ID | 30397 |
JaLCDOI | |
FullText URL | |
Author |
Ahaneku, Joseph Eberendu
Agbedana, Olu Emmanuel
Taylor, Oladunni Grace
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Abstract | Eighty-one adult Nigerians with essential hypertension were randomly allocated to receive doxazosin, hydrochlorothiazide/amloride, or amlodipine. In each group, the patients were further classified as obese and non-obese, and total cholesterol as well as high density lipoprotein (HDL) cholesterol was determined before and after the 3-month treatment period. The total cholesterol level was significantly reduced in the non-obese patients, but did not show any significant change in the obese patients after doxazosin therapy, indicating the beneficial effects of doxazosin therapy in non-obese patients. The levels of total cholesterol increased and HDL cholesterol decreased in both the obese and the non-obese patients after hydrochlorothiazide/amloride therapy. Amlodipine treatment did not cause any significant change in the total and HDL cholesterol levels in both the obese and non-obese patients. These findings are worthy of consideration by clinicians and researchers when selecting the most appropriate drug for antihypertensive pharmacotherapy. |
Keywords | body mass index
cholesterol
hypertension
African patients
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1995-10
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Volume | volume49
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Issue | issue5
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Publisher | Okayama University Medical School
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Start Page | 267
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End Page | 270
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |