ID | 30399 |
JaLCDOI | |
FullText URL | |
Author |
Tanaka, Noriaki
Okamoto, Yasuhisa
Gotoh, Kiyotoshi
Hizuta, Akio
Yunoki, Shigeru
Orita, Kunzo
|
Abstract | The antitumor effects of indomethacin and interleukin 2 (IL-2) were studied in C3H/HeJ mice inoculated with MH134 hepatoma cells. Combined treatment with indomethacin and IL-2 augmented natural killer (NK) cells in mice with MH134-induced peritoneal carcinomatosis, and the survival of the treated mice was significantly longer than the non-treated mice. In animals with subcutaneous MH134 tumors, the combined therapy with indomethacin and IL-2 significantly suppressed tumor growth and induced complete regression of the tumor in three out of five mice. These results suggest that indomethacin and IL-2 therapy could be effective on human gastrointestinal cancer cells as well. |
Keywords | indomethacin
interleukin-2
mouse
hepatoma
|
Amo Type | Article
|
Publication Title |
Acta Medica Okayama
|
Published Date | 1995-10
|
Volume | volume49
|
Issue | issue5
|
Publisher | Okayama University Medical School
|
Start Page | 241
|
End Page | 245
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ISSN | 0386-300X
|
NCID | AA00508441
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Content Type |
Journal Article
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language |
English
|
File Version | publisher
|
Refereed |
True
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PubMed ID | |
Web of Science KeyUT |