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ID 31316
JaLCDOI
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Author
Marukawa, Masaomi
Hiyama, Jyunichiro
Shiota, Yutaro
Ono, Tetsuya
Sasaki, Naomi
Taniyama, Kiyomi
Mashiba, Hiroto
Abstract

Five patients with malignant pleural mesothelioma (MPM) were studied to determine whether CYFRA 21-1 is useful for diagnosis of this disease. In pleural effusions, the median concentration of CYFRA 21-1 from 4 patients with MPM was significantly higher than for 34 patients with benign diseases. The sensitivity of serum CYFRA 21-1 for diagnosis of MPM was 40% and its concentration changed in proportion to disease activity in all cases. Immunohistochemically, anticytokeratin 19 antibody revealed strong staining in both epithelial and sarcomatous MPM tissues. Based on these results, we conclude that measurement of CYFRA 21-1 in pleural effusions and serum may be useful for diagnosing and monitoring MPM.

Keywords
malignant pleural mesothelioma
tumor marker
CYFRA21-1
Amo Type
Article
Published Date
1998-04
Publication Title
Acta Medica Okayama
Volume
volume52
Issue
issue2
Publisher
Okayama University Medical School
Start Page
119
End Page
123
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT