JaLCDOI 10.18926/AMO/32468
FullText URL fulltext.pdf
Author Kono, Hiroshi|
Abstract

Sowohl aus dem Grunde, den Mechanismus des gestörten BTS-Stoffwechsels bei den Leberkrankheiten zu erkennen, als auch Beobachtungen für seine Behandlungen zu machen, wurden die Ein£liisse von Zucker, Thiamin und seinen Derivaten (BTMP, TTFD), Thioctsäure, der Verbindung zwischen dem Derivat von Thiamin und Thioctsaure (TATD), Kalium- und Magnesium-Asparaginat und Glucocorticoiden auf den BTS-Blutspiegel untersucht. Das führte zu folgenden Ergebnissen : 1) Der Anstieg des BTS-Blutspiegcls nach Belastung von Glukose bzw. Sorbit wurde beide Male beobachtet, aber er war nach Sorbit geringer als nach Glukose. Das bedeutet, dass Sorbit die BTS-Oxydation fördert. 2) Während der Anstieg des BTS-Blutspiegels mit Thiamin hydrochlorid nicht gehemmt wurde, wurde er mit Thioctsäure in vielen Fällen gehemmt, insbesondere in Rekonvaleszenz der akuten Hepatitis. 3) Nach der Verabreichung Von BTMP, TTFD und TATD war der BTS-Blutspiegel herabgesetzt, aber ihre Einwirkung war bei den Fällen mit gestörter Leberhämodynamik nicht gut. 4) Ebenso hat Kalium- und Magnesium-Asparaginat ungeFähr im Drittel der Fälle den BTS-Blutspiegel erniedrigt. Aber seine Einwirkung in Fällen mit gestörter Leberhämodynamik war ungünstig. 5) Der BTS-Blutspiegel wurde durch Glucocorticoide erhöht.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1964-04
Volume volume18
Issue issue2
Publisher Okayama University Medical School
Start Page 93
End Page 110
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
NAID 120002312074
JaLCDOI 10.18926/AMO/32467
FullText URL fulltext.pdf
Author Ofuji, Tadashi|
Abstract

1) OX substance showed marked cytotoxicities in cell suspension culture of Yoshida sarcoma cells, celothelioma cells, and Ehrlich ascites tumor cells. It has become clear that the cytotoxicities have two aspects; one, nuclear shrinkage and karyolisis as seen with Carzinophilin and the other, cytoplasmic swelling as seen with Nitromin. 2) OX substance was effective by its contact action on patients with peritonitis carcinomatosa, celothelioma and rectal carcinoma. 3) Esterified OX substance was injected intravenously or intraperitonealy into CBA mice with ascites leukemia. The substance prolonged their life span and inhibited the progression of leukemia. As it was possible to give the substance repeatedly into mouse tail veins in this experiment, in the future, OX substance might become intravenously injectable for the treatment of patients with leukemia and solid malignant tumors.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1964-04
Volume volume18
Issue issue2
Publisher Okayama University Medical School
Start Page 55
End Page 64
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 14206730
NAID 120002311400
JaLCDOI 10.18926/AMO/32466
FullText URL fulltext.pdf
Author Hiraki, Kiyoshi| Kimura, Ikuro|
Abstract

Eleven cases of malignant lymphomas were treated with a fibroblast-inhibiting agent, chloroquine, and of these, one case of lymphosarcoma, two of acute and chronic lymphocytic leukemia, respectively, and two of giant follicle lymphoma showed regression of the enlarged lymph nodes and also of the enlarged spleen in some of the splenomegalic patients. In contrast, the drug proved ineffective in two cases of reticulum cell sarcoma and Hodgkin's disease, respectively. The side effects of the drug were minimal, and three of the 11 cases complained of nausea, anorexia or palpebral ptosis, which disappeared by decreasing the drug dosage or combining ATP preparation. The tissue culture study of biopsied lymph nodes from lymphocytic leukemia showed inhibition of the growth zone in a medium containing chloroquine indicating a possibility of the drug action not only upon the stromal tissue but also upon the parenchymal tumor cell.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1964-04
Volume volume18
Issue issue2
Publisher Okayama University Medical School
Start Page 87
End Page 92
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 14204462
NAID 120002311940
JaLCDOI 10.18926/AMO/32465
FullText URL fulltext.pdf
Author Hiraki, Kiyoshi| Kimura, Ikuro|
Abstract

A fibroblast-inhibiting agent, chloroquine, used in the treatment of animal tumors led to a reasonably good result, and this approach was extended to the treatment of human cancers. Of histologically proven 54 cases, the drug was effective in 38, ineffective in 15, and unknown in one. It proved to be effective in all the patients who were treated for over 2 months with exception of terminal patients. Of the various malignant tumors treated, excellent therapeutic effects were obtained in patients with carcinoma of the lung and bladder. In the cases where the drug was effective there were a decrease of the size of tumors, fall of serum lactic dehydrogenase, increase of necrosis, inhibition of the stroma, as well as improvement of the symptoms and general condition. As to the mechanisms of the drug action, it would be necessary to consider of its anti-inflammatory and humoral effects upon the host in addition to its inhibitory action on the stromal connective tissue of cancers. The present chloroquine treatment appears to have its indication in inoperable cases, and pre- and post-operative cases, and for the prevention of reccurrence of tumors. Studies are currently in progress in our laboratory to discover more potent fibroblastinhibiting agents and on the combined chemotherapy of chloroquine and other anti-turnor agents. We are indebted to the Department of Urology of our University for the generosity to allow us to use the clinical data on patients with cancer of the urinary bladder.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1964-04
Volume volume18
Issue issue2
Publisher Okayama University Medical School
Start Page 71
End Page 86
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 14204461
NAID 120002311710
JaLCDOI 10.18926/AMO/32464
FullText URL fulltext.pdf
Author Ubuka, Toshihiko| Horiuchi, Katsumi| Shimomura, Takehira| Mizuhara, Shunzi|
Abstract

In the course of experimental isovalthinuria induced by cholic acid, S35-methionine or S35-cystine administered was incorporated into urinary isovalthine in guinea pigs. Sulfur atom of cysteine seems to be utilized much better for isovalthine synthesis than that of methionine.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1964-04
Volume volume18
Issue issue2
Publisher Okayama University Medical School
Start Page 65
End Page 70
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 14204460
NAID 120002311634