ID | 62038 |
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Author |
Matsumoto, Jun
Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kotera, Yumi
Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Watari, Shogo
Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Takeuchi, Koichi
Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Ueki, Hideo
Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Koyama, Toshihiro
Department of Pharmaceuticals Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Wada, Koichiro
Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Fujiyoshi, Masachika
Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Nasu, Yasutomo
Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Ariyoshi, Noritaka
Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Abstract | Background/Aim: This study aimed to elucidate the detailed characteristics of CYP3A5 expression and the association between CYP3A5 expression and clinical outcomes in patients with renal cell carcinoma (RCC). Patients and Methods: This study retrospectively enrolled 124 Japanese patients with RCC treated at the Okayama University Hospital. The commonest CYP3A5 gene polymorphism, CYP3A5*3, and expression levels of CYP3A5 mRNA and protein in each tissue were examined. Results: Expression of CYP3A5 mRNA and protein in RCC tissues was significantly down-regulated compared to that in adjacent normal tissues. High level of CYP3A5 mRNA expression significantly extended cancer-specific survival (p=0.004) and overall survival (p=0.002). The CYP3A5 mRNA expression level was identified as a significant independent prognostic factor for both cancer-specific survival and overall survival. Conclusion: CYP3A5 could serve as a potential marker for prognostication and treatment planning for patients with RCC.
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Keywords | human
cytochrome P450 CYP3A
renal cell carcinoma treatment outcome
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Published Date | 2021-5
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Publication Title |
Anticancer Research
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Volume | volume41
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Issue | issue5
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Publisher | International Institute of Anticancer Research
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Start Page | 2511
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End Page | 2521
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ISSN | 0250-7005
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NCID | AA10625860
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | Copyright © 2021 by The International Institute of Anticancer Research
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.21873/anticanres.15029
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Funder Name |
Japan Society for the Promotion of Science
KAWASAKI Foundation for Medical Science and Medical Welfare
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助成番号 | 20K16043
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Open Access (Publisher) |
non-OA
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