ID | 16280 |
Eprint ID | 16280
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FullText URL | |
Title Alternative | Brain active oxygen, free radicals, lipid peroxide and the redox state of glutathione in the Fe(3+) induced epileptic focus of the rat
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Author |
Khochi, Hiroyoshi
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Abstract | Epileptic discharges were induced 15 minutes after 0.1M FeCl(3) was injected into the rat sensory motor cortex and continued for 6 months after the injection. In order to study the Fe(3+) induced seizure mechanism, Fe(3+) bound methemoglobin, free radicals, active oxygen, malondialdehyde and reduced and oxidized glutathione were measured in the foci of rats after the FeCl(3) injection. It was found that Fe(3+) induced a significant increase in Fe(3+) bound methemoglobin, active oxygen and malondialdehyde and accelerated the glutathione redox reaction 5 minutes after the injection. Fe(3+) was thought to induce lipid peroxidation by free radical reaction and thus produce the peileptic focus.
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Keywords | 鉄イオンてんかん
フリーラジカル
活性酸素
過酸化脂質
グルタチオン
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Published Date | 1983-04-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume95
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Issue | issue3-4
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 271
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End Page | 282
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/95/3-4/95_3-4_271/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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