ID | 30347 |
JaLCDOI | |
FullText URL | |
Author |
Watanabe, Akiharu
Nakatsukasa, Harushige
Kobayashi, Michio
Nagashima, Hideo
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Abstract | Carbon tetrachloride (CCl4)-induced hepatotoxicity was potentiated by pretreatment with beta-phenethyl alcohol, abundantly present in sake. The injury was determined by serum GPT levels and histological examination. Similar results were observed in ethanol- and phenobarbital-pretreated rats. Acetaminophen-induced hepatotoxicity was not accentuated by beta-phenethyl alcohol or ethanol pretreatment. The activities of liver microsomal enzymes, such as cytochrome P-450, cytochrome b5 reductase, aniline hydroxylase and aminopyrine demethylase, were not altered in beta-phenethyl alcohol-pretreated rats. Thus, CCl4-induced hepatotoxicity potentiation by beta-phenethyl alcohol administration is postulated to be due to a mechanism other than increased free radical generation. |
Keywords | ?-phenethyl alcohol
ethanol
phenobarbital
carbon tetrachloride
acetaminophen
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1984-10
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Volume | volume38
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Issue | issue5
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Publisher | Okayama University Medical School
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Start Page | 453
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End Page | 459
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |