ID | 31928 |
JaLCDOI | |
FullText URL | |
Author |
Sakagami, Kenichi
Miyazaki, Masashi
Matsuoka, Junji
Shiozaki, Shigehiro
Orita, Kunzo
|
Abstract | An artificial liver support system for plasma exchange and plasma perfusion through BR-601 resin using a membrane separator was applied to 5 patients with postoperative liver failure. Percent absorption of total and direct bilirubin, and of bile acids were 77.1 +/- 6.4, 78.4 +/- 6.1, and 93.4 +/- 3.6%, respectively, when 250 ml of plasma was treated. Percent reductions in total and direct bilirubin, and in bile acids were 24.5 +/- 5.8, 25.5 +/- 5.8 and 30.9 +/- 8.5%, respectively. In contrast, percent reductions in total and direct bilirubin, and in bile acids by plasma exchange were 30.9 +/- 13.3, 34.5 +/- 12.5 and 24.2 +/- 8.5%, respectively. The coma grade was improved in 4 out of 5 cases, but unfortunately the patients did not recover. In conclusion, plasma perfusion through BR-601 resin is expected to play a promising role in artificial liver support systems because of its capacity to absorb bilirubin and bile acids. |
Keywords | anion exchange resin (BR-601)
postoperative liver failure
artificial liver support
|
Amo Type | Article
|
Publication Title |
Acta Medica Okayama
|
Published Date | 1986-10
|
Volume | volume40
|
Issue | issue5
|
Publisher | Okayama University Medical School
|
Start Page | 249
|
End Page | 255
|
ISSN | 0386-300X
|
NCID | AA00508441
|
Content Type |
Journal Article
|
language |
English
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
Web of Science KeyUT |