ID | 14456 |
Eprint ID | 14456
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FullText URL | |
Title Alternative | Comparison of Ciclosporin dosage in serum and lymphocytes and suppressive effect on NK activity
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Author |
Inoue, Fumiyuki
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Abstract | Ciclosporin is an effective immunosuppressant for kidney transplantation, although it has the side effect of nephrotoxicity. Ordinarily, the optimal dosage of Ciclosporin is determined by the serum trough level. However, it might be better to make the determination from the concentration in immunocompetent cells. In this report, the serum level of Ciclosporin was compared with the lymphocyte concentration along with the inhibiting activity to NK cells. In in vivo administration, Ciclosporin levels in serum and lymphocytes increased in proportion to the dosage. The suppression of NK activity correlated with the dosage. The suppression of NK activity ceased within 4 days after cessation of administration. In in vitro administration, the Ciclosporin level in lymphocytes increased in proportion to the dosage. The suppression of NK activity correlated with its level in the lymphocytes. Ciclosporin successfully suppressed NK activity against both K562 cells and skin cells.
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Keywords | ciclosporin
NK活性
ラット皮膚細胞
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Note | 原著
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Published Date | 1991-10
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume103
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Issue | issue9-10
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 1065
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End Page | 1073
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/103/9-10/103_9-10_1065/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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