ID | 17058 |
Eprint ID | 17058
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FullText URL | |
Title Alternative | Immunological studies on lupus nephritis Part 1. Studies on complement fixing activity of antibody to native DNA
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Author |
Tarumi, Yoshinao
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Abstract | The complement fixing activity of antibody to native DNA (CF-n-DNA antibody) was determined in sera of 93 patients with systemic lupus erythematosus (SLE) by complement fluorescent technique and the following results were obtained. 1. The sera of positive CF-n-DNA antibody had significantly higher n-DNA binding and anti complementary activity, lower complement level and mixed type cryoglobulines. 2. The clinical activity of lupus nephritis was correlated with the frequency of CF-n-DNA antibody. Serial studies of 3 patients with lupus nephritis showed a close correlation between the presence of CF-n-DNA antibody and activity of renal disease. 3. The CF-n-DNA antibody was frequently found in patients who had massive deposition of immune complex along the glomerular basement membrane. 4. Sixteen sera of positive CF-n-DNA antibody were treated by DNase. No significant change in the titer of the antibody was obtained before and after DNase treatment. These date suggest that CF-n-DNA antibody was play an important role of pathogenesis in lupus nephritis.
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Keywords | ループス腎炎
CF-n-DNA 抗体
immune complex
CF-ANF
ACA
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Published Date | 1980-06-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume92
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Issue | issue5-6
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 575
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End Page | 585
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/92/5-6/92_5-6_575/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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