ID | 32306 |
JaLCDOI | |
FullText URL | |
Author |
Hashimoto, Yasuhiko
Gomita, Yutaka
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Abstract | The influences of emotional changes induced by being exposed to a new environment on the pharmacokinetics of plasma drug concentration were studied in male Wistar rats. Transfer from a familiar home cage to a new home cage was considered to induce psychological (non-physical) emotional changes. First, nicorandil and zonisamide, drugs that act on the peripheral system and central nervous systems, were used, respectively. Immediately after oral administration of nicorandil (10 mg/kg) or zonisamide (50 mg/kg), the animals were transferred to new home cages. Plasma nicorandil and zonisamide concentrations were determined by high-performance liquid chromatography at 1 and 4 h after administration. Plasma nicorandil concentration in the group transferred to new home cages was significantly decreased relative to levels in the non-transferred control group. However, zonisamide concentrations were unchanged. These findings suggest that the pharmacokinetics of nicorandil, but not those of zonisamide, tend to be influenced by non-physically induced emotional changes. |
Keywords | psychologically induced emotional changes
drug plasma concentration
nicorandil
zonisamide
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2000-02
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Volume | volume54
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 45
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End Page | 48
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |