058.pdf |
| Author | Okamoto, Makoto| Ashida, Kozo| Yamamoto, Kazuhiko| Iwagaki, Naofumi| Tsugeno, Hirofumi| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine| |
| Abstract | 腰痛症患者12例を対象に温泉療法の臨床効果について検討した｡臨床効果の判定は,日本整形外科学会の腰痛治療成績判定基準に基づき,自覚症状,他覚症状,及び日常生活動作などの項目を中心に,治療前後で比較検討した｡その結果,自覚症状,日常生活動作,総計では,治療前に比べ治療後に有意の改善がみられた｡また改善指数や改善率での検討でも温泉療法の有効性が示唆された｡年齢別(60才以上と60才未満),入院期間(80日以上と80日未満)別の 検討では,65才未満の症例,80日以上の入院の症例において,改善指数,改善率が,有意差はみられなかったもののより高い傾向がみられた｡ |
| Keywords | 腰痛症 (lumbargo) 温泉療法 (spa therapy) 腰痛治療判定基準 (scoring system based on the standard judgement of therapy for lumbargo) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1997-12 |
| Volume | volume68 |
| Start Page | 51 |
| End Page | 58 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308321 |
