| JaLCDOI | 10.18926/AMO/63428 |
|---|---|
| FullText URL | 76_2_229.pdf |
| Author | Kono, Takashi| Monden, Nobuya| Chikuie, Nobuyuki| Taruya, Takayuki| Hamamoto, Takao| Ishino, Takashi| Ueda, Tsutomu| Takeno, Sachio| |
| Abstract | We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy. |
| Keywords | head and neck osteosarcomas tumor suppressor p16 |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 229 |
| End Page | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503452 |
| Web of Science KeyUT | 000792291900006 |
| reference | Alessandro F: Epidemiology and classification of bone tumors. Clin Cases Miner Bone Metab (2012) 9: 92.| Smith RB, Apostolakis LW, Karnell LH, Koch BB, Robinson RA, Zhen W, Menck HR and Hoffman HT: National Cancer Data Base report on osteosarcoma of the head and neck. Cancer (2003) 98: 1670-1680.| Isakoff MS, Bielack SS, Meltzer P and Gorlick R: Osteosarcoma: current treatment and a collaborative pathway to success. J Clin Oncol (2015) 33: 3029-3035.| Guadagnolo BA, Zagars GK, Raymond AK, Benjamin RS and Sturgis EM: Osteosarcoma of the jaw/craniofacial region: outcomes after multimodality treatment. Cancer (2009) 115: 3262-3270.| Smeele LE, Kostense PJ, van der Waal I and Snow GB: Effect of chemotherapy on survival of craniofacial osteosarcoma: a systematic review of 201 patients. J Clin Oncol (1997) 15: 363-367.| Asioli S, Righi A, Rucci P, Tarsitano A, Marchetti C, Bacchini P, Balbi T, Bertoni F and Foschini MP: p16 protein expression and correlation with clinical and pathological features in osteosarcoma of the jaws: Experience of 37 cases. Head Neck (2017) 39: 1825- 1831.| Mirabello L, Troisi RJ and Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer (2009) 115: 1531- 1543.| Biermann JS, Chow W, Reed DR, Lucas D, Adkins DR, Agulnik M, Benjamin RS, Brigman B, Budd GT, Curry WT, Didwania A, Fabbri N, Hornicek FJ, Kuechle JB, Lindskog D, Mayerson J, McGarry SV, Million L, Morris CD, Movva S, OʼDonnell RJ, Randall RL, Rose P, Santana VM, Satcher RL, Schwartz H, Siegel HJ, Thornton K, Villalobos V, Bergman MA and Scavone JL: NCCN Guidelines Insights: Bone Cancer, Version 2. 2017. J Natl Compr Canc Netw (2017) 15: 155-167.| Patel SG, Meyers P, Huvos AG, Wolden S, Singh B, Shaha AR, Boyle JO, Pfister D, Shah JP and Kraus DH: Improved outcomes in patients with osteogenic sarcoma of the head and neck. Cancer (2002) 95: 1495-1503.| Matsunobu A, Imai R, Kamada T, Imaizumi T, Tsuji H, Tsujii H, Shioyama Y, Honda H, Tatezaki S and Working Group for Bone and Soft Tissue Sarcomas: Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk. Cancer (2012) 118: 4555- 4563.| Geller DS and Gorlick R: Osteosarcoma: a review of diagnosis, management, and treatment strategies. Clin Adv Hematol Oncol (2010) 8: 705-718.| Kassir RR, Rassekh CH, Kinsella JB, Segas J, Carrau RL and Hokanson JA: Osteosarcoma of the head and neck: meta-analysis of nonrandomized studies. Laryngoscope (1997) 107: 56-61.| Boon E, van der Graaf WTA, Gelderblom H, Tesselaar ME, van Es RJ, Oosting SF, de Bree R, van Meerten E, Hoeben A, Smeele LE, Willems SM, Witjes MJ, Buter J, Baatenburg de Jong RJ, Flucke UE, Peer PG, Bovée JV and Van Herpen CM: Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults. Head Neck (2017) 39: 140-146.| Agarwal P, Sandey M, DeInnocentes P and Bird RC: Tumor suppressor gene p16/INK4A/CDKN2A-dependent regulation into and out of the cell cycle in a spontaneous canine model of breast cancer. J Cell Biochem (2013) 114: 1355-1363.| Tang Y, Yang C, Guo Z, Fu Y, Yu X, Liu B, Zhou H, Wang J, Li W and Pang Q: P16 protein expression as a useful predictive biomarker for neoadjuvant chemotherapy response in patients with high-grade osteosarcoma: A systematic meta-analysis under guideline of PRISMA. Medicine (Baltimore) (2017) 96: e6714.| |
| JaLCDOI | 10.18926/AMO/63427 |
|---|---|
| FullText URL | 76_2_225.pdf |
| Author | Mori, Yu| Sano, Yoshifumi| Sugimoto, Ryujiro| Sakao, Nobuhiko| Ryuko, Tsuyoshi| Takeda, Masashi| Kitazawa, Riko| Yukumi, Shungo| Izutani, Hironori| |
| Abstract | A 75-year-old man presented to our hospital 1 year after partial renal resection for clear cell carcinoma. A right lower lobe lung nodule noted at the time of surgery had increased to 3.0 cm in diameter and was confirmed as squamous cell lung carcinoma by bronchoscopic cytology. Computed tomography had also revealed paratracheal lymph node swelling. He underwent right lower lobectomy with lymph node dissection by video-assisted thoracic surgery. Pathological examination confirmed squamous cell carcinoma of the lung but diagnosed the right hilar and mediastinal lymph node metastases as clear cell carcinoma. |
| Keywords | renal cell carcinoma primary lung cancer double cancer mediastinal lymph node metastasis hilar lymph node metastasis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 225 |
| End Page | 228 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503451 |
| Web of Science KeyUT | 000792291900005 |
| reference | Kanzaki R, Higashiyama M, Okami J and Kodama K: Surgical treatment for patients with solitary metastasis in the mediastinal lymph node from renal cell carcinoma. Interact Cardiovasc Thorac Surg (2009) 8: 485-487.| Arkless R: Renal carcinoma: how it metastasizes. Radiology (1965) 84: 496-501.| Saitoh H: Distant metastasis of renal adenocarcinoma. Cancer (1981) 48: 1487-1491.| King Jr TE, Fisher J, Schwarz MI and Patzelt LH: Bilateral hilar adenopathy: an unusual presentation of renal cell carcinoma. Thorax (1982) 37: 317-318.| Reinke RT, Higgins CB, Niwayama G, Harris RH and Friedman PJ: Bilateral pulmonary hilar lymphadenopathy: an unusual manifestation of metastatic renal cell carcinoma. Radiology (1976) 121: 49-53.| Miyazaki K, Sato S, Kodama T, Kurishima K, Satoh H and Hizawa N: Mediastinal lymph node metastasis of renal cell carcinoma: a case report. Oncol Lett (2016) 11: 1600-1602.| McLoud TC, Kalisher LE, Stark PA and Greene RD: Intrathoracic lymph node metastases from extrathoracic neoplasms. AJR Am J Roentgenol (1978) 131: 403-407.| Wright FW: Enlarged hilar and mediastinal nodes (and especially lower right hilar node enlargement) as a sign of metastasis of a renal tumour. Clin Radiol (1977) 28: 431-436.| Winter H, Meimarakis G, Angele MK, Hummel M, Staehler M, Hoffman RT, Hatz RA and Lohe F: Tumor infiltrated hilar and mediastinal lymph nodes are an independent prognostic factor for decreased survival after pulmonary metastasectomy in patients with renal cell carcinoma. J Urol (2010) 184: 1888-1894.| Whitson BA, Groth SS, Andrade RS, Garrett L, Dudek AZ, Jessurun J and Maddaus MA: Extension of survival by resection of asynchronous renal cell carcinoma metastases to mediastinal lymph nodes. J Thorac Cardiovasc Surg (2008) 135: 1022-1028.| |
| JaLCDOI | 10.18926/AMO/63426 |
|---|---|
| FullText URL | 76_2_217.pdf |
| Author | Yabuno, Satoru| Sasada, Susumu| Umakoshi, Michiari| Nagase, Takayuki| Sugahara, Chiaki| Kawauchi, Satoshi| Yasuhara, Takao| Date, Isao| |
| Abstract | A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery. |
| Keywords | cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 217 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503450 |
| Web of Science KeyUT | 000792291900004 |
| reference | Cervoni L, Celli P, Cantore G and Fortuna A: Intradural tumors of the cauda: a single insitution review of clinical characteristics. Clin Neurol Neurosurg (1995) 97: 8-12.| Choi GH, Oh JK, Kim TY, You NK, Lee HS, Yoon DH, Ha Y, Yi S, Kim DS, Choi JU and Kim KN: The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor. Childs Nerv Syst (2012) 28: 897-904.| Quinn T Ostrom, Peter M de Blank, Carol Kruchko, Claire M Petersen, Peter Liao, Jonathan L Finlay, Duncan S Stearns, Johannes E Wolff, Yingli Wolinsky, John J Letterio and Jill S Barnholtz-Sloan: Alexʼs Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011. Neuro Oncol (2015) 16 Suppl 10: 1-36.| Nakatsu T, Uwabe C and Shiota K: Neural tube closure in humans initiates at multiple sites: evidence from human embryos and implications for he pathogenesis of neural tube defects. 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J Spine Surg (2019) 5: 285-290.| Ozkan N, Jabbarli R, Wrede KH, Sariaslan Z, Stein KP, Dammann P, Ringelstein A, Sure U and Sandalcioglu EI: Surgical management of intradural spinal cord tumors in children and young adults: A single-center experience with 50 patients. Surg Neurol Int (2015) 6: 661-667.| Schellinger KA, Propp JM, Villano JL and McCarthy BJ: Descriptive epidemiology of primary spinal cord tumors. J Neurooncol (2008) 87: 173-179.| Caldarelli M, Massimi L, Kondageski C and Rocco CD: Intracranial midline dermoid and epidermoid cysts in children. J Neurosurg (2004) 100: 473-480.| Wilson PE, Oleszek JL and Clayton GH: Pediatric spinal cord tumors and masses. J Spinal Cord Med (2007) 30: 15-20.| Graham DV, Tampieri D and Villemure JG: Intramedullary dermoid tumor diagnosed with the assistance of magnetic resonance imaging. 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| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| FullText URL | 76_2_203.pdf |
| Author | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| Keywords | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 203 |
| End Page | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
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Int J Cancer (2019) 144: 828-840.| Ao M, Williams K, Bhowmick NA and Hayward SW: Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells. Cancer Res (2006) 66: 8007-8016.| Iwatsuki M, Mimori K, Yokobori T, Ishi H, Beppu T, Nakamori S, Baba H and Mori M: Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci (2010) 101: 293-299.| Tazawa H, Yano S, Yoshida R, Yamasaki Y, Sasaki T, Hashimoto Y, Kuroda S, Ouchi M, Onishi T, Uno F, Kagawa S, Urata Y and Fujiwara T: Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7- epidermal growth factor receptor axis. Int J Cancer (2012) 131: 2939-2950.| Sasaki T, Tazawa H, Hasei J, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Uno F, Kagawa S, Morimoto Y, Urata Y, Ozaki T and Fujiwara T: Preclinical evaluation of telomerase- specific oncolytic virotherapy for human bone and soft tissue sarcomas. Clin Cancer Res (2011) 17: 1828-1838.| Hasei J, Sasaki T, Tazawa H, Osaki S, Yamakawa Y, Kunisada T, Yoshida A, Hashimoto Y, Onishi T, Uno F, Kagawa S, Urata Y, Ozaki T and Fujiwara T: Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells. Mol Cancer Ther (2013) 12: 314-325.| Osaki S, Tazawa H, Hasei J, Yamakawa Y, Omori T, Sugiu K, Komatsubara T, Fujiwara T, Sasaki T, Kunisada T, Yoshida A, Urata Y, Kagawa S, Ozaki T and Fujiwara T: Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas. Sci Rep (2016) 6: 28953.| de Groot RP, Kranenburg O, de Wit L, van den Eijnden-van Raaij J, Mummery C, van der Eb AJ and Zantema A: Adenovirus E1A antagonizes both negative and positive growth signals elicited by transforming growth factor beta 1. Cell Growth Differ (1995) 6: 531-540.| Gervasi M, Bianchi-Smiraglia A, Cummings M, Zheng Q, Wang D, Liu S and Bakin AV: JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming growth factor-beta. J Cell Biol (2012) 196: 589-603.| Ferrari R, Gou D, Jawdekar G, Johnson SA, Nava M, Su T, Yousef AF, Zemke NR, Pellegrini M, Kurdistani SK and Berk AJ: Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection. Cell Host Microbe (2014) 16: 663-676.| Chang H, Liu Y, Xue M, Liu H, Du S, Zhang L and Wang P: Synergistic action of master transcription factors controls epithelial- to-mesenchymal transition. Nucleic Acids Res (2016) 44: 2514- 2527.| Mizushima N and Komatsu M: Autophagy: renovation of cells and tissues. Cell (2011) 147: 728-741.| Jiang Y, Woosley AN, Sivalingam N, Natarajan S and Howe PH: Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-betainduced autophagy. Nat Cell Biol (2016) 18: 851-863.| Tazawa H, Kagawa S and Fujiwara T: Oncolytic adenovirusinduced autophagy: tumor-suppressive effect and molecular basis. Acta Med Okayama (2013) 67: 333-342.| Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Pure E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT and Werb Z: A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer (2020) 20: 174-186.| |
| JaLCDOI | 10.18926/AMO/63414 |
|---|---|
| FullText URL | 76_2_195.pdf |
| Author | Inoue, Shinichiro| Maeda, Isseki| Ogawa, Asao| Yoshiuchi, Kazuhiro| Terada, Seishi| Yamada, Norihito| |
| Abstract | The clinical benefit of perospirone for treatment of delirium in patients with advanced cancer is not sufficiently clear. The objective of this study was to compare the safety and effectiveness of perospirone to those of risperidone for the treatment of delirium in patients with advanced cancer. This is a secondary analysis of a multicenter prospective observational study in nine psycho-oncology consultation services in Japan. The study used the Delirium Rating Scale (DRS) Revised-98 to measure effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 to assess safety. Data from 16 patients who received perospirone and 53 patients who received risperidone were analyzed. The mean age was 70 years in the perospirone group and 73 years in the risperidone group. Both groups showed a significant decrease in the total score of DRS-R-98 after three days of treatment (perospirone: 11.7 (7.9-15.4) to 7.0 (3.3-10.7), difference −4.7, effect size=0.72, p=0.003; risperidone: 15.5 (13.6-17.4) to 12.2 (10.1-14.2), difference −3.3, effect size=0.55, p=0.00). The risperidone group showed significant improvements in sleep-wake cycle disturbance, orientation, attention, and visuospatial ability. In the perospirone group, there was a significant improvement of sleep-wake cycle disturbance. The median daily dose of perospirone was 4 mg/day. There were fewer episodes of somnolence as an adverse event in the perospirone group. Low-dose perospirone was thus found to be effective for the treatment of delirium in patients with advanced cancer and may be associated with fewer episodes of over-sedation as an adverse event. |
| Keywords | delirium cancer perospirone risperidone |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 195 |
| End Page | 202 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503448 |
| Web of Science KeyUT | 000792291900002 |
| JaLCDOI | 10.18926/AMO/63413 |
|---|---|
| FullText URL | 76_2_187.pdf |
| Author | Ren, Wanxu| Matsusaki, Takashi| Abugri Osman Bright| Morimatsu, Hiroshi| |
| Abstract | Remifentanil is an ultra-short-acting opioid that sometimes causes opioid-induced hyperalgesia, which has led to controversy regarding the association between intraoperative remifentanil administration and postoperative pain. This study aimed to assess the effects of the intraoperative remifentanil dose on postoperative pain. Patients undergoing esophageal, gastric/hepatobiliary, or intestinal/colon surgery and using postoperative patient-controlled epidural analgesia were analyzed. The patients were divided into two groups based on the average intraoperative remifentanil dose (high-dose remifentanil [HR] group: ≥0.1 μg/kg/min; low-dose remifentanil [LR] group: <0.1 μg/kg/min). In all, 406 patients met the inclusion criteria. A significant difference in the average dose of remifentanil was seen between the groups during the anesthesia period (0.14±0.05 vs. 0.07±0.02 μg/kg/min). However, no significant difference was seen in pre- or intraoperative patient characteristics. Numerical rating scale (NRS) scores on postoperative day 1 were similar between the groups (HR: 1.7±2.0; LR: 1.7±2.0; p=0.74). The incidence of poor pain control (NRS > 3/10) was also similar between the groups (HR: 14%; LR: 16%; p=0.57). Older age (> 60 years) and type of surgery (esophageal surgery) were associated with worse postoperative NRS scores. No significant association was seen between the intraoperative remifentanil dose and postoperative NRS scores following thoracoabdominal surgery with postoperative epidural pain management. |
| Keywords | high-dose remifentanil postoperative numerical rating scale type of surgery epidural block |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 187 |
| End Page | 193 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503447 |
| Web of Science KeyUT | 000792291900001 |
| JaLCDOI | 10.18926/AMO/63412 |
|---|---|
| FullText URL | 76_2_179.pdf |
| Author | Higashi, Tomoko| Murata, Naomichi| Fujimoto, Maki| Miyake, Saki| Egusa, Masahiko| Higuchi, Hitoshi| Maeda, Shigeru| Miyawaki, Takuya| |
| Abstract | Patients with neurodegenerative diseases are at an increased risk of dysphagia and aspiration pneumonia. In this study, we examined whether ingestion of capsaicin prior to swallowing changes the temporal dynamics of swallowing in such patients. In a crossover, randomized controlled trial, 29 patients with neurodegenerative diseases were given a soluble wafer containing 1.5 μg capsaicin or an identical placebo 20 min prior to testing. For evaluation with video fluoroscopy (VF), patients consumed a barium-containing liquid plus thickening material. The durations of the latency, elevating and recovery periods of the hyoid were assessed from VF. Overall, no significant differences were observed in the duration of each period between capsaicin and placebo treatments. However, reductions in the latency and elevating periods were positively correlated with baseline durations. In subgroup analyses, that correlation was observed in patents with amyotrophic lateral sclerosis (ALS) but not in patients with Parkinson’s disease. The consumption of wafer paper containing capsaicin before the intake of food may be effective in patients with dysphagia related with certain neurodegenerative diseases, particularly ALS patients. Further studies will be needed to validate this finding. |
| Keywords | deglutition disorder fluoroscopy neurodegenerative diseases amyotrophic lateral sclerosis Parkinson disease |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 179 |
| End Page | 186 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503446 |
| Web of Science KeyUT | 000792374900010 |
| reference | Onesti E, Schettino I, Gori MC, Frasca V, Ceccanti M, Cambieri C, Ruoppolo G and Inghilleri M: Dysphagia in Amyotrophic Lateral Sclerosis: Impact on Patient Behavior, Diet Adaptation, and Riluzole Management. Front Neurol (2017) 8: 94.| Karam C, Scelsa SN and MacGowan DJL: The clinical course of progressive bulbar palsy. Amyotroph Lateral Scler (2010) 11: 364- 368.| Suttrup I and Warnecke T: Dysphagia in Parkinsonʼs Disease. Dysphagia (2016) 31: 24-32.| Kalf JG, de Swart BJM, Bloem BR and Munneke M: Prevalence of oropharyngeal dysphagia in Parkinsonʼs disease: A meta-analysis. Parkinsonism Relat Disord (2012) 18: 311-315.| Lee HH, Seo HG, Kim K, Lee SH, Lee WH, Oh B-M, Lee WW, Kim Y, Kim A, Kim HJ, Jeon B and Han TR: Characteristics of | Early Oropharyngeal Dysphagia in Patients with Multiple System Atrophy. Neurodegener Dis (2018) 18: 84-90.| Clark HM, Stierwalt JAG, Tosakulwong N, Botha H, Ali F, Whitwell JL and Josephs KA: Dysphagia in Progressive Supranuclear Palsy. Dysphagia (2020) 35: 667-676.| Iglesias C, Sangari S, El Mendili M-M, Benali H, Marchand- Pauvert V and Pradat P-F: Electrophysiological and spinal imaging evidences for sensory dysfunction in amyotrophic lateral sclerosis. BMJ open (2015) 5: e007659.| Pugdahl K, Fuglsang-Frederiksen A, de Carvalho M, Johnsen B, Fawcett PRW, Labarre-Vila A, Liguori R, Nix WA and Schofield IS: Generalised sensory system abnormalities in amyotrophic lateral sclerosis: a European multicentre study. J Neurol Neurosurg Psychiatry (2007) 78: 746-749.| Mochizuki Y, Mizutani T, Warabi Y, Shimizu T and Isozaki E: The somatosensory cortex in multiple system atrophy. J Neurosurg Sci (2008) 271: 174-179.| Mu L, Sobotka S, Chen J, Su H, Sanders I, Nyirenda T, Adler, Charles H, Shill HA, Caviness JN, Samanta JE, Sue LI and Beach TG: Parkinson Disease Affects Peripheral Sensory Nerves in the Pharynx. J Neuropathol Exp Neurol (2013) 72: 614-623.| Ebihara T, Sekizawa K, Nakazawa H and Sasaki H: Capsaicin and swallowing reflex. Lancet (1993) 341: 432.| Ebihara T, Takahashi H, Ebihara S, Okazaki T, Sasaki T, Watando A, Nemoto M and Sasaki H: Capsaicin Troche for Swallowing Dysfunction in Older People. J Am Geriatrics Soc (2005) 53: 824-828.| Tomsen N, Ortega O, Rofes L, Arreola V, Martin A, Mundet L and Clavé P: Acute and subacute effects of oropharyngeal sensory stimulation with TRPV1 agonists in older patients with oropharyngeal dysphagia: a biomechanical and neurophysiological randomized pilot study. Therap Adv Gastroenterol (2019) 12: 1-13.| Jinnouchi O, Ohnishi H, Kondo E, Kawata I, Bando H, Okamoto H, Azuma T, Sato G, Kitamura Y, Abe K and Takeda N: Aural stimulation with capsaicin prevented pneumonia in dementia patients. Auris Nasus Larynx (2019) 47: 154-157.| Nakato R, Manabe N, Shimizu S, Hanayama K, Shiotani A, Hata J and Haruma K: Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study. Digestion (2017) 95: 210-220.| Burgos R, Bretón I, Cereda E, Desport JC, Dziewas R, Genton L, Gomes, Filomena Jésus P, Leischker A, Muscaritoli M, Poulia KA, Preiser JC, Van der Marck M, Wirth R, Singer P and Bischoff SC: ESPEN guideline clinical nutrition in neurology. Clin Nutr (2018) 37: 354-396.| Goto T, Murata N, Arioka T, Kanda Y, Kobayashi Y, Mori T, Miyawaki T and Egusa M: Accelerating effect in swallowing reflex by Taking Capcisine Film. J Jpn Soc Dysphagia Rehab (2013) 17: 209-216.| Horiguchi S and Suzuki Y: Screening tests in evaluating swallowing function. Jpn Med Assoc J (2011) 54: 31-34.| Wallace E, Guiu Hernandez E, Ang A, Hiew S and Macrae P: A systematic review of methods of citric acid cough reflex testing. Pulmonary Pharmacol Ther (2019) 58: 101827.| Magara J, Hayashi H, Kanda C, Hori K, Taniguchi H, Ono K and Inoue M: Spatial and temporal relationship between swallowrelated hyoid movement and bolus propulsion during swallowing. J Jpn Soc Stomatognathic Function (2013) 20: 22-32.| Dodds W, Taylor A, Stewart E, Kern M, Logemann J and Cook I: Tipper and dipper types of oral swallows. Am J Roentgenol (1989) 153: 1197-1199.| Rofes L, Arreola V, Mukherjee R and Clavé P: Sensitivity and specificity of the Eating Assessment Tool and the Volume-Viscosity Swallow Test for clinical evaluation of oropharyngeal dysphagia. Neurogastroenterol Motil (2014) 26: 1256-1265.| Kendall KA and Leonard RJ: Hyoid Movement During Swallowing in Older Patients With Dysphagia. Arch Otolaryngol Head Neck Surg (2001) 127: 1224-1229.| Rofes L, Arreola V, Martin A and Clavé P: Natural capsaicinoids improve swallow response in older patients with oropharyngeal dysphagia. Gut (2013) 62: 1280-1287.| Szolcsányi J: Forty years in capsaicin research for sensory pharmacology and physiology. Neuropeptides (2004) 38: 377-384.| Okano H, Koike S, Bamba H, Toyoda K, Uno T and Hisa Y: Participation of TRPV1 and TRPV2 in the rat laryngeal sensory innervation. Neurosci Lett (2006) 400: 35-38.| Tang H-B, Inoue A, Iwasa M, Hide I and Nakata Y: Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin. J Neurochem (2006) 97: 1412-1418.| Sivarao D and Goyal RK: Functional anatomy and physiology of the upper esophageal sphincter. Am J Med (2000) 108: 27-37.| Vijayakumar UG, Milla V, Cynthia Stafford MY, Bjourson AJ, Duddy W and Duguez SM-R: A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS. Front Neurol (2019) 10: 1-17.| Kawai S, Tsukuda M, Mochimatsu I, Enomoto H, Kagesato Y, Hirose H, Kuroiwa Y and Suzuki Y: A Study of the Early Stage of Dysphagia in Amyotrophic Lateral Sclerosis. Dysphagia (2003) 18: 1-8.| Steele CM and Miller AJ: Sensory Input Pathways and Mechanisms in Swallowing: A Review. Dysphagia (2010) 25: 323-333.| Rofes L, Ortega O, Vilardell N, Mundet L and Clavé P: Spatiotemporal characteristics of the pharyngeal event-related potential in healthy subjects and older patients with oropharyngeal dysfunction. Neurogastroenterol Motil (2017) 29: e12916.| Cabib C, Ortega O, Vilardell N, Mundet L, Clavé P and Rofes L: Chronic post-stroke oropharyngeal dysphagia is associated with impaired cortical activation to pharyngeal sensory inputs. Eur J Neurol (2017) 24: 1355-1362.| Clavé P and Shaker R: Dysphagia: current reality and scope of the problem. Nat Rev Gastroenterol Hepatol (2015) 12: 259-270.| Tiago R, Pontes P and Brasil OC do: Age-Related Changes in Human Laryngeal Nerves. Otolaryngology‒Head and Neck Surgery (2007) 136: 747-751.| Kaneoka A, Pisegna JM, Inokuchi H, Ueha R, Goto T, Nito T, Stepp CE, LaValley MP, Haga N and Langmore SE: Relationship Between Laryngeal Sensory Deficits, Aspiration, and Pneumonia in Patients with Dysphagia. Dysphagia (2018) 33: 192-199.| |
| JaLCDOI | 10.18926/AMO/63411 |
|---|---|
| FullText URL | 76_2_173.pdf |
| Author | Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro| |
| Abstract | To the best of our knowledge, no previous studies have reported a relationship between osteoarthritis (OA) of the lower limbs and OA of the shoulder joints. We evaluated the correlation between shoulder OA and hip OA. We collected contrast-enhanced computed tomography (CECT) images of the shoulder joints of 159 patients with hip OA who underwent primary total hip arthroplasty (THA). The images, taken 1 week after THA to monitor venous thromboembolism (VTE), were used to examine the prevalence of shoulder OA. They were compared with those of 103 controls who underwent CECT during the same period to monitor VTE. Shoulder OA was observed in 15% of the controls and 24% of the THA patients. Although the rate was somewhat higher in the THA group, the difference was not significant. However, in the THA group, significantly more patients with bilateral hip OA (33%) had shoulder OA than those with unilateral hip OA (17%). In summary, the prevalence of shoulder OA was significantly higher in patients with bilateral hip OA. In these patients, pain and instability in the hip joints require them to use arm support to stand up or walk, putting the weight-bearing shoulder at risk of developing OA. |
| Keywords | shoulder osteoarthritis hip osteoarthritis weight-bearing shoulder total hip arthroplasty |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 173 |
| End Page | 177 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503445 |
| Web of Science KeyUT | 000792374900009 |
| reference | Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, Howell D, Kaplan D, Koopman W, Longley III S, Mankin H, McShane DJ, Medsger Jr. T, Meenan R, Mikkelsen W, Moskowitz R, Murphy W, Rothschild B, Segal M, Sokoloff L and Wolfe F: Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum (1986) 29: 1039-1049.| Lane NE, Brandt K, Hawker G, Peeva E, Schreyer E, Tsuji W and Hochberg MC: OARSI-FDA initiative: defining the disease state of osteoarthritis. Osteoarthr Cartil (2011) 19: 478-482.| Offierski CM and MacNab I: Hip-spine syndrome. Spine (1976) 8: 316-321.| Smillies IS: Angular deformity; in Diseases of the knee joint. 2nd ed., Churchill Livingstone, London (1974).| Liu N, Goodman SB, Lachiewicz PF and Wood KB: Hip or spine surgery first?: a survey of treatment order for patients with concurrent degenerative hip and spinal disorders. Bone Joint J (2019) 101-B(6_Supple_B): 37-44.| Riviere C, Lazennec JY, Van Der Straeten C, Auvinet E, Cobb J and Muirhead-Allwood S: The influence of spine-hip relations on total hip replacement: A systematic review. Orthop Traumatol Surg Res (2017) 103: 559-568.| Someya S, Sonohata M, Ida S, Nagamine S, Tajima T and Mawatari M: Lower limb alignment in patients with a unilateral completely dislocation hip. Open Orthop J (2016) 10: 448-456.| Kircher J, Morhard M, Magosch P, Ebinger N, Lichtenberg S and Habermeyer P: How much are radiological parameters related to clinical symptoms and function in osteoarthritis of the shoulder? Int Orthop (2010) 34: 677-681.| Nakagawa Y, Hyakuna K, Otani S, Hashitani M and Nakamura T: Epidemiologic study of glenohumeral osteoarthritis with plain radiography. J Shoulder Elbow Surg (1999) 8: 580-584.| van Schaardenburg D, Van den Brande KJ, Ligthart GJ, Breedveld FC and Hazes JM: Musculoskeletal disorders and disability in persons aged 85 and over: a community survey. Ann Rheum Dis (1994) 53: 807-811.| Dagenais S, Garbedian S and Wai EK: Systematic review of the prevalence of radiographic primary hip osteoarthritis. Clin Orthop Relat Res (2009) 467: 623-637.| Iidaka T, Muraki S, Akune T, Oka H, Kodama R, Tanaka S, Kawaguchi H, Nakamura K and Yoshimura N: Prevalence of radiographic hip osteoarthritis and its association with hip pain in Japanese men and women: the ROAD study. Osteoarthritis Cartilage (2016) 24: 117-123.| Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, Ishibashi H, Kawaguchi H, Nakamura K and Akune T: Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab (2009) 27: 620-628.| Kobayashi T, Takagishi K, Yamamoto A, Shitara H, Ichinose T, Shimoyama D and Ishiwata S: The prevalence of shoulder osteoarthritis in middle and old age: association with risk factors and shoulder function. J Shoulder Elb Surg (2012) 21: e28.| Oh JH, Chung SW, Oh CH, Kim SH, Park SJ, Kim KW, Park JH, Lee SB and Lee JJ: The prevalence of shoulder osteoarthritis in the elderly Korean population: association with risk factors and function. J Shoulder Elbow Surg (2011) 20: 756-763.| Wing PC and Tredwell SJ: The weightbearing shoulder. Paraplegia (1983) 21: 107-113.| Bayley JC, Cochran TP and Sledge CB: The weight bearing shoulder. The impingement syndrome in paraplegics. J Bone Joint Surg Am (1987) 69: 676-678.| Akbar M, Balean G, Brunner M, Seyler TM, Bruckner T, Munzinger J, Grieser T, Gerner HJ and Loew M: Prevalence of rotator cuff tear in paraplegic patients compared with controls. J Bone Joint Surg Am (2010) 92: 23-30.| Escobedo EM, Hunter JC, Hollister MC, Patten RM and Goldstein B: MR imaging of rotator cuff tears in individuals with paraplegia. AJR Am J Roentgenol (1997) 168: 919-923.| Patel RM, Gelber JD and Schickendantz MS: The weight-bearing shoulder. J Am Acad Orthop Surg (2018) 26: 3-13.| |
| JaLCDOI | 10.18926/AMO/63410 |
|---|---|
| FullText URL | 76_2_167.pdf |
| Author | Higashionna, Tsukasa| Ushio, Soichiro| Esumi, Satoru| Murakawa, Kiminaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Abstract | Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. The aim of this study was to retrospectively compare the efficacy and safety of CZOP at a dose of 1 g three times daily to those of cefepime (CFPM) in the treatment of FN in our lung cancer patients. The response rates of the CZOP and CFPM groups were 89.5% (17/19 cases) and 83.0% (39/47 cases), respectively, with no significant difference between the two groups. The median duration of antimicrobial treatment was 6 days (4-10 days) in the CZOP group and 7 days (3-13 days) in the CFPM group, with no significant difference between groups. The incidence rates of adverse events were 21.1% (4/19 cases) in the CZOP group and 19.1% (9/47 cases) in the CFPM group. No adverse events of Grade 3 or higher were observed in either group. The findings of the present study suggest that CZOP administration at a dose of 1 g three times per day as an antimicrobial treatment alternative against FN. |
| Keywords | febrile neutropenia cefozopran cefepime lung cancer retrospective |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 167 |
| End Page | 172 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503444 |
| Web of Science KeyUT | 000792374900008 |
| JaLCDOI | 10.18926/AMO/63409 |
|---|---|
| FullText URL | 76_2_155.pdf |
| Author | Kimura, Jiro| Okabayashi, Takehiro| Sui, Kenta| Tabuchi, Motoyasu| Iwata, Jun| Hata, Yasuhiro| Iiyama, Tatsuo| Ono, Noriaki| |
| Abstract | Small bowel metastasis from renal cell carcinoma (RCC) is rare, and its clinicopathological characteristics are unclear; thus, we revisited the concept of this tumor and reviewed its diagnostic and treatment modalities. We filtered MEDLINE searches of articles published in English between 1950 and 2019, and identified 100 patients who had undergone treatment, including 1 patient from our clinic. We extracted patient characteristics, treatment, and prognostic data, resulting in clinicopathological data on 100 patients (83 men, 17 women). Mean age was 63 years (range, 16-86 years). Tumor sites were duodenum, jejunum, ileum, and multiple sites in 30, 37, 25, and 7 patients, respectively. The 1-, 3-, and 5-year overall survival rates after diagnosis were 53.0%, 36.0%, and 36.0%. Curative resection patients showed 62.1% 5-year survival after surgery, vs. 27.5% in noncurative surgical management cases. Good prognoses can be expected if these tumors are identified early for complete removal. Surgery is the only curative option. To determine the best management strategy and improve prognostic accuracy, we continue to collect and analyze epidemiological and pathological data. Although this condition is rare, surgery should be considered if curative resection is expected. Prognosis after curative resection is not poor, but recurrence is not unlikely. |
| Keywords | renal cell carcinoma small bowel metastasis intestine tumor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 155 |
| End Page | 165 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503443 |
| Web of Science KeyUT | 000792374900007 |
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| JaLCDOI | 10.18926/AMO/63408 |
|---|---|
| FullText URL | 76_2_145.pdf |
| Author | Qin, Yi| Liu, Linlin| Zhu, Fanghui| Lu, Huazhen| Huang, Mingliu| |
| Abstract | With rapidly aging populations, family care functions can become weakened, and community health services often lack unified standards. A standardized and professional community home-based long-term care model (CHLCM) for the elderly is urgently needed in many regions of China and in other countries. Here, we explored the indicators of the need for a CHLCM among elderly individuals, and we constructed a CHLCM. We created and distributed a questionnaire regarding the requirement of long-term care services, based on a literature review. The two-rounds Delphi method was used, involving 20 experts who were randomly selected from among the medical universities, community health service centers, and nursing homes in Nanning, Guangxi, China. The experts’ enthusiasm rates in the questionnaire’s two rounds were 95% and 100%, respectively. The authentic coefficient of the experts’ consulting was 0.857, and that of the experts’ academic level was 0.835; the judgement coefficient was 0.880 and the familiar coefficient was 0.855. The CHLCM includes service content and an evaluation. The coordination coefficients for the two primary, eight secondary, and 29 tertiary indicators were 0.200, 0.386, and 0.184, respectively (p<0.05). The experts’ enthusiasm and authority were high. The coordination of the experts’ agreement was sufficient, and the analysis results were reliable. The CHLCM includes 29 items that provide a foundation and references for the formulation of concrete indicators and subsequent research. |
| Keywords | community home-based long-term care elderly indicator system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 145 |
| End Page | 154 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503442 |
| Web of Science KeyUT | 000792374900006 |
| reference | Fang EF, Xie C, Schenkel JA, Wu C, Long Q, Cui H, Aman Y, Frank J, Liao J, Zou H, Wang NY, Wu J, Liu X, Li T, Fang Y, Niu Z, Yang G, Hong J, Wang Q, Chen G, Li J, Chen HZ, Kang L, Su H, Gilmour BC, Zhu X, Jiang H, He N, Tao J, Leng SX, Tong T and Woo J: A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Res Rev (2020) 64: 101174.| Du P, Dong T and Ji J: Current Status of the Long-term Care Security System for Older Adults in China. Res Aging (2021) 43: 136-146.| Mortenson LC: Long-Term Care: Home- and Community-Based Services. Issue Brief Health Policy Track Serv (2017) 2017: 1-51.| Kimura H, Nishio M, Kukihara H, Koga K and Inoue Y: The role of caregiver burden in the familial functioning, social support, and quality of family life of family caregivers of elders with dementia. 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Washingdon, D.C., United States: World Bank Publications (2018).| Hrženjak M: Precarious Situations of Care Workers in Home-Based Elder Care in Slovenia. New solutions: a journal of environmental and occupational health policy: New Solut (2018) 27: 483-500.| Li P, Lv YH, Ma L, Yang SH, Xiang Y, Lei Q, Du GD and Huang DJ: [Research of the Epworth sleepiness scale based on ruzzy comprehensive evaluation]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2017) 31: 356-360 (in Chinese).| Quality management systems - Requirements. International Organization for Standardization. ISO/DID 9001: 2015.| Schöne G, Damerow S, Hölling H, Houben R and Gabrys L: [Method for the quality assessment of data collection processes in epidemiological studies]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (2017) 60: 1109-1114 (in German).| Humphrey-Murto S, Wood TJ, Gonsalves C, Mascioli K and Varpio L: The Delphi Method. 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Rev Infirm (2020) 69: 33-35 (in French).| |
| JaLCDOI | 10.18926/AMO/63407 |
|---|---|
| FullText URL | 76_2_137.pdf |
| Author | Tsukahara, Masaru| So, Ryuhei| Yada, Yuji| Kodama, Masafumi| Kishi, Yoshiki| Yamada, Norihito| |
| Abstract | Although reported for Caucasians, changes in plasma clozapine levels after smoking cessation in East Asians remain unclear. We here investigated plasma clozapine levels before and after smoking cessation in Japanese inpatients with schizophrenia. We conducted a retrospective chart review of 14 inpatients with schizophrenia who were being treated with clozapine between June 1, 2019, and July 31, 2019 and who were smokers as of July 1, 2019, the day on which a smoking ban was instituted in the tertiary public psychiatric hospital. The primary outcome was individual differences in plasma clozapine levels between before and after the smoking ban, which were compared using paired t-tests. The mean plasma clozapine level was significantly increased, by 213.4 ng/mL (95% CI 119.9-306.8; p<0.01) or 53.2%. Four of the 14 inpatients experienced clinically significant side effects, such as myoclonus, drooling, and amnesia, due to the development of high plasma clozapine levels. Our findings indicated that close monitoring of plasma clozapine levels before and after smoking cessation and prior dose adjustment of clozapine may be necessary, to prevent a significant risk of developing high plasma clozapine levels, even in Japanese patients. |
| Keywords | Asian clozapine schizophrenia smoking |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 137 |
| End Page | 143 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503441 |
| Web of Science KeyUT | 000792374900005 |
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Bone Marrow Transplant (2013) 48: 452-458.| Murayama-Sung L, Ahmed I, Goebert D, Alaimalo E and Sung H: The impact of hospital smoking ban on clozapine and norclozapine levels. J Clin Psychopharmacol (2011) 31: 124-126.| Chang WH, Lin SK, Lane HY, Hu WH, Jann MW and Lin HN: Clozapine dosages and plasma drug concentrations. J Formos Med Assoc (1997) 96: 599-605.| Chong SA, Tan CH, Khoo YM, Lee HS, Wong KE, Ngui F and Winslow M: Clinical evaluation and plasma clozapine concentrations in Chinese patients with schizophrenia. Ther Drug Monit (1997) 19: 219-223.| Carrillo JA, Herraiz AG, Ramos SI and Benítez J: Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients. J Clin Psychopharmacol (1998) 18: 311- 316.| Shimada T, Yamazaki H, Mimura M, Inui Y and Guengerich FP: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther (1994) 270: 414-423.| Sachse C, Brockmöller J, Bauer S and Roots I: Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br. J Clin Pharmacol (1999) 47: 445-449.| Ghotbi R, Christensen M, Roh HK, Ingelman-Sundberg M, Aklillu E and Bertilsson L: Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur J Clin Pharmacol (2007) 63: 537- 546.| Tsuda Y, Saruwatari J and Yasui-Furukori N: Meta-analysis: The effects of smoking on the disposition of two commonly used antipsychotic agents, olanzapine and clozapine. BMJ Open (2014) 4: e004216.| Inada K, Oshibuchi H, Ishigooka J and Nishimura K: Analysis of clozapine use and safety by using comprehensive national data from the Japanese clozapine patient monitoring service. J Clin Psychopharmacol (2018) 38: 302-306.| |
| JaLCDOI | 10.18926/AMO/63406 |
|---|---|
| FullText URL | 76_2_129.pdf |
| Author | Kubo, Kotaro| Nakamura, Keiichiro| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Ida, Naoyuki| Haruma, Tomoko| Ogawa, Chikako| Masuyama, Hisashi| |
| Abstract | Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC. |
| Keywords | D-dimer gynecologic cancer venous thromboembolism |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503440 |
| Web of Science KeyUT | 000792374900004 |
| reference | Mandalà M, Falanga A, Roila F, ESMO Guidelines Working Group: Venous thromboembolism in cancer patients: ESMO Clinical Practice Guidelines for the management. Ann Oncol (2010) 21 Suppl 5: v274-v276.| Key NS, Khorana AA, Mackman N, McCarty OJ, White GC, Francis CW, McCrae KR, Palumbo JS, Raskob GE, Chan AT and Sood AK: Thrombosis in cancer: Research priorities identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group. Cancer Res (2016) 76: 3671- 3675.| Khorana AA, Kuderer NM, Culakova E, Lyman GH and Francis CW: Development and validation of a predictive model for chemotherapy- associated thrombosis. Blood (2008) 111: 4902-4907.| Timp JF, Braekkan SK, Versteeg HH and Cannegieter SC: Epidemiology of cancer-associated venous thrombosis. Blood (2013) 122: 1712-1723.| Kogan AE, Mukharyamova KS, Bereznikova AV, Filatov VL, Koshkina EV, Bloshchitsyna MN and Katrukha AG: Monoclonal antibodies with equal specificity to D-dimer and high-molecularweight fibrin degradation products. Blood Coagul Fibrinolysis (2016) 27: 542-550.| Ma X, Li Y, Zhang J, Huang J and Liu L: Prognostic role of D-dimer in patients with lung cancer: a meta-analysis. Tumour Biol (2014) 35: 2103-2109.| Fregoni V, Regolo L, Da Prada GA, Zambelli A, Baiardi P, Zanini V, Villani L, Pavesi L and Riccardi A: No correlation between plasma D-dimer levels and lymph node involvement in operable breast cancer. Breast (2012) 21: 220.| İnal T, Anar C, Polat G, Ünsal İ and Halilçolar H: The prognostic value of D-dimer in lung cancer. Clin Respir J (2015) 9: 305-313.| Libby P: Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol (2012) 32: 2045-2051.| Lippi G, Favaloro EJ, Montagnana M and Franchini M: C-reactive protein and venous thromboembolism: causal or casual association? Clin Chem Lab Med (2010) 48: 1693-1701.| Fox EA and Kahn SR: The relationship between inflammation and venous thrombosis. A systematic review of clinical studies. Thromb Haemost (2005) 94: 362-365.| Folsom AR, Lutsey PL, Heckbert SR and Cushman M: Serum albumin and risk of venous thromboembolism. Thromb Haemost (2010) 104: 100-104.| Shah MA, Capanu M, Soff G, Asmis T and Kelsen DP: Risk factors for developing a new venous thromboembolism in ambulatory patients with non-hematologic malignancies and impact on survival for gastroesophageal malignancies. J Thromb Haemost (2010) 8: 1702-1709.| Mulder Fr, Candeloro M, Kamphuisen PW, Di Nisio M, Bossuyt PM, Guman N, Smit K, Büller HR, and Nick van Es2 on behalf of the CAT-prediction Collaborators: Haematologica (2019) 104: 1277- 1287.| Khorana AA: Cancer and coagulation. Am J Hematol (2012) 87 Suppl 1; S82-S87.| Forrest LM, McMillan DC, McArdle CS, Angerson WJ and Dunlop DJ: Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-smallcell lung cancer. Br J Cancer (2003) 89: 1028-1030.| Mochizuki S, Yoshino T, Kojima T, Fuse N, Ikematsu H, Minashi K, Yano T, Tahara M, Kaneko K, Doi T, Koike K and Ohtsu A: Therapeutic significance of a D-dimer cut-off level of >3 μg/ml in colorectal cancer patients treated with standard chemotherapy plus bevacizumab. Jpn J Clin Oncol (2010) 40: 933-937.| Reitsma PH and Rosendaal FR: Activation of innate immunity in patients with venous thrombosis: the Leiden Thrombophilia Study. J Thromb Haemost (2004) 2: 619-622.| van Aken BE, Reitsma PH and Rosendaal FR: Interleukin 8 and venous thrombosis: evidence for a role of inflammation in thrombosis. Br J Haematol (2002) 116: 173-177.| Ay C, Dunkler D, Marosi C, Chiriac AL, Vormittag R, Simanek R, Quehenberger P, Zielinski C and Pabinger I: Prediction of venous thromboembolism in cancer patients. Blood (2010) 116: 5377-5382.| Mulder FI, Candeloro M, Kamphuisen PW, Di Nisio M, Bossuyt PM, Guman N, Smit K, Büller HR and van Es N; CAT-prediction collaborators: The Khorana score for prediction of venous thromboembolism in cancer patients: A systematic review and metaanalysis. Haematologica (2019) 104: 1277-1287.| van Es N, Franke VF, Middeldorp S, Wilmink JW and Büller HR: The Khorana score for the prediction of venous thromboembolism in patients with pancreatic cancer. Thromb Res (2017) 150: 30- 32.| |
| JaLCDOI | 10.18926/AMO/63405 |
|---|---|
| FullText URL | 76_2_121.pdf |
| Author | Okazaki, Yuki| Furumatsu, Takayuki| Hiranaka, Takaaki| Kamatsuki, Yusuke| Nakata, Eiji| Tetsunaga, Tomonori| Yamane, Kentaro| Ozaki, Toshifumi| |
| Abstract | Bone marrow edema (BME) after meniscus injury and risk factors for subchondral insufficiency fracture of the knee (SIFK) have been reported. However, their association with medial meniscus posterior root tear (MMPRT) remains unknown. We investigated the association of BME volume (BME-V), posterior shinycorner lesion (PSCL), and SIFK with MMPRT to examine the correlations between BME-V and medial meniscus extrusion (MME), PSCL and duration from injury to the time of magnetic resonance imaging (duration), and SIFK and duration. Twenty-nine patients who underwent surgery for MMPRT were included (mean age, 59.2; range, 39-84). The presence of PSCL, femoral BME-V (cm3), and SIFK grade (1-4) were evaluated. Preoperative factors, such as MME (mm) and duration (weeks), were investigated using multivariate linear/ logistic regression analyses. Multivariate linear regression analysis revealed duration as a significant factor for high-grade SIFK (p<0.01). Multivariate logistic regression analysis revealed duration as a significant factor for the presence of PSCL (odds ratio=0.94, p<0.05). A long duration of MMPRT leads to severe MME and highgrade SIFK (3 and 4), often resulting in knee arthroplasty. Early diagnosis of MMPRT and pullout repair can prevent severe MME and high-grade SIFK. |
| Keywords | medial meniscus posterior root tear subchondral insufficiency fracture bone marrow edema meniscus extrusion |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 121 |
| End Page | 127 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503439 |
| Web of Science KeyUT | 000792374900003 |
| JaLCDOI | 10.18926/AMO/63404 |
|---|---|
| FullText URL | 76_2_113.pdf |
| Author | Namio, Keiichi| Miyatake, Nobuyuki| Hishii, Shuhei| Kondo, Takashi| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Suzuki, Hiromi| Hashimoto, Hiroo| |
| Abstract | This study aimed to investigate the link between prolonged sedentary bouts and health-related quality of life (QOL) in patients on chronic hemodialysis (CHD). A total of 84 outpatients on CHD, aged 71.6±11.8 years, were enrolled in this cross-sectional study. Parameters for prolonged sedentary bouts [i.e., ≧ 30 min (% and bout) and ≧ 60 min (% and bout)] were measured using a triaxial accelerometer. Health-related QOL (HRQOL) was evaluated by the Euro-QOL (EQ-5D). Clinical parameters were obtained from medical records. Relatively prolonged sedentary bouts (%) were 44.0±18.2 (≧ 30 min) and 29.8±16.5 (≧ 60 min) for total days. Prolonged sedentary bouts (bouts) were 6.2±2.7 (≧ 30 min) and 2.7±1.6 (≧ 60 min) for total days. EQ-5D scores were 0.728±0.220. All prolonged sedentary bout parameters were negatively correlated with EQ-5D scores, except for prolonged sedentary bouts (≧ 60 min) (min) and relatively prolonged sedentary bouts (%) on hemodialysis days. Multiple regression analysis showed that prolonged sedentary bout parameters were an important factor in EQ-5D scores even after adjusting for confounding factors for total and non-hemodialysis days. Our results suggested that prolonged sedentary bouts were closely associated with HRQOL in patients on CHD, especially on non-hemodialysis days. |
| Keywords | prolonged sedentary bouts hemodialysis EQ-5D QOL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 113 |
| End Page | 119 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503438 |
| Web of Science KeyUT | 000792374900002 |
| JaLCDOI | 10.18926/AMO/63403 |
|---|---|
| FullText URL | 76_2_105.pdf |
| Author | Takaoka, Megumi| Ohsumi, Shozo| Ikejiri, Haruka| Shidahara, Tomohiro| Miyoshi, Yuichiro| Takahashi, Mina| Takashima, Seiki| Aogi, Kenjiro| |
| Abstract | Cases of breast cancer metastasis after achieving a pathological complete response (pCR) with neoadjuvant chemotherapy (NAC) are sometimes encountered in clinical practice. We investigated the prognostic factors for pCR in patients with breast cancer after NAC. This retrospective cohort study included patients with localized breast cancer who underwent NAC followed by surgery between 2004 and 2020 and achieved a pCR. The associations between clinical factors and distant metastasis-free survival rate were statistically analyzed. We analyzed data for 127 patients. Twelve patients (9.4%) had distant metastases, and seven (5.5%) died. For estrogen receptor (ER)-positive patients, the distant metastasis-free survival rate was 94.6% for both 5 and 8 years. In contrast, ER-negative patients had a distant metastasis-free survival rate of 87.6% and 85.4% for 5 and 8 years (p=0.094), respectively. In cT0-2 patients, the distant metastasis-free survival rate was 92.4% for 5 years and 90.5% for 8 years, whereas in cT3-4 patients, the distant metastasis-free survival rate was 83.5% for 5 years and 83.5% for 8 years (p=0.301). This study suggested that patients with ER-negative, pre-NAC cT3 or T4 breast cancer who had achieved a pCR after NAC tended to have a worse prognosis. |
| Keywords | breast carcinoma neoadjuvant therapy prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 105 |
| End Page | 111 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503437 |
| Web of Science KeyUT | 000792374900001 |
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J Clin Oncol (2012) 30: 1796- 1804.| Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W and Minckwitz Gv: Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet (2014) 384: 164-172.| Mougalian SS, Hernandez M, Lei X, Lynch S, Kuerer HM, Symmans WF, Theriault RL, Fornage BD, Hsu L, Buchholz TA, Sahin AA, Hunt KK, Yang WT, Hortobagyi GN and Valero V: Ten-Year Outcomes of Patients With Breast Cancer With Cytologically Confirmed Axillary Lymph Node Metastases and Pathologic Complete Response After Primary Systemic Chemotherapy. JAMA Oncol (2016) 2: 508-516.| Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y and Toi M: Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy. N Eng J Med (2017) 376: 2147-2159.| von Minckwitz G, Huang CS, Mano MS, Loibl S, Mamounas EP, Untch M, Wolmark N, Rastogi P, Schneeweiss A, Redondo A, Fischer HH, Jacot W, Conlin AK, Arce-Salinas C, Wapnir IL, Jackisch C, DiGiovanna MP, Fasching PA, Crown JP, Wulfing P, Shao Z, Caremoli ER, Wu H, Lam LH, Tesarowski D, Smitt M, Douthwaite H, Singel SM and Geyer CE Jr: Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer. N Eng J Med (2019) 380: 617-628.| Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet (2014) 384: 164-172.| I-SPY2 Trial Consortium. Association of Event-Free and Distant Recurrence‒Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial. JAMA Oncol (2020) 6: 1355-1362.| Resende U, Cabello C, Ramalho SOB and Zeferino LC: Prognostic assessment of breast carcinoma submitted to neoadjuvant chemotherapy with pathological non-complete response. BMC Cancer (2019) 19: 601.| Chou HH, Kuo WL, Yu CC, Tsai HP, Shen SC, Chu CH, Yu MC, Lo YF, Dabora MA, Chang HK, Lin YC, Ueng SH and Chene SC: Impact of age on pathological complete response and locoregional recurrence in locally advanced breast cancer after neoadjuvant chemotherapy. Biomed J (2019) 42: 66-74.| Kennecke H, Yerushalmi R, Woods R, Cheang MCU, Voduc D, Speers CH, Nielsen TO and Karen Gelmon: Metastatic Behavior of Breast Cancer Subtypes. J Clin Oncol (2010) 28: 3271-3277.| Wang R, Zhu Y, Liu X, Liao X, He J and Niu L: The Clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancer. BMC Cancer (2019) 19: 1091.| Martin M, Holmes FA, Ejlertsen B, Delaloge S, Moy B, Iwata H, von Minckwitz G, Chia SKL, Mansi J, Barrios CH, Gnant M, Tomašević Z, Denduluri N, Šeparović R, Gokmen E, Bashford A, Borrego MR, Kim SB, Jakobsen EH, Ciceniene A, Inoue K, Overkamp F, Heijns JB, Armstrong AC, Link JS, Joy AA, Bryce R, Wong A, Moran S, Yao B, Xu F, Auerbach A, Buyse M and Chan A: Neratinib after trastuzumab-based adjuvant therapy in HER2- positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol (2017) 18: 1688-1700.| Murthy RK, Loi S, Okines A, Paplomata E, Hamilton E, Hurvitz SA, Lin NU, Borges V, Abramson V, Anders C, Bedard PL, Oliveira M, Jakobsen E, Bachelot T, Shachar SS, Muller V, Braga S, Duhoux FP, Greil R, Cameron D, Carey LA, Curigliano G, Gelmon K, Hortobagyi G, Krop I, Loibl S, Pegram M, Slamon D, Palanca-Wessels MC, Walker L, Feng W and Winer EP: Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer. N Engl J Med (2020) 382: 597-609.| McGuire SE, Gonzalez-Angulo AM, Huang EH, Tucker SL, Kau SWC, Yu TK, Strom EA, Oh JL, Woodward WA, Tereffe W, Hunt KK, Kuerer HM, Sahin AA, Hortobagyi GN and Buchholz TA: Postmastectomy radiation improves the outcome of patients with locally advanced breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys (2007) 68: 1004-1009.| |
