| ID | 16275 |
| Eprint ID | 16275
|
| FullText URL | |
| Title Alternative | Function of peripheral blood lymphocytes in patients with systemic lupus erythematosus. Part 1. Characteristics of spontaneously proliferating cells
|
| Author |
Morimasa, Kimiaki
|
| Abstract | Increased 3H-Thymidine(3H-TdR) uptake was noticed when peripheral blood mononuclear cells (MNC) from systemic lupus erythematosus(SLE) patients were cultured without any mitogenic stimulation. The peak of 3H-TdR uptake was found immediately after transfering the cells to in vitro culture. DNA synthesizing cells were observed directly by means of autoradiography by pulsing with 3H-TdR for 4 hours. Therefore, it was presumed that there were some MNC in the peripheral blood from SLE patients which were already triggered to proliferate in vivo. These spontaneously proliferating MNC were found to fractionate into a nonadherent, non-E-rosette forming and surface immunoglobulin negative cell population, the so called null cell population. These results suggest that there were activated MNC in the peripheral blood from patients with SLE which fractionated into a null cell population.
|
| Keywords | systemic lupus erythematosus
peripheral blood lymphocytes
spontaneously proliferating cells
null cell fraction
|
| Published Date | 1983-04-30
|
| Publication Title |
岡山医学会雑誌
|
| Publication Title Alternative | Journal of Okayama Medical Association
|
| Volume | volume95
|
| Issue | issue3-4
|
| Publisher | 岡山医学会
|
| Publisher Alternative | Okayama Medical Association
|
| Start Page | 233
|
| End Page | 242
|
| ISSN | 0030-1558
|
| NCID | AN00032489
|
| Content Type |
Journal Article
|
| Official Url | https://www.jstage.jst.go.jp/article/joma1947/95/3-4/95_3-4_233/_article/-char/ja/
|
| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
|
| language |
Japanese
|
| Copyright Holders | 岡山医学会
|
| File Version | publisher
|
| Refereed |
True
|
| Eprints Journal Name | joma
|
