ID | 65742 |
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Author |
Chen, Mengxi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tanaka, Takehiro
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Igawa, Takuro
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Han, Yanyan
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Peng, Fangli
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Jin, Zaishun
Department of Pathology, Mudanjiang Medical University
Yoshino, Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | An ectopic pancreas is defined as pancreatic tissue outside its normal location, anatomically separated from the pancreas.
The transcription factor pancreas/duodenum homeobox protein 1 (PDX1) is involved in maintaining the pancreas and functions in early pancreatic development, beta cell differentiation, and endocrine non beta cells. Pancreatic transcription factor 1 subunit alpha (PTF1A) affects exocrine cell formation and regulation of acinar cell identity, and is expressed in exocrine cells as a transcription factor. The depletion of SALL4 disrupts self-renewal and induces differentiation. To clarify which of PDX1, PTF1A, or SALL4 determines the difference in Heinrich's classification, we examined the localization and number of positive cells. We analyzed the differential expression of PDX1, PTF1A, and SALL4 in large and small ducts in ectopic pancreas by immunohistochemistry. Results showed that the number of PTF1A-positive cells in large ducts was more widespread in type I than in type II in the gastro-duodenum, and more SALL4-positive cells were noticed in large ducts than in small ducts in the gastro-duodenum of type II. Our results revealed that PTF1A might promote exocrine differentiation in developing the pancreatic tissues, and that those with widespread expression differentiate into exocrine cells. |
Keywords | PDX1
PTF1A
SALL4
Ectopic pancreas
Gastro-duodenum
Jejunum
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Published Date | 2023-07
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Publication Title |
Heliyon
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Volume | volume9
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Issue | issue7
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Publisher | Cell Press
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Start Page | e18241
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ISSN | 2405-8440
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2023 The Authors.
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.1016/j.heliyon.2023.e18241
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License | http://creativecommons.org/licenses/by-nc-nd/4.0/
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