| JaLCDOI | 10.18926/15336 |
|---|---|
| Title Alternative | Significance of spa therapy in modern medicine and its social request |
| FullText URL | 063_110_116.pdf |
| Author | Tanizaki, Yoshiro| |
| Abstract | ステロイド依存性重症難治性喘息を中心に,温泉療法の臨床効果,作用機序およびその社会的要請について総括的な検討を行った｡1.重症型喘息に対する温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,鉱泥湿布療法などの有効性が高いため,これらの治療法を組合わせた複合温泉療法が現在行われている｡そして,これらの温泉療法は,いずれも細気管支領域の病変(狭窄ないし閉塞)に対して有効であり,気管支肺胞洗浄法(BAL)により観察されるairway inflammationを有する症例が増えつつある現在,極めて有用な治療法の1つと考えられる｡2.入院による温泉療法で軽快した後は,それぞれの地元で継続療法を行うことが症状の安定化のために必要である｡3.重症型喘息は当院への入院例で見る限り,明らかに増加の傾向にあり,薬物療法の限界を越えたこれらの症例の治療には温泉療法が必要であり,周囲環境の変化や高齢化社会を迎えて,その社会的要請は年ごとに増加しつつあると考えられる。 |
| Keywords | 重症型喘息 (Intractable asthma) 温泉プール水泳訓練 (Swimmlng trainlng in a hot spring pool) ヨードゾル吸入療法 (Inhalation therapy with iodine salt solution) 鉱泥湿布療法 (Fango therapy) 複合温泉療法 (Complex spa therapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 110 |
| End Page | 116 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307632 |
| JaLCDOI | 10.18926/15338 |
|---|---|
| Title Alternative | Immunotherapy in house dust mite sensitive asthma |
| FullText URL | 063_117_122.pdf |
| Author | Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takasi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honnke, Naoko| Kusaura, Yasuhiro| Tanizaki, Yoshiro| |
| Abstract | ダニ喘息はアトピー型喘息の典型であるが,これに対する根本療法としてアレルゲンであるハウスダストを皮下注射する免疫療法が臨床でおこなわれている。70-80%の有効性が報告されているが,その作用機序はいまだ不明である｡この稿においては特異的IgE抗体,特異的IgG抗体,特異的lgG4抗体,抗イディオタイプ抗体,肥満細胞の反応性,リンパ球の役割について総説する｡また新たな試みとしてのallergen antibody complexを使った免疫療法,ペプタイドを使用する治療の可能性についても言及する｡ |
| Keywords | ダニ喘息 (House dust mite sensitive bronchial asthma) 免疫療法 (lmmunotherapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 117 |
| End Page | 122 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307745 |
| JaLCDOI | 10.18926/15339 |
|---|---|
| Title Alternative | 抗原および抗ヒトIgEに対する好塩基球の反応性. 1.好塩基球数の変化 |
| FullText URL | 063_123_127.pdf |
| Author | Tanizaki, Yoshiro| Kimura, Ikuro| |
| Abstract | Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood. The peripheral basophil count is at a normal level in non-attack stage of asthmatics as in healthy subjects. The basophil count increases in pre-attack stages, and decreases during attack stages. These findings suggest that number of basophils changes in close relation to asthma cycle, and that by observing number of basophils in the peripheral blood, it is possible to detect near future attacks. The decrease in number of basophils and histamine release by stimulation with antigen and anti-IgE can be observed in vitro in whole blood and basophils separated by density gradient centrifugation and by counterflow centrifugation elutriation. The decreased number of basophils in the peripheral blood represents migration of the cells into local allergic reaction sites. |
| Keywords | basophils (好塩基球) bronchial asthma (気管支喘息) asthma cycle (喘息発作) histamine release (ヒスタミン遊離) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 123 |
| End Page | 127 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307920 |
| JaLCDOI | 10.18926/15341 |
|---|---|
| Title Alternative | 抗原および抗ヒトIgEに対する好塩基球の反応性. 2.分泌機序における形態的変化 |
| FullText URL | 063_128_133.pdf |
| Author | Tanizaki, Yoshiro| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | Morphological changes of blood basophils activated by antigen and anti-IgE were discussed in relation to release mechanisms of the cells. 1. Basophils activated by antigen and anti-IgE show two different types : A form (pear-shaped) and B from (swollen type), on smear preparartions. 2. Pear-shaped basophils(reactive basophils), which appear after stimulation by antigen and anti-IgE, can be observed by the staining solution for the direct count of basophils and eosinophils. 3. The incidence of reactive basophils increases after addition of antigen. Thus, observation of reactive basophils can be clinically applied for detecting allergen (DCRB ; direct connt of reactive basophils). 4. Observation of morphological basophil response by phase- contrast microscopic motion pictures demonstrates that basophils activated by antigen show two different reponses, increase in motility (oriented movement) and degranulation. |
| Keywords | morphological changes of basophils (好塩基球の形態的変化) reactive basophils (反応好塩基球) degranulation (脱顆粒) histamine release (ヒスタミン遊離) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 128 |
| End Page | 133 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| JaLCDOI | 10.18926/15343 |
|---|---|
| Title Alternative | 抗原および抗ヒトIgEに対する抗塩基球の反応性. 3.Ca2(+)の細胞内流入およびヒスタミン遊離 |
| FullText URL | 063_134_141.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE. |
| Keywords | Ca(2+) influx (Ca2+流入) histamine release (ヒスタミン遊離) house dust (ハウスダスト) Candida albicans (カンジダ) anti-lgE (抗ヒトIgE) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 134 |
| End Page | 141 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307872 |
| JaLCDOI | 10.18926/15345 |
|---|---|
| Title Alternative | 気管支喘息の発症における加齢の影響について |
| FullText URL | 063_142_147.pdf |
| Author | Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Tanizaki, Yoshiro| |
| Abstract | Skin tests, serum total IgE levels, specific IgE antibodies against each allergen, bronchial reactions provoked by allergens and histamine release from basophils are well known as prameters of immediate allergic reactions. The incidence of positive immediate skin reaction to allergens such as house dust, ragweed, Aspergillus Alternaria, Cladosporium and Broncasma decreased with aging. On the other hand, the incidence of positive skin reaction to Candida albicans was higher in cases between the age of 41 and 50 and cases over the age of 61 compared to that in the other groups classified by age. Serum IgE levels was highest in cases aged between 0 and 30. The levels of serum IgE decreased with aging. The incidence of positive RAST scores (more than 2+) and positive bronchial reaction to house dust were highest in cases between 0 and 30, and decreased with aging. However, the positive ratio of these tests against C. albicans were highest in cases between 41 and 50. The degree of histamine release from basophils of asthmatics induced by anti-IgE was consistently high without any correlation to aging when their serum IgE levels were more than 501 IU/ml. In the cases with serum IgE levels of less than 300 IU/ml, basophil reactivity to anti-IgE decreasd with aging. Basophil reactivity to house dust was generally dependent on the levels of specific IgE antibodies against the allergen. Although basophil reactivity to C. albicans was also high in cases with positive RAST scores, some cases with a RAST score of 0+ or 1+ showed high or moderate basophil reactivity. Moderate or high reactivity of basophils was frequently observed in cases between 41 and 50 and cases over age 61. |
| Keywords | Skin test (皮内反応) IgE Provocation test (吸入誘発試験) Basophil reactivity (好塩基球の反応性) Aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 142 |
| End Page | 147 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307130 |
| Author | 三朝分院看護部| |
|---|---|
| Published Date | 1992-06 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume63 |
| Content Type | Others |
| Author | Matsubara, Fumie| Endou, Hiroi| Kitani, Hikaru| Tanizaki, Yoshiro| |
|---|---|
| Published Date | 1992-06 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume63 |
| Content Type | Data or Dataset |
| Author | 岡山大学医学部附属病院三朝分院| |
|---|---|
| Published Date | 1992-06 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume63 |
| Content Type | Others |
