ID | 32579 |
JaLCDOI | |
FullText URL | |
Author |
Shigehisa, Morio
|
Abstract | For the purpose to see how the suppression of the nucleic acid synthesis disturbs the cell specialization process the author observed the erythroid cell specialization in anemic rats by treating them with aminopterin (AP) and 5-bromouracil (BU). The observations indicate that the AP injection inhibits the mitosis of erythroblast with the acceleration of hemoglobin synthesis and the denucleation. The bromouracil administration scarcely suppressed the mitosis and the appearance of acidophilicity of erythroblast was retarded. Data indicate that the inhibition of mitosis accelerates the specialization or somatic protein synthesis of erythroblast. The acting mechanisms of the medicaments were discussed from the characteristics of these agents as the analogue of the substances related to DNA metabolism. |
Amo Type | Article
|
Publication Title |
Acta Medicinae Okayama
|
Published Date | 1968-10
|
Volume | volume22
|
Issue | issue5
|
Publisher | Okayama University Medical School
|
Start Page | 251
|
End Page | 262
|
NCID | AA00041342
|
Content Type |
Journal Article
|
language |
English
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
NAID |