| ID | 32999 |
| FullText URL | |
| Author |
Adachi, R.
Takaya, T.
Kuriyama, K.
Higashibata, A.
Ishioka, N.
Kagawa, H.
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| Abstract | We have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans. Both mutant and wild-type strains were subjected to 10 days of microgravity during spaceflight and compared to ground control groups. No significant change in muscle fiber size or quantity of the protein was observed in wild-type worms; where as atrophy of body-wall muscle and an increase in thick filament proteins were observed in the paramyosin mutant unc-15(e73) animals after spaceflight. We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function.
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| Keywords | Spaceflight
Microgravity
Myosin heavy chain
Paramyosin
C. elegans
Mutation
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| Note | Published with permission from the copyright holder.
This is a author's copy,as published in Advances in Space Research , 2008, volume 41, issue 5, pp816-823. Publisher URL: http://dx.doi.org/10.1016/j.asr.2007.10.016 Copyright © 2007 COSPAR. Published by Elsevier Ltd. All rights reserved. |
| Published Date | 2008
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| Publication Title |
Advances in Space Research
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| Volume | volume41
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| Issue | issue5
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| Publisher | Elsevier Ltd.
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| Start Page | 816
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| End Page | 823
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| ISSN | 0273-1177
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| NCID | AA10636539
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | © 2007 COSPAR Published by Elsevier Ltd.
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| File Version | author
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| Refereed |
True
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| DOI | |
| Web of Science KeyUT | |
| Submission Path | biology_general/38
|
