Cardiazol痙攣家兎脳髄代謝におよぼすγ-amino-β-hydroxybutyric acidの影響に関する実験的研究 第1編 cardiazol痙攣家兎大脳皮質の遊離アミノ酸含有量およびcholinesterase活性値におよぼすγ-amino-β-hydroxybutyric acidの影響について

The influences of GABOB (γ-amino-β-hydroxybutric acid) upon free amino acid content and ChE activity in cerebral cortex of normal rabbits and those of rabbits after metrazol convulsin were studied. 1) After the injection of 100 mg GABOB, free amino acid nitrogen decreases temporary. Also after that of 10 mg GABOB, it shows a slight decrease. 2) During metrazol convulsion, free amino acid nitrogen content decreases markedly. 3) The intravenous injection of 100 mg GABOB before metrazol convulsion does not influence the variation of free amino acid nitrogen content during convulsion. Positively after that of 10 mg, the decrease of free amino acid nitrogen content by cardiazol convulsion is restrained slightly. 4) By intravenous injection of 100 mg GABOB., ChE activity is accelerated but by that of 10 mg, it is rather restrained. 5) During convulsion, the ChE activity in cerebral cortex decreases markedly. 6) In this case, if 100 mg GABOB is given intravenously before the intravenous injection of metrazol, in the maximum stadium of convulsion antagonistic function is fairly found, but in the latter stadium of convultion it is scarcely influenced. In case of 10 mg GABOB intravenous injection, ChE activity decreases by metrazol convulsion while it shows no sign of being influenced in the maximum stadium of convulsion.