癲癇痙攣伝導様式竝びに痙攣遮断に関する研究 第1編 癲癇痙攣伝導様式に関する実験的研究

Epileptic convulsions were caused by local injection with metrazol in the motor cortex of cats. In each stadium after the onset of convulsions, resections of the motor cortex and lesions between the lenticular nucleus and the brain leg, between the lenticular nucleus and thalamus, between the black substance and red nucleus and between the black substance and peripheral parts was performed. Then the convulsions were continously recorded and investigated using electromyogram. The propagating mechanism was as follows: 1) The stimulation in the motor cortex provocated excitment in the lenticular nucleus and thalamus after a fixed time. Then after another fixed time the excitment in black substance and red nucleus was caused. It means that the excitment part mobilizes to the lower center with the elapse of time. 2) By the resection of the mortor cortex, the convulsions were able to be kept within 2 seconds after the onset of convulsions. Therefore the excitment in the lenticular nucleus and thalamus delayed 2 seconds more. 3) The resection between the lenticular nucleus and brain leg and the total resection between the leuticular nucleus and thalamus and between the black substance and red nucleus can inhibit the convulsion within 12 seconds after its onset. Therefore the excitment in the black substance and red nucleus delayed 12 seconds. 4) The lesion between the black substance and peripheral parts was able to inhibit the convulsions independently from time. It is regarded that, there are no centers in the lower parts, which are influenced by convulsions. 5) In order to have a long duration of the convulsions during a fixed time the the motor cortex must take in it.