| ID | 55208 |
| JaLCDOI | |
| FullText URL | |
| Author |
Washio, Kana
Department of Pediatrics, Okayama University Hospital
Muraoka, Michiko
Department of Pediatrics, National Hospital Organization Fukuyama Medical Center
Kanamitsu, Kiichiro
Department of Pediatrics, Okayama University Hospital
Oda, Megumi
Department of Pediatrics, Okayama University Hospital
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| Abstract | We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.
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| Keywords | langerhans cell histiocytosis (LCH)
hemophagocytic lymphohistiocytosis (HLH)
hematopoietic stem cell transplantation (HSCT)
reduced-intensity conditioning (RIC)
refractory
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| Amo Type | Case Report
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2017-06
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| Volume | volume71
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| Issue | issue3
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| Publisher | Okayama University Medical School
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| Start Page | 249
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| End Page | 254
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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| PubMed ID |
