ID | 11867 |
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Sort Key | 6
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Title Alternative | Reactivity and stability of propentdyopent produced by the oxidative cleavage of hemin
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FullText URL | |
Author |
Hirota, Kazuhiro
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Abstract | The water adduct of propentdyopent, which have two propionic acid groups and two methyl groups on two pyrrole rings and a hydroxyl group at the valley position, was prepared by the oxidation of hemin with hydrogen peroxide. Esterification of the two propionic acid groups and substitution of alkoxy group for the hydroxy group were studied to examine the reactivity of the adduct. The esterification took place with the substitution of methoxy group on treatment with a solution of 2% sulfuric acid in methanol at 60℃. The substitutions of methoxy and ethoxy groups were attained without any esterification on treatment with a solution 10% acetic in methanol at 80℃ and a solution of 10% acetic acid in ethanol, respectively. Only esterification was performed on treatment with an ethereal solution of diazomethane. Hydrolysis of the ester occurred simultaneously with the substitution of hydroxyl group for methoxy group on standing with 0.5N hydrochloric acid at room temperature. Those compounds were purified by thin-layer chromatography and identified with mass and nmr spectra.
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Keywords | Propentdyopent
pentdyopent
hemin
oxidation
dipyrrole
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Publication Title |
岡山大学医療技術短期大学部紀要
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Published Date | 1994-01-31
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Volume | volume4
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Publisher | 岡山大学医療技術短期大学部
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Publisher Alternative | School of Health Sciences Okayama University
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Start Page | 31
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End Page | 36
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ISSN | 0917-4494
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NCID | AN10355371
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Content Type |
Departmental Bulletin Paper
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OAI-PMH Set |
岡山大学
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language |
Japanese
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File Version | publisher
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NAID | |
Eprints Journal Name | fhs
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