ID | 31926 |
JaLCDOI | |
FullText URL | |
Author |
Hattori, Yukio
Moriwaki, Akiyoshi
Hayashi, Yasushi
Hori, Yasuo
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Abstract | Accumulation of cyclic AMP elicited by glutamate was examined in slices from different cortical areas of rats 30 to 60 days after ferrous chloride solution was injected into the left sensorimotor cortex to induce an epileptic focus. In the anterior cortex of rats showing dominant electrographic spike activity on either side of the cortex, the glutamate-elicited accumulation of cyclic AMP was greater on the dominant side than on the other. In the anterior cortex of rats showing nearly equal spike activity on either side, the accumulation was greater on the side ipsilateral to the injection site than on the other. Different inhibitory effects of 3-isobutyl-1-methylxanthine on the elicitation of cyclic AMP accumulation by glutamate was observed in relation to the patterns of spike activity. |
Keywords | cyclic AMP
glutamate
3-isobuty-1-methylxanthine
rat cerebral cortex
ironinduced epilepsy
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1986-10
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Volume | volume40
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Issue | issue5
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Publisher | Okayama University Medical School
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Start Page | 277
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End Page | 280
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |