このエントリーをはてなブックマークに追加
ID 56895
Sort Key
4
Title Alternative
Reactivity of secretory immunoglobulin A against gut bacteria is attenuated by high-fat diet consumption
FullText URL
Author
Tsuruta, Takeshi Graduate school of Environmental and Life Sciences, Okayama University
MUHOMAH, Teresia Aluoch Graduate school of Environmental and Life Sciences, Okayama University
Sonoyama, Kei Research Faculty of Agriculture, Hokkaido University
Nishino, Naoki Graduate school of Environmental and Life Sciences, Okayama University
Abstract
Secretory immunoglobulin A (SIgA) is predominant antibody secreted into the gut relating to maintain gut homeostasis. In the present study, we focused on the SIgA coating of gut bacteria as a mucosal immune response affecting the gut bacteria following a high-fat diet (HFD). This study newly showed that the level of SIgA coating of gut bacteria was significantly decreased in HFD-fed mice than normal-fat diet (NFD)-fed mice. Furthermore, we found that the relative abundances of gut bacteria were significantly negatively or positively correlated with the level of SIgA coating of gut bacteria in NFD-fed and HFD-fed mice. Our observations suggest that a decrease in the level of SIgA coating of the gut bacteria through a HFD might relate to HFD-induced changes in bacterial composition.
Note
記念講演要旨(Summary of Commemorational Lecture)
Publication Title
Proceedings of Okayama Association for Laboratory Animal Science
Published Date
2019-06
Volume
volume35
Publisher
岡山実験動物研究会
Publisher Alternative
Okayama Association for Laboratory Animal Science
Start Page
9
End Page
11
Content Type
Conference Paper
OAI-PMH Set
岡山大学
language
日本語
File Version
publisher
Eprints Journal Name
poalas