ID | 11836 |
Eprint ID | 11836
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FullText URL | |
Title Alternative | 口腔癌における染色体2q21-37部位の微調欠失マッピング
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Author |
Cengiz, Beyhan
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Abstract | We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.
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Keywords | Oral cancer
2q
2q21-24
2q33-35
2q37.3
Loss of heterozygosity
ING5
CASP8
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Note | http://dx.doi.org/10.1016/j.oraloncology.2006.03.004
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Published Date | 2007-03-23
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Publication Title | |
Content Type |
Thesis or Dissertation
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Grant Number | 甲第3341号
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Granted Date | 2007-03-23
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Thesis Type |
Doctor of Philosophy
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Grantor | 岡山大学
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Official Url | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16857411&dopt=Abstract
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language |
Japanese
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File Version | none
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Refereed |
Unknown
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