Elevated IgA antibodies to Epstein-Barr virus in children with chronic active Epstein-Barr virus infection.

Wakiguchi, Hiroshi; Fujieda, Mikiya; Kubota, Haruo; Matsumoto, Kenji; Wakiguchi, Akiko; Kurashige, Takanobu; Oda, Megumi

ID	30885
JaLCDOI	10.18926/AMO/30885
FullText URL	fulltext.pdf 383 KB
Author	Wakiguchi, Hiroshi Fujieda, Mikiya Kubota, Haruo Matsumoto, Kenji Wakiguchi, Akiko Kurashige, Takanobu Oda, Megumi Kaken ID publons researchmap
Abstract	Anti-Epstein-Barr virus (EBV) antibodies were tested in 11 children with chronic active EBV infection. Anti-virus capsid antigen (VCA)-IgG antibody titers ranged from 1:640 to 1:10,240. Anti-VCA-IgM antibody was consistently positive in 5 of the 11 patients; anti-VCA-IgA antibody was consistently positive in 6 of the 10 patients; anti-early antigen (EA)-IgG antibody was consistently positive in 10 of the 11 patients and anti-EA-IgA antibody was consistently positive in 4 out of the 7 patients. Anti-EBV nuclear antigen (EBNA) antibody was not detected in two patients. Consistently positive anti-VCA-IgA- and anti-EA-IgA- antibody may be a characteristic feature of abnormal antibody responses in severe chronic active EBV-infection in childhood.
Keywords	IgA antibody Epstein-Barr virus chronic active EBV-infection
Amo Type	Article
Publication Title	Acta Medica Okayama
Published Date	1989-06
Volume	volume43
Issue	issue3
Publisher	Okayama University Medical School
Start Page	193
End Page	196
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
File Version	publisher
Refereed	True
PubMed ID	2548373
Web of Science KeyUT	A1989AG01600008