ID | 57804 |
FullText URL | |
Author |
Yumoto, Yasuhiro
Radioisotope Centre, Okayama University
Yagi, Takahito
Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Sato, Shuhei
Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nouso, Kazuhiro
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kobayashi, Yoshiyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ohmoto, Masaki
Department of Saiseikai Imabari Hospital
Yumoto, Eiichiro
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nagaya, Isao
Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nakatsukasa, Harushige
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
|
Abstract | BACKGROUND:
Assessment of hepatic functional reserve is important in hepatic resection. The aim of this study was to evaluate the role of hepatic asialoglycoprotein receptor (ASGP-R) analysis in the preoperative estimation of remnant liver function in liver surgery. METHODS: One hundred and one patients undergoing hepatic resection for liver tumours were studied. Seventeen patients had preoperative percutaneous transhepatic portal vein embolization (PTPE). Function of the hepatic remnant was estimated before surgery using radioactivity in fusion images of both liver single-photon emission computed tomography and computed tomography scans using (99m)Tc-labelled diethylene triamine penta-acetate-galactosyl-human serum albumin. RESULTS: All three patients with an ASGP-R concentration below 400 nmol/l and preoperative total amount of receptor in the future remnant liver (R0-remnant) of less than 53.0 nmol per liver died. Two patients with chronic hepatitis and R0-remnant values between 53.0 and 65.0 nmol per liver and a receptor concentration lower than 600 nmol/l developed liver dysfunction. The incidence of liver failure decreased inversely with increasing R0-remnant value. CONCLUSION: A combination of receptor concentration and the amount of hepatic receptor in the future liver remnant as detected on fusion images is useful in evaluating the risk of postoperative liver failure. |
Keywords | hepatocellular carcinoma
hepatic resection
remnant hepatic function
fusion image of SPECT and X-ray CT
|
Note | "This is the peer reviewed version of the following article: Preoperative estimation of remnant hepatic function using fusion images obtained by Tc-99m-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography, which has been published in final form at https://doi.org/10.1002/bjs.7025. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
|
Published Date | 2010-04-22
|
Publication Title |
British Journal of Surgery
|
Volume | volume97
|
Issue | issue6
|
Publisher | Wiley
|
Start Page | 934
|
End Page | 944
|
ISSN | 0007-1323
|
NCID | AA00575132
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
File Version | author
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.1002/bjs.7025
|