ID | 32549 |
JaLCDOI | |
FullText URL | |
Author |
Hatase, O.
Yamamoto, G.
Oda, T.
|
Abstract | Effect of ATP and substrates on 2,4-dinitrophenol-induced adenosine triphcsphatase (E. C. 3.6. 1. 4.) activity and respiration of isolated rat liver mitochondria has been investigated. 1. The oxidation of sodium succinate inhibited the action of 2, 4-DNP on the induction of adenosine triphosphatase activity in the mitochondria. 2. A moderately large amount of sodium succinate restored the suppressed mitochondrial respiration due to 2, 4-DNP. 3. Adenosine-5'-triphosphate (ATP) restored quantitatively the released and inhibited mitochondrial respiration due to 2,4-DNP, and its prior addition prevented also quantitatively the action of 2,4-DNP on the mitochondrial oxygen up-take. These ATP effects were oligomycin sensitive, and they were considered to manifest their actions through the phosphorylation system. |
Amo Type | Article
|
Publication Title |
Acta Medicinae Okayama
|
Published Date | 1969-06
|
Volume | volume23
|
Issue | issue3
|
Publisher | Okayama University Medical School
|
Start Page | 227
|
End Page | 235
|
NCID | AA00041342
|
Content Type |
Journal Article
|
language |
English
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
NAID |